Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission

[1]  Ann E. Frazier,et al.  MiD49 and MiD51, new components of the mitochondrial fission machinery , 2011, EMBO reports.

[2]  R. Youle,et al.  Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells , 2010, The Journal of cell biology.

[3]  Benedikt Westermann,et al.  Mitochondrial fusion and fission in cell life and death , 2010, Nature Reviews Molecular Cell Biology.

[4]  Armin Giese,et al.  Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1 , 2010, The EMBO journal.

[5]  C. Blackstone,et al.  A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division* , 2010, The Journal of Biological Chemistry.

[6]  B. Westermann.  Mitochondrial dynamics in model organisms: what yeasts, worms and flies have taught us about fusion and fission of mitochondria. , 2010, Seminars in cell & developmental biology.

[7]  C. Blackstone,et al.  Dynamic regulation of mitochondrial fission through modification of the dynamin‐related protein Drp1 , 2010, Annals of the New York Academy of Sciences.

[8]  J. Nunnari,et al.  Small molecule inhibitors of mitochondrial division: tools that translate basic biological research into medicine. , 2010, Chemistry & biology.

[9]  L. Scorrano,et al.  Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation , 2010, Cell Death and Differentiation.

[10]  Marc Liesa,et al.  Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. , 2009, The international journal of biochemistry & cell biology.

[11]  T. Kensler,et al.  The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice , 2009, The Journal of cell biology.

[12]  A. Reichert,et al.  Emerging roles of mitochondrial membrane dynamics in health and disease , 2009, Biological chemistry.

[13]  Satoshi O. Suzuki,et al.  Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice , 2009, Nature Cell Biology.

[14]  O. Shupliakov,et al.  The novel conserved mitochondrial inner-membrane protein MTGM regulates mitochondrial morphology and cell proliferation , 2009, Journal of Cell Science.

[15]  Marc Liesa,et al.  Mitochondrial dynamics in mammalian health and disease. , 2009, Physiological reviews.

[16]  S. Sheu,et al.  Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. , 2009, Journal of molecular and cellular cardiology.

[17]  P. Reddy,et al.  Mitochondrial structural and functional dynamics in Huntington's disease , 2009, Brain Research Reviews.

[18]  George Perry,et al.  The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease , 2009, Journal of neurochemistry.

[19]  J. Martinou,et al.  Mitochondrial dynamics and cancer. , 2009, Seminars in cancer biology.

[20]  M. Mattson,et al.  Mitochondria in Neuroplasticity and Neurological Disorders , 2008, Neuron.

[21]  C. Lelliott,et al.  Mitochondrial Fusion Is Increased by the Nuclear Coactivator PGC-1β , 2008, PloS one.

[22]  P. Bernardi,et al.  Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria , 2008, Proceedings of the National Academy of Sciences.

[23]  A. Nairn,et al.  CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology , 2008, The Journal of cell biology.

[24]  S. Frank,et al.  Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1 , 2008, IUBMB life.

[25]  G. Perkins,et al.  Mitochondrial fragmentation in neurodegeneration , 2008, Nature Reviews Neuroscience.

[26]  R. Youle,et al.  Mitochondrial dynamics and apoptosis. , 2008, Genes & development.

[27]  A. M. van der Bliek,et al.  The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. , 2008, Molecular biology of the cell.

[28]  Fernando J. Pineda,et al.  Mitochondrial fission and fusion dynamics: the long and short of it , 2008, Cell Death and Differentiation.

[29]  S. Strack,et al.  Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death , 2007, EMBO reports.

[30]  B. Westermann,et al.  Molecular machinery of mitochondrial dynamics in yeast , 2007, Biological chemistry.

[31]  C. Blackstone,et al.  Cyclic AMP-dependent Protein Kinase Phosphorylation of Drp1 Regulates Its GTPase Activity and Mitochondrial Morphology* , 2007, Journal of Biological Chemistry.

[32]  Y. Yoon,et al.  Mitochondrial clustering induced by overexpression of the mitochondrial fusion protein Mfn2 causes mitochondrial dysfunction and cell death. , 2007, European journal of cell biology.

[33]  J. Nunnari.  The machines that divide and fuse mitochondria , 2007, Annual review of biochemistry.

[34]  G. Attardi,et al.  Identification of a Novel Mitochondrial Complex Containing Mitofusin 2 and Stomatin-like Protein 2* , 2007, Journal of Biological Chemistry.

[35]  D. Chan.  Mitochondrial fusion and fission in mammals. , 2006, Annual review of cell and developmental biology.

[36]  J. Shaw,et al.  Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes. , 2005, Annual review of genetics.

[37]  Y. Yoon,et al.  Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1 , 2005, Journal of Cell Science.

[38]  Erik E. Griffin,et al.  The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria , 2005, The Journal of cell biology.

[39]  D. Chan,et al.  Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction* , 2005, Journal of Biological Chemistry.

[40]  R. Youle,et al.  Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. , 2004, Molecular biology of the cell.

[41]  J. Modica-Napolitano,et al.  Mitochondrial dysfunction in cancer. , 2004, Mitochondrion.

[42]  C. Blackstone,et al.  Intra- and Intermolecular Domain Interactions of the C-terminal GTPase Effector Domain of the Multimeric Dynamin-like GTPase Drp1* , 2004, Journal of Biological Chemistry.

[43]  J. McCaffery,et al.  Structural Basis of Mitochondrial Tethering by Mitofusin Complexes , 2004, Science.

[44]  N. Tjandra,et al.  The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. , 2003, Journal of molecular biology.

[45]  J. Martinou,et al.  hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery* , 2003, Journal of Biological Chemistry.

[46]  K. Mihara,et al.  Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. , 2003, Journal of biochemistry.

[47]  M. McNiven,et al.  The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1 , 2003, Molecular and Cellular Biology.

[48]  J. Nunnari,et al.  The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission , 2002, The Journal of cell biology.

[49]  M. McNiven,et al.  Mammalian dynamin-like protein DLP1 tubulates membranes. , 2001, Molecular biology of the cell.

[50]  A. M. van der Bliek,et al.  Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. , 2001, Molecular biology of the cell.

[51]  J. Shaw,et al.  Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p , 2000, The Journal of cell biology.

[52]  J. Nunnari,et al.  Mdv1p Is a Wd Repeat Protein That Interacts with the Dynamin-Related Gtpase, Dnm1p, to Trigger Mitochondrial Division , 2000, The Journal of cell biology.

[53]  J. Grosgeorge,et al.  Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy , 2000, Nature Genetics.

[54]  A. Poustka,et al.  Systematic subcellular localization of novel proteins identified by large‐scale cDNA sequencing , 2000, EMBO reports.

[55]  A. M. van der Bliek,et al.  A Human Dynamin-related Protein Controls the Distribution of Mitochondria , 1998, The Journal of cell biology.

[56]  S. Ho,et al.  Site-directed mutagenesis by overlap extension using the polymerase chain reaction. , 1989, Gene.

[57]  P. Beech,et al.  Cell biology of mitochondrial dynamics. , 2006, International review of cytology.