Kindling in developing rats: variability of afterdischarge thresholds with age

In the kindling model, the occurrence of afterdischarges is necessary for the development of seizures. In this study, the afterdischarge thresholds of the amygdala were determined in rats of 4 different age groups, beginning with 15-day-old suckling rats. Afterdischarges were triggered in 75% of the suckling rats and in all of the rats in the older age groups. The afterdischarge thresholds varied with age, being highest in the suckling group, lowest in the 35-day-old group and intermediate in the older groups. This variability of the thresholds did not correlate with the alterations in the catecholamine levels in the amygdala that occur during maturation. The failure of 25% of suckling rats to develop afterdischarges may explain why some suckling rats do not kindle.

[1]  A. Phillips,et al.  Effects of current intensity on kindled motor seizure activity in rats. , 1974, Behavioral biology.

[2]  J. Zaide.  Differences between Tryon Bright and Dull rats in seizure activity evoked by amygdala stimulation. , 1974, Physiology & behavior.

[3]  D. Woodbury,et al.  CELLULAR AND EXTRACELLULAR SPACES IN DEVELOPING RAT BRAIN. RADIOACTIVE UPTAKE STUDIES WITH CHLORIDE AND INULIN. , 1965, Archives of neurology.

[4]  G. V. Goddard,et al.  A permanent change in brain function resulting from daily electrical stimulation. , 1969, Experimental neurology.

[5]  R. Racine,et al.  Afterdischarge Thresholds and Kindling Rates in Dorsal and Ventral Hippocampus and Dentate Gyrus , 1977, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[6]  S. T. Mason,et al.  Role of forebrain catecholamines in amygdaloid kindling , 1980, Brain Research.

[7]  P. Mareš,et al.  The Ontogenesis of Cortical Self‐Sustained After‐Discharges in Rats , 1980, Epilepsia.

[8]  R. Racine,et al.  Modification of seizure activity by electrical stimulation. II. Motor seizure. , 1972, Electroencephalography and clinical neurophysiology.

[9]  J. Engel,et al.  Long-lasting depletion of dopamine in the rat amygdala induced by kindling stimulation , 1977, Brain Research.

[10]  L. Brown,et al.  Use of microwave irradiation to prevent postmortem catecholamine metabolism: Evidence for tissue disruption artifact in a discrete region of rat brain , 1978, Brain Research.

[11]  R. Racine.  Modification of seizure activity by electrical stimulation. I. After-discharge threshold. , 1972, Electroencephalography and clinical neurophysiology.