Mild cognitive impairment and its management in older people

Mild cognitive impairment (MCI) is a common condition in the elderly. It is characterized by deterioration of memory, attention, and cognitive function that is beyond what is expected based on age and educational level. MCI does not interfere significantly with individuals’ daily activities. It can act as a transitional level of evolving dementia with a range of conversion of 10%–15% per year. Thus, it is crucial to protect older people against MCI and developing dementia. The preventive interventions and appropriate treatments should improve cognitive performance, and retard or prevent progressive deficits. The avoidance of toxins, reduction of stress, prevention of somatic diseases, implementation of mental and physical exercises, as well as the use of dietary compounds like antioxidants and supplements can be protective against MCI. The modification of risk factors such as stopping smoking, as well as the treatment of deficiency in vitamins and hormones by correcting behaviors and lifestyle, can prevent cognitive decline in the elderly. The progressive increase in the growth rate of the elderly population can enhance the rate of MCI all over the world. There is no exact cure for MCI and dementia; therefore, further studies are needed in the future to determine causes of MCI and risk factors of progression from MCI to dementia. This will help to find better ways for prevention and treatment of cognitive impairment worldwide.

[1]  J. Touchon,et al.  Mild cognitive impairment: conceptual basis and current nosological status , 2000, The Lancet.

[2]  Mild Cognitive Impairment: A Clinical Approach , 2008 .

[3]  Ronald C. Petersen,et al.  Definition, course, and outcome of mild cognitive impairment , 1996 .

[4]  Azlin Baharudin,et al.  Factors associated with mild cognitive impairment among elderly patients attending medical clinics in Universiti Kebangsaan Malaysia Medical Centre , 2012 .

[5]  C. W. Tam,et al.  Screening of Mild Cognitive Impairment in Chinese Older Adults – A Multistage Validation of the Chinese Abbreviated Mild Cognitive Impairment Test , 2008, Neuroepidemiology.

[6]  G. Schellenberg,et al.  Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. , 2014, JAMA.

[7]  R. Stewart,et al.  Prevalence, Distribution, and Impact of Mild Cognitive Impairment in Latin America, China, and India: A 10/66 Population-Based Study , 2012, PLoS medicine.

[8]  R. Petersen Mild cognitive impairment as a diagnostic entity , 2004, Journal of internal medicine.

[9]  Hans Förstl,et al.  Mild cognitive impairment and dementia: the importance of modifiable risk factors. , 2011, Deutsches Arzteblatt international.

[10]  Use of cognitive enhancers for mild cognitive impairment: protocol for a systematic review and network meta-analysis , 2012, Systematic Reviews.

[11]  S. Rohana,et al.  Cognitive impairment among the elderly Malays living in rural Malaysia. , 2012, The Medical journal of Malaysia.

[12]  J. Morris,et al.  Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer’s disease , 2001, Journal of Molecular Neuroscience.

[13]  T. Odawara Cautious notification and continual monitoring of patients with mild cognitive impairment , 2012, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society.

[14]  A. Subramanyam,et al.  Mild cognitive impairment: The dilemma , 2009, Indian journal of psychiatry.

[15]  Charles DeCarli,et al.  Mild cognitive impairment: prevalence, prognosis, aetiology, and treatment , 2003, The Lancet Neurology.

[16]  M. Albert,et al.  Amnestic MCI or prodromal Alzheimer's disease? , 2004, The Lancet Neurology.

[17]  T. Hamid,et al.  The Effects of Sleep Quality, Physical Activity, and Environmental Quality on the Risk of Falls in Dementia , 2013, American journal of Alzheimer's disease and other dementias.

[18]  R. Petersen,et al.  Mild cognitive impairment , 2006, The Lancet.

[19]  J. Ellison A 60-year-old woman with mild memory impairment: review of mild cognitive impairment. , 2008, JAMA.

[20]  Muireann Irish,et al.  Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation , 2011, BMC Neuroscience.

[21]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[22]  M. Austrom,et al.  Long term caregiving: helping families of persons with mild cognitive impairment cope. , 2009, Current Alzheimer research.

[23]  A. Castel,et al.  Memory in Elderly People , 2002 .

[24]  J. Morris,et al.  Current concepts in mild cognitive impairment. , 2001, Archives of neurology.

[25]  H. Arrighi,et al.  Mild cognitive impairment: Disparity of incidence and prevalence estimates , 2012, Alzheimer's & Dementia.

[26]  J. George,et al.  Cognitive assessment in the elderly: a review of clinical methods. , 2007, QJM : monthly journal of the Association of Physicians.

[27]  K. Blennow,et al.  CSF biomarkers for mild cognitive impairment and early Alzheimer's disease , 2005, Clinical Neurology and Neurosurgery.

[28]  K. Nakashima,et al.  Prevalence of Dementia and Mild Cognitive Impairment in the Rural Island Town of Ama-cho, Japan , 2012, Dementia and Geriatric Cognitive Disorders Extra.

[29]  S. Riedel-Heller,et al.  Progression of mild cognitive impairment to dementia: a challenge to current thinking. , 2006, The British journal of psychiatry : the journal of mental science.

[30]  E. Tangalos,et al.  Mild Cognitive Impairment Clinical Characterization and Outcome , 1999 .

[31]  As Ramli,et al.  Diagnosis and Management of Mild Cognitive Impairment in the Community: What is the Role of Primary Care Physician? , 2011, Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia.

[32]  P. Sachdev,et al.  Plasma biomarkers for mild cognitive impairment and Alzheimer's disease , 2009, Brain Research Reviews.

[33]  V. Pankratz,et al.  Physical exercise, aging, and mild cognitive impairment: a population-based study. , 2010, Archives of neurology.

[34]  M. Mullan,et al.  Plasma microRNA biomarkers for detection of mild cognitive impairment , 2012, Aging.

[35]  J. Cerhan,et al.  Vegetables, Unsaturated Fats, Moderate Alcohol Intake, and Mild Cognitive Impairment , 2010, Dementia and Geriatric Cognitive Disorders.

[36]  T. Hamid,et al.  Does substance abuse contribute to further risk of falls in dementia , 2014, Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition.

[37]  W. Dale,et al.  High Interest in Screening and Treatment for Mild Cognitive Impairment in Older Adults: A Pilot Study , 2006, Journal of the American Geriatrics Society.

[38]  C. Jack,et al.  Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects , 2010, Alzheimer's & Dementia.

[39]  J. Becker,et al.  Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. , 2007, Archives of neurology.

[40]  K. Blennow CSF biomarkers for mild cognitive impairment , 2004, Journal of internal medicine.

[41]  Deborah Blacker,et al.  Mild cognitive impairment and dementia. , 2006, Annual review of clinical psychology.

[42]  R. Caselli,et al.  Current epidemiology of mild cognitive impairment and other predementia syndromes. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[43]  Nicolas Farina,et al.  Vitamin E for Alzheimer's dementia and mild cognitive impairment. , 2017, The Cochrane database of systematic reviews.

[44]  R. Mayeux,et al.  Use of genetic variation as biomarkers for mild cognitive impairment and progression of mild cognitive impairment to dementia. , 2010, Journal of Alzheimer's disease : JAD.

[45]  R. Rajikan,et al.  Antioxidant intake and mild cognitive impairment among elderly people in klang valley: A pilot study , 2010 .

[46]  A. Kluger,et al.  Clinical features of MCI: motor changes , 2008, International Psychogeriatrics.

[47]  S. Ferris,et al.  Age‐associated memory impairment: Proposed diagnostic criteria and measures of clinical change — report of a national institute of mental health work group , 1986 .