Saccadic eye movement applications for psychiatric disorders

Objective The study presented here analyzed the patterns of relationship between oculomotor performance and psychopathology, focusing on depression, bipolar disorder, schizophrenia, attention-deficit hyperactivity disorder, and anxiety disorder. Methods Scientific articles published from 1967 to 2013 in the PubMed/Medline, ISI Web of Knowledge, Cochrane, and SciELO databases were reviewed. Results Saccadic eye movement appears to be heavily involved in psychiatric diseases covered in this review via a direct mechanism. The changes seen in the execution of eye movement tasks in patients with psychopathologies of various studies confirm that eye movement is associated with the cognitive and motor system. Conclusion Saccadic eye movement changes appear to be heavily involved in the psychiatric disorders covered in this review and may be considered a possible marker of some disorders. The few existing studies that approach the topic demonstrate a need to improve the experimental paradigms, as well as the methods of analysis. Most of them report behavioral variables (latency/reaction time), though electrophysiological measures are absent.

[1]  Brett A. Clementz,et al.  Inhibitory deficits in ocular motor behavior in adults with attention-deficit/hyperactivity disorder , 2004, Biological Psychiatry.

[2]  D. Munoz,et al.  Look away: the anti-saccade task and the voluntary control of eye movement , 2004, Nature Reviews Neuroscience.

[3]  K. Johnston,et al.  Neurophysiology and neuroanatomy of reflexive and voluntary saccades in non-human primates , 2008, Brain and Cognition.

[4]  K. Velanova,et al.  Development of eye-movement control , 2008, Brain and Cognition.

[5]  R. John Leigh,et al.  Disorders of saccades , 2007, Current neurology and neuroscience reports.

[6]  Janet B W Williams,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[7]  C. Karatekin.  Improving antisaccade performance in adolescents with attention-deficit/hyperactivity disorder (ADHD) , 2006, Experimental Brain Research.

[8]  M. Krebs,et al.  Memory-guided saccade abnormalities in schizophrenic patients and their healthy, full biological siblings , 2007, Psychological Medicine.

[9]  J. John Mann,et al.  Prefrontal and Cerebellar Abnormalities in Major Depression: Evidence from Oculomotor Studies , 1998, Biological Psychiatry.

[10]  L. Simo,et al.  Functional neuroanatomy of anticipatory behavior: dissociation between sensory-driven and memory-driven systems. , 2005, Cerebral cortex.

[11]  J. Sweeney,et al.  Response-inhibition deficits in obsessive-compulsive disorder: an indicator of dysfunction in frontostriatal circuits. , 1997, Journal of psychiatry & neuroscience : JPN.

[12]  C. Kennard.  Disorders of higher gaze control. , 2011, Handbook of clinical neurology.

[13]  K. Hoffmann,et al.  Motion perception during saccades , 1993, Vision Research.

[14]  M. Eysenck,et al.  Anxiety, inhibition, efficiency, and effectiveness. An investigation using antisaccade task. , 2009, Experimental psychology.

[15]  Paul G Overton,et al.  Collicular dysfunction in attention deficit hyperactivity disorder. , 2008, Medical hypotheses.

[16]  G. R. Barnes,et al.  Quantitative differences in smooth pursuit and saccadic eye movements , 2006, Experimental Brain Research.

[17]  Yiping P. Du,et al.  Cerebellar hyperactivity during smooth pursuit eye movements in bipolar disorder. , 2011, Journal of psychiatric research.

[18]  Hao Yan,et al.  Neuroanatomical Circuitry Associated with Exploratory Eye Movement in Schizophrenia: A Voxel-Based Morphometric Study , 2011, PloS one.

[19]  D. Levy,et al.  Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[20]  C. Stefanis,et al.  Antisaccade performance of 1,273 men: effects of schizotypy, anxiety, and depression. , 2003, Journal of abnormal psychology.

[21]  J. Henderson,et al.  Attentional versus motor inhibition in adults with attention-deficit/hyperactivity disorder. , 2006, Neuropsychology.

