Left atrial shape predicts recurrence after atrial fibrillation catheter ablation

Multiple markers left atrium (LA) remodeling, including LA shape, correlate with outcomes in atrial fibrillation (AF). Catheter ablation is an important treatment of AF, but better tools are needed to determine which patients will benefit. In this study, we use particle‐based modeling to quantitatively assess LA shape, and determine to what degree it predicts AF recurrence after catheter ablation.

[1]  J B Seward,et al.  Left atrial volume: important risk marker of incident atrial fibrillation in 1655 older men and women. , 2001, Mayo Clinic proceedings.

[2]  J. Piccini,et al.  Left Atrial Remodeling: Shape Before Size? , 2013, Journal of cardiovascular electrophysiology.

[3]  E. Kholmovski,et al.  Atrial Fibrosis Helps Select the Appropriate Patient and Strategy in Catheter Ablation of Atrial Fibrillation: A DE‐MRI Guided Approach , 2011, Journal of cardiovascular electrophysiology.

[4]  Guido Gerig,et al.  Particle Based Shape Regression of Open Surfaces with Applications to Developmental Neuroimaging , 2009, MICCAI.

[5]  Martin Styner,et al.  Geometric Correspondence for Ensembles of Nonregular Shapes , 2011, MICCAI.

[6]  Manasi Datar,et al.  Statistical shape modeling of cam femoroacetabular impingement , 2013, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[7]  E. Fleck,et al.  Characteristic changes of volume and three-dimensional structure of the left atrium in different forms of atrial fibrillation: predictive value after ablative treatment , 2011, Journal of Interventional Cardiac Electrophysiology.

[8]  Nassir Marrouche,et al.  Computational Shape Models Characterize Shape Change of the Left Atrium in Atrial Fibrillation , 2014, Clinical Medicine Insights. Cardiology.

[9]  R. Tibshirani.  The lasso method for variable selection in the Cox model. , 1997, Statistics in medicine.

[10]  David Tamborero,et al.  Pre-procedural predictors of atrial fibrillation recurrence after circumferential pulmonary vein ablation. , 2007, European heart journal.

[11]  Avan Suinesiaputra,et al.  Left ventricular shape variation in asymptomatic populations: the multi-ethnic study of atherosclerosis , 2014, Journal of Cardiovascular Magnetic Resonance.

[12]  T. K. Carne,et al.  Shape and Shape Theory , 1999 .

[13]  Wolters Kluwer,et al.  Hrs/ehra/ecas Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design: a Report of the Heart Rhythm Society (hrs) Task Force , 2022 .

[14]  Alistair A. Young,et al.  Atlas-Based Quantification of Cardiac Remodeling Due to Myocardial Infarction , 2014, PloS one.

[15]  Elena Arbelo,et al.  Left Atrial Sphericity: A New Method to Assess Atrial Remodeling. Impact on the Outcome of Atrial Fibrillation Ablation , 2013, Journal of cardiovascular electrophysiology.

[16]  José Jalife,et al.  2017 HRS/EHRA/ECAS/APHRS/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation , 2012, Heart rhythm.

[17]  C. Goodall.  Procrustes methods in the statistical analysis of shape , 1991 .

[18]  Alejandro F Frangi,et al.  Computational cardiac atlases: from patient to population and back , 2009, Experimental physiology.

[19]  M. Allessie,et al.  Electrical, contractile and structural remodeling during atrial fibrillation. , 2002, Cardiovascular research.

[20]  Christopher McGann,et al.  Atrial Fibrillation Ablation Outcome Is Predicted by Left Atrial Remodeling on MRI , 2014, Circulation. Arrhythmia and electrophysiology.

[21]  Sanghamitra Mohanty,et al.  Does the left atrial appendage morphology correlate with the risk of stroke in patients with atrial fibrillation? Results from a multicenter study. , 2012, Journal of the American College of Cardiology.

[22]  Koichi Inoue,et al.  The significance of the shape of the left atrial roof as a novel index for determining the electrophysiological and structural characteristics in patients with atrial fibrillation. , 2011, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[23]  Martin Styner,et al.  Particle-Based Shape Analysis of Multi-object Complexes , 2008, MICCAI.

[24]  D. Conen,et al.  Conventional versus 3‐D Echocardiography to Predict Arrhythmia Recurrence After Atrial Fibrillation Ablation , 2017, Journal of cardiovascular electrophysiology.

[25]  Antonio De Simone,et al.  Catheter ablation treatment in patients with drug-refractory atrial fibrillation: a prospective, multi-centre, randomized, controlled study (Catheter Ablation For The Cure Of Atrial Fibrillation Study). , 2006, European heart journal.

[26]  Alistair A. Young,et al.  The Cardiac Atlas Project—an imaging database for computational modeling and statistical atlases of the heart , 2011, Bioinform..

[27]  S. Möller,et al.  Left Atrial Sphericity Index Predicts Early Recurrence of Atrial Fibrillation After Direct‐Current Cardioversion: An Echocardiographic Study , 2016, Clinical cardiology.

[28]  Yiyi Zhang,et al.  Left Atrial LGE and Arrhythmia Recurrence Following Pulmonary Vein Isolation for Paroxysmal and Persistent AF. , 2016, JACC. Cardiovascular imaging.

[29]  Martin Styner,et al.  Shape Modeling and Analysis with Entropy-Based Particle Systems , 2007, IPMI.

[30]  Andrew J Taylor,et al.  Magnetic resonance post-contrast T1 mapping in the human atrium: validation and impact on clinical outcome after catheter ablation for atrial fibrillation. , 2014, Heart rhythm.

[31]  J. Habbema,et al.  Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. , 2001, Journal of clinical epidemiology.

[32]  Joshua J. E. Blauer,et al.  Detection and Quantification of Left Atrial Structural Remodeling With Delayed-Enhancement Magnetic Resonance Imaging in Patients With Atrial Fibrillation , 2009, Circulation.

[33]  J. Brugada,et al.  Reversal of spherical remodelling of the left atrium after pulmonary vein isolation: incidence and predictors. , 2014, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[34]  M. Allessie,et al.  Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. , 1995, Circulation.

[35]  Nazem Akoum,et al.  Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study. , 2014, JAMA.