Spectral domain-optical coherence tomography to detect localized retinal nerve fiber layer defects in glaucomatous eyes.

This study examines the ability of RTVue, Cirrus and Spectralis OCT Spectral domain-optical coherence tomographs (SD-OCT) to detect localized retinal nerve fiber layer defects in glaucomatous eyes. In this observational case series, four glaucoma patients (8 eyes) were selected from the University of California, San Diego Shiley Eye Center and the Diagnostic Innovations in Glaucoma Study (DIGS) based on the presence of documented localized RNFL defects in at least one eye confirmed by masked stereophotograph assessment. One RTVue 3D Disc scan, one RTVue NHM4 scan, one Cirrus Optic Disk Cube 200x200 scan and one Spectralis scan centered on the optic disc (15x15 scan angle, 768 A-scans x 73 B-scans) were obtained on all undilated eyes within a single session. Results were compared with those obtained from stereophotographs. In 6 eyes the presence of localized RNFL defects was detected by stereophotography. In general, by qualitatively evaluating the retinal thickness maps generated, all SD-OCT instruments examined were able to confirm the presence of localized glaucomatous structural damage seen on stereophotographs. This study confirms SD-OCT is a promising technology for glaucoma detection as it may assist clinicians identify the presence of localized glaucomatous structural damage.

[1]  J. Katz,et al.  Sensitivity and specificity of the StratusOCT for perimetric glaucoma. , 2005, Ophthalmology.

[2]  Sebastian Wolf,et al.  Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination. , 2008, Investigative ophthalmology & visual science.

[3]  Anthony J Correnti,et al.  Optical coherence tomography measurement of macular and nerve fiber layer thickness in normal and glaucomatous human eyes. , 2003, Ophthalmology.

[4]  Aziz A. Khanifar,et al.  Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration. , 2008, Ophthalmology.

[5]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[6]  J G Fujimoto,et al.  Evaluation of focal defects of the nerve fiber layer using optical coherence tomography. , 1996, Ophthalmology.

[7]  B. Bouma,et al.  Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. , 2003, Optics letters.

[8]  A. Fercher,et al.  Performance of fourier domain vs. time domain optical coherence tomography. , 2003, Optics express.

[9]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[10]  J. Crowston,et al.  Validation of a predictive model to estimate the risk of conversion from ocular hypertension to glaucoma. , 2005, Archives of ophthalmology.

[11]  J M Seddon,et al.  Spectral domain optical coherence tomography for quantitative evaluation of drusen and associated structural changes in non-neovascular age-related macular degeneration , 2008, British Journal of Ophthalmology.

[12]  U. Schmidt-Erfurth,et al.  Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases. , 2005, Investigative ophthalmology & visual science.

[13]  G. Wollstein,et al.  Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography. , 2008, Ophthalmology.

[14]  Barry Cense,et al.  Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging. , 2005, Archives of ophthalmology.

[15]  F. Medeiros,et al.  Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. , 2005, American journal of ophthalmology.

[16]  D. Greenfield,et al.  Quantitative assessment of structural damage in eyes with localized visual field abnormalities. , 2004, American journal of ophthalmology.

[17]  Dirk J. Faber,et al.  Recent developments in optical coherence tomography for imaging the retina , 2007, Progress in Retinal and Eye Research.

[18]  Hiroshi Ishikawa,et al.  Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. , 2005, American journal of ophthalmology.

[19]  F. Medeiros,et al.  Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness , 2009, British Journal of Ophthalmology.

[20]  J. Fujimoto,et al.  New Technology for High‐Speed and High‐Resolution Optical Coherence Tomography a , 1998, Annals of the New York Academy of Sciences.

[21]  Teresa C. Chen,et al.  In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography. , 2004, Optics letters.

[22]  Ki Ho Park,et al.  Diagnostic ability of optical coherence tomography with a normative database to detect localized retinal nerve fiber layer defects. , 2005, Ophthalmology.

[23]  E A Swanson,et al.  Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. , 1995, Archives of ophthalmology.