[22]  B. Steinacher,et al.  Smooth pursuit eye movements of patients with schizophrenia and affective disorder during clinical treatment , 2002, European Archives of Psychiatry and Clinical Neuroscience.

[23]  D. Hommer,et al.  Altered performance on an ocular fixation task in attention-deficit/hyperactivity disorder , 2001, Biological Psychiatry.

[24]  K. R. Ridderinkhof,et al.  Neurocognitive mechanisms of cognitive control: The role of prefrontal cortex in action selection, response inhibition, performance monitoring, and reward-based learning , 2004, Brain and Cognition.

[25]  G. Zaccara,et al.  Smooth-pursuit eye movement and saccadic intrusions in obsessive-compulsive disorder , 1996, Biological Psychiatry.

[26]  Michael G. Hardin,et al.  Cognitive Control Under Contingencies in Anxious and Depressed Adolescents: An Antisaccade Task , 2005, Biological Psychiatry.

[27]  D. Gooding,et al.  Temporal stability of saccadic task performance in schizophrenia and bipolar patients , 2004, Psychological Medicine.

[28]  N. Smyrnis,et al.  Larger variability of saccadic reaction times in schizophrenia patients , 2009, Psychiatry Research.

[29]  F Jagla,et al.  Saccadic eye movement related potentials. , 2007, Physiological research.

[30]  A. Richards,et al.  Effects of anxiety on task switching: Evidence from the mixed antisaccade task , 2008, Cognitive, affective & behavioral neuroscience.

[31]  Stefan Van der Stigchel,et al.  A review on eye movement studies in childhood and adolescent psychiatry , 2008, Brain and Cognition.

[32]  Robert M. McPeek,et al.  Deficits in saccade target selection after inactivation of superior colliculus , 2004, Nature Neuroscience.

[33]  Sang Ki Park,et al.  Depression research: where are we now? , 2010, Molecular Brain.

[34]  Norbert Kathmann,et al.  Deficits in gain of smooth pursuit eye movements in schizophrenia and affective disorder patients and their unaffected relatives. , 2003, The American journal of psychiatry.

[35]  G. Kinrys,et al.  [Anxiety disorders in women: does gender matter to treatment?]. , 2005, Revista brasileira de psiquiatria.

[36]  D. Levy,et al.  Relatives of unipolar and bipolar patients have normal pursuit , 1983, Psychiatry Research.

[37]  Dominic W. Hughes,et al.  Eye-Tracking Patterns in Schizophrenia , 1973, Science.

[38]  C. Tamminga,et al.  Schizophrenia: treatment targets beyond monoamine systems. , 2011, Annual review of pharmacology and toxicology.

[39]  J. Kwon,et al.  Diagnostic stability of first-episode psychosis and predictors of diagnostic shift from non-affective psychosis to bipolar disorder: A retrospective evaluation after recurrence , 2011, Psychiatry Research.

[40]  K. Fukushima,et al.  Disturbances of voluntary control of saccadic eye movements in schizophrenic patients , 1988, Biological Psychiatry.

[41]  S. Everling,et al.  The antisaccade: a review of basic research and clinical studies , 1998, Neuropsychologia.

[42]  C. Grillon,et al.  The impact of induced anxiety on response inhibition , 2012, Front. Hum. Neurosci..

[43]  C. Klein,et al.  Development of pro- and antisaccades in children with attention-deficit hyperactivity disorder (ADHD) and healthy controls. , 2003, Psychophysiology.

[44]  A. Fuchs.  Saccadic and smooth pursuit eye movements in the monkey , 1967, The Journal of physiology.

[45]  K. Tallent,et al.  The association between antisaccade task and working memory task performance in schizophrenia and bipolar disorder. , 2001, The Journal of nervous and mental disease.

[46]  P. Snyder,et al.  Cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder , 2006, Neuroscience & Biobehavioral Reviews.

[47]  J. Sweeney,et al.  Pharmacological treatment effects on eye movement control , 2008, Brain and Cognition.

