Enhancement of Dissolution Rate of Irbesartan by Chitosan based Crystal Engineering Technique

0chitosan on drug crystals. The precipitate obtained was filtered through Whatmann No. 1 filter paper using vacuum filtration unit and dried at 45 C for 24 h. The prepared cocrystals were characterized in terms of saturation solubility, drug content, infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), in vitro dissolution studies and stability studies. The considerable improvement in the dissolution rate of drug from optimized co-crystal formulation was attributed to the decreased drug crystallinity, altered surface morphology and reduction in particle size. The 0.2% chitosan and 0.4% chitosan chlorhydrate were found to be optimized concentrations for enhancement of dissolution rate of irbesartan. The technique is scalable and may prove valuable in manufacturing process in future for enhancement of dissolution of poorly water soluble drugs.

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