Dibasic non-imidazole histamine H3 receptor antagonists with a rigid biphenyl scaffold.

[1]  G. Fox,et al.  Histamine H3 receptor antagonists: preclinical promise for treating obesity and cognitive disorders. , 2006, Molecular interventions.

[2]  M. Impicciatore,et al.  Discovery of histamine H3 receptor antagonistic property of simple imidazole-free derivatives: Preliminary pharmacological investigation. , 2006, Pharmacological research.

[3]  M. Mor,et al.  Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series. , 2006, Bioorganic & medicinal chemistry.

[4]  Rob Leurs,et al.  Keynote review: histamine H3 receptor antagonists reach out for the clinic. , 2005, Drug discovery today.

[5]  Silvia Rivara,et al.  Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists. , 2005, Bioorganic & medicinal chemistry.

[6]  R. Leurs,et al.  The histamine H3 receptor: from gene cloning to H3 receptor drugs , 2005, Nature Reviews Drug Discovery.

[7]  Sylvain Crochet,et al.  The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders. , 2004, Trends in pharmacological sciences.

[8]  Matthew P. Repasky,et al.  Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. , 2004, Journal of medicinal chemistry.

[9]  C. Dvorak,et al.  A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines. , 2003, Journal of medicinal chemistry.

[10]  A. Hancock,et al.  Molecular modeling and pharmacological analysis of species-related histamine H3 receptor heterogeneity , 2003, Neuropharmacology.

[11]  J. Binet,et al.  Structure activity relationships of new inhibitors of mammalian 2,3-oxidosqualene cyclase designed from isoquinoline derivatives. , 2002, Chemical & pharmaceutical bulletin.

[12]  L B Hough,et al.  Genomics meets histamine receptors: new subtypes, new receptors. , 2001, Molecular pharmacology.

[13]  D. Jenkinson,et al.  Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel. , 2000, Journal of medicinal chemistry.

[14]  M. Jackson,et al.  Cloning and functional expression of the human histamine H3 receptor. , 1999, Molecular pharmacology.

[15]  J. Schwartz,et al.  [125I]iodoproxyfan, a new antagonist to label and visualize cerebral histamine H3 receptors. , 1994, The Journal of pharmacology and experimental therapeutics.

[16]  N. Oudart,et al.  Effect of an Histaminergic H3 Agonist on the Non‐adrenergic Non‐cholinergic Contraction in Guinea‐pig Perfused Bronchioles , 1993, The Journal of pharmacy and pharmacology.

[17]  Gavin Kilpatrick,et al.  Histamine H3 receptors modulate the release of [3H]‐acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes , 1992, British journal of pharmacology.

[18]  E. Schlicker,et al.  Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein by presynaptic histamine H3 receptors , 1992, Naunyn-Schmiedeberg's Archives of Pharmacology.

[19]  J. Schwartz,et al.  Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor , 1983, Nature.

[20]  Y. Cheng,et al.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. , 1973, Biochemical pharmacology.

[21]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.

[22]  K. Fink,et al.  Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors , 2005, Journal of Neural Transmission / General Section JNT.

[23]  M. Impicciatore,et al.  Pharmacological profile of new thioperamide derivatives at histamine peripheral H1-, H2-, H3-receptors in guinea-pig , 2005, Agents and Actions.

[24]  M. Mor,et al.  Heteroarylaminoethyl and heteroarylthioethyl imidazoles. Synthesis and H3-receptor affinity , 1995 .