[48]  N. Swerdlow,et al.  Ocular motor responses to unpredictable and predictable smooth pursuit stimuli among patients with obsessive-compulsive disorder. , 1996, Journal of psychiatry & neuroscience : JPN.

[49]  G. Thaker,et al.  Neurophysiological endophenotypes across bipolar and schizophrenia psychosis. , 2007, Schizophrenia bulletin.

[50]  B. Millet,et al.  A critical review of the contribution of eye movement recordings to the neuropsychology of obsessive compulsive disorder , 2011, Acta psychiatrica Scandinavica.

[51]  J. Hoffman,et al.  The role of visual attention in saccadic eye movements , 1995, Perception & psychophysics.

[52]  Saumil S. Patel,et al.  Effects of adjunct valproic acid on clinical symptoms and saccadic eye movements in schizophrenia , 2011, Human psychopharmacology.

[53]  Michael G. Hardin,et al.  Perturbed reward processing in pediatric bipolar disorder: an antisaccade study , 2010, Journal of psychopharmacology.

[54]  K. Konrad,et al.  Oculomotor inhibition in children with and without attention-deficit hyperactivity disorder (ADHD) , 2006, Journal of Neural Transmission.

[55]  H. Westenberg,et al.  Saccadic abnormalities in psychotropic-naive obsessive–compulsive disorder without co-morbidity , 2006, Psychological Medicine.

[56]  G. Pearlson,et al.  Eye Movements and Psychopathology in Schizophrenia and Bipolar Disorder , 1996, The Journal of nervous and mental disease.

[57]  P. Cuijpers,et al.  Prevention of major depression. , 2010, Annual review of clinical psychology.

[58]  P. Maruff,et al.  Abnormalities of internally generated saccades in obsessive–compulsive disorder , 1999, Psychological Medicine.

[59]  J. Theeuwes,et al.  Deficits in visuo-spatial working memory, inhibition and oculomotor control in boys with ADHD and their non-affected brothers , 2008, Journal of Neural Transmission.

[60]  L. Bour,et al.  Increased saccadic rate during smooth pursuit eye movements in patients at Ultra High Risk for developing a psychosis , 2010, Brain and Cognition.

[61]  D. Levy,et al.  Smooth pursuit eye movements, attention, and schizophrenia. , 1976, Archives of general psychiatry.

[62]  B. Clementz,et al.  The effect of fixation condition manipulations on antisaccade performance in schizophrenia: studies of diagnostic specificity , 1997, Experimental Brain Research.

[63]  B. Reuter,et al.  Impaired volitional saccade control: first evidence for a new candidate endophenotype in obsessive–compulsive disorder , 2013, European Archives of Psychiatry and Clinical Neuroscience.

[64]  G. Barnes,et al.  Brain and behavior: a task-dependent eye movement study. , 2008, Cerebral cortex.

[65]  P. Fitzgerald,et al.  Ocular motor differences between melancholic and non-melancholic depression. , 2006, Journal of affective disorders.

[66]  B. Clementz,et al.  Neurophysiology and neuroanatomy of reflexive and volitional saccades: Evidence from studies of humans , 2008, Brain and Cognition.

[67]  W. Heide,et al.  Evidence from increased anticipation of predictive saccades for a dysfunction of fronto-striatal circuits in obsessive–compulsive disorder , 2006, Psychiatry Research.

[68]  S. Hutton,et al.  The antisaccade task as a research tool in psychopathology: a critical review. , 2006, Psychophysiology.

[69]  M. Thase,et al.  Response suppression deficits in treatment-naïve first-episode patients with schizophrenia, psychotic bipolar disorder and psychotic major depression , 2009, Psychiatry Research.

[70]  L. Siever,et al.  Eye-tracking, attention and amphetamine challenge. , 1987, Journal of psychiatric research.

[71]  Anne B. Sereno,et al.  Antisaccades and smooth pursuit eye movements in schizophrenia , 1995, Biological Psychiatry.

[72]  M. Corbetta,et al.  A Common Network of Functional Areas for Attention and Eye Movements , 1998, Neuron.

