Vital biomechanics: Proposed general concepts for skeletal adaptations to mechanical usage

From presently known facts this text synthesizes and proposes some seminal and in some respects novel concepts that concern how mechanical factors influence skeletal architecture during the period between birth and skeletal maturity. The concepts include a proposed design criterion for healthy growing skeletons and their load-bearing bony, cartilaginous, and fibrous tissues and organs, plus the biologic means and possible design purposes behind it. They also identify knowledge gaps marked thus (**) that future research should fill. The concepts would apply to healthy growing mammal ian ske le tons , and with some added nuances, to avian, amphibian, and reptilian ones too. Unless stated otherwise, the discussion concerns physiology, not pathology, as those biologic domains are defined later in the Comments section. A brief Glossary at the end of the text defines terms used.

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