Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension: Guyton Revisited Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney. Proc Natl Acad Sci U S A 103: 17985–17990, 2006

![Figure][1] Eberhard Ritz Feature Editor The late Arthur Guyton had postulated that even in the absence of primary renal disease of the kidney, a change in renal function, more precise, resetting of the BP/natriuresis relationship, is a prerequisite for a persistent rise of BP ([1][2],[2

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