[73]  Nick Berggren,et al.  Affective attention under cognitive load: reduced emotional biases but emergent anxiety-related costs to inhibitory control , 2013, Front. Hum. Neurosci..

[74]  D. Levy,et al.  Differences in cerebral activation during smooth pursuit and saccadic eye movements using positron-emission tomography , 1998, Biological Psychiatry.

[75]  S. Surguladze,et al.  Emerging treatments in the management of bipolar disorder – focus on risperidone long acting injection , 2010, Neuropsychiatric disease and treatment.

[76]  N. Swerdlow,et al.  Characteristics of open- and closed-loop smooth pursuit responses among obsessive-compulsive disorder, schizophrenia, and nonpsychiatric individuals. , 1997, Psychophysiology.

[77]  P. Stoeter,et al.  Anatomical correlates of ocular motor deficits in cerebellar lesions. , 2009, Brain : a journal of neurology.

[78]  H. Spohn,et al.  Recent studies of psychophysiology in schizophrenia. , 1979, Schizophrenia bulletin.

[79]  W. Heide,et al.  Smooth pursuit deficits in schizophrenia, affective disorder and obsessive–compulsive disorder , 2004, Psychological Medicine.

[80]  Masao Aihara,et al.  Saccade eye movements as a quantitative measure of frontostriatal network in children with ADHD , 2010, Brain and Development.

[81]  D. Munoz,et al.  Altered control of visual fixation and saccadic eye movements in attention-deficit hyperactivity disorder. , 2003, Journal of neurophysiology.

[82]  A. Jablensky,et al.  Revisiting the suitability of antisaccade performance as an endophenotype in schizophrenia , 2011, Brain and Cognition.

[83]  Michele A. Basso,et al.  The tell-tale tasks: A review of saccadic research in psychiatric patient populations , 2008, Brain and Cognition.

[84]  K. Hoffmann,et al.  Neural Dynamics of Saccadic Suppression , 2009, Journal of Neuroscience.

[85]  R. Freedman,et al.  Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder. , 2007, The American journal of psychiatry.

[86]  C. S. Hendershot,et al.  Fixation stability in schizophrenia, bipolar, and control subjects , 2000, Psychiatry Research.

[87]  J. Mazer.  Spatial Attention, Feature-Based Attention, and Saccades: Three Sides of One Coin? , 2011, Biological Psychiatry.

[88]  U. Bogdahn,et al.  Differences in cortical activation during smooth pursuit and saccadic eye movements following cerebellar lesions , 2007, Experimental Brain Research.

[89]  P. Pauli,et al.  Probing the attentional control theory in social anxiety: An emotional saccade task , 2009, Cognitive, affective & behavioral neuroscience.

[90]  J. Rabe-Jabłońska,et al.  [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders]. , 1993, Psychiatria polska.

[91]  John M. Findlay,et al.  Saccade target selection: Do distractors affect saccade accuracy? , 2009, Vision Research.

[92]  M. Krebs,et al.  Correlates between neurological soft signs and saccadic parameters in schizophrenia , 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[93]  J. Henderson,et al.  Cognitive Control and Attentional Selection in Adolescents with ADHD Versus ADD , 2010, Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53.

[94]  L. Crevits,et al.  Effect of repetitive transcranial magnetic stimulation on saccades in depression: A pilot study , 2005, Psychiatry Research.

[95]  M. Fillmore,et al.  Does response variability predict distractibility among adults with attention-deficit/hyperactivity disorder? , 2011, Psychological assessment.

[96]  J. Chen,et al.  Differential attentional bias in generalized anxiety disorder and panic disorder , 2013, Neuropsychiatric disease and treatment.

[97]  B. Steinacher,et al.  Basic parameters of saccadic eye movements – differences between unmedicated schizophrenia and affective disorder patients , 2001, European Archives of Psychiatry and Clinical Neuroscience.

[98]  Paul B. Fitzgerald,et al.  Self-paced and reprogrammed saccades: Differences between melancholic and non-melancholic depression , 2006, Neuroscience Research.