Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas.

The association between environmentally released mercury, special education and autism rates in Texas was investigated using data from the Texas Education Department and the United States Environmental Protection Agency. A Poisson regression analysis adjusted for school district population size, economic and demographic factors was used. There was a significant increase in the rates of special education students and autism rates associated with increases in environmentally released mercury. On average, for each 1,000 lb of environmentally released mercury, there was a 43% increase in the rate of special education services and a 61% increase in the rate of autism. The association between environmentally released mercury and special education rates were fully mediated by increased autism rates. This ecological study suggests the need for further research regarding the association between environmentally released mercury and developmental disorders such as autism. These results have implications for policy planning and cost analysis.

[1]  Philip J. Landrigan,et al.  Chronic Effects of Toxic Environmental Exposures on Children's Health , 2002, Journal of toxicology. Clinical toxicology.

[2]  M. Berlin,et al.  Prolonged behavioral effects of in utero exposure to lead or methyl mercury: reduced sensitivity to changes in reinforcement contingencies during behavioral transitions and in steady state. , 1994, Toxicology and applied pharmacology.

[3]  D. Rice,et al.  Environmental factors associated with a spectrum of neurodevelopmental deficits. , 2002, Mental retardation and developmental disabilities research reviews.

[4]  L. Dales,et al.  Time trends in autism and in MMR immunization coverage in California. , 2001, Journal of the American Medical Association (JAMA).

[5]  S. Bölte,et al.  Stability and Interpersonal Agreement of the Interview-Based Diagnosis of Autism , 2001, Psychopathology.

[6]  S Bernard,et al.  Autism: a novel form of mercury poisoning. , 2001, Medical hypotheses.

[7]  Lillian V. Lee,et al.  Tagum study II: follow-up study at two years of age after prenatal exposure to mercury. , 2003, Pediatrics.

[8]  M. Brown Costs and Benefits of Enforcing Housing Policies to Prevent Childhood Lead Poisoning , 2002, Medical decision making : an international journal of the Society for Medical Decision Making.

[9]  M. Aschner,et al.  The neuropathogenesis of mercury toxicity , 2002, Molecular Psychiatry.

[10]  P. Landrigan,et al.  Environmental neurotoxic illness: research for prevention. , 1994, Environmental health perspectives.

[11]  S Clark,et al.  Evaluation of the HUD lead hazard control grant program: early overall findings. , 2001, Environmental research.

[12]  Robert S. Barcikowski,et al.  Statistical Power with Group Mean as the Unit of Analysis , 1981 .

[13]  M. Dourson,et al.  Uncertainties in the reference dose for methylmercury. , 2001, Neurotoxicology.

[14]  C. Rice,et al.  Prevalence of autism in a US metropolitan area. , 2003, JAMA.

[15]  G. Ramirez,et al.  The Tagum Study I: Analysis and Clinical Correlates of Mercury in Maternal and Cord Blood, Breast Milk, Meconium, and Infants' Hair , 2000, Pediatrics.

[16]  P. Davidson,et al.  Twenty-seven years studying the human neurotoxicity of methylmercury exposure. , 2000, Environmental research.

[17]  W. Godwin Article in Press , 2000 .

[18]  S Bernard,et al.  The role of mercury in the pathogenesis of autism , 2002, Molecular Psychiatry.

[19]  S. Bryson,et al.  Reliability and accuracy of differentiating pervasive developmental disorder subtypes. , 1998, Journal of the American Academy of Child and Adolescent Psychiatry.

[20]  M. Harada,et al.  Congenital Minamata disease: intrauterine methylmercury poisoning. , 1978, Teratology.

[21]  E. Demidenko,et al.  The association between state housing policy and lead poisoning in children. , 1999, American journal of public health.

[22]  M. Prior,et al.  Comparison of clinical symptoms in autism and Asperger's disorder. , 1996, Journal of the American Academy of Child and Adolescent Psychiatry.

[23]  D. Rice,et al.  Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. , 2000, Environmental health perspectives.

[24]  Roberta F. White,et al.  Neurotoxic risk caused by stable and variable exposure to methylmercury from seafood. , 2003, Ambulatory pediatrics : the official journal of the Ambulatory Pediatric Association.

[25]  Harvey Goldstein,et al.  A user's guide to MLwiN, Version 1.0 , 1998 .

[26]  H R Pohl,et al.  Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects—carcinogenesis, neurotoxicology, and developmental deficits in humans and animals , 1999, Toxicology and industrial health.

[27]  A. J. Gandolfi,et al.  Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. , 1995, Environmental health perspectives.

[28]  E. Cooper,et al.  Infections, Toxic Chemicals and Dietary Peptides Binding to Lymphocyte Receptors and Tissue Enzymes are Major Instigators of Autoimmunity in Autism , 2003, International journal of immunopathology and pharmacology.

[29]  Mark R. Geier,et al.  A Case-Control Study of Mercury Burden in Children with Autistic Spectrum Disorders , 2003 .

[30]  H. Needleman Behavioral toxicology. , 1995, Environmental health perspectives.

[31]  S. Hamilton Institute of Education , 2020, The Grants Register 2022.

[32]  Roberta F. White,et al.  Milestone development in infants exposed to methylmercury from human milk. , 1995, Neurotoxicology.