Severe ethylene glycol ingestion treated without hemodialysis.

Fomepizole (4-methylpyrazole, Antizol) is being increasingly used in the treatment of ethylene glycol toxicity in adults. Little experience exists with this drug, however, in the pediatric population. We present a case of ethylene glycol poisoning in a child where use of fomepizole averted intravenous ethanol infusion and hemodialysis, limited the duration of intensive care monitoring, and decreased the overall cost of treatment.

[1]  K. McMartin,et al.  Fomepizole for the treatment of ethylene glycol poisoning. Methylpyrazole for Toxic Alcohols Study Group. , 1999, The New England journal of medicine.

[2]  W. Watson,et al.  American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Ethylene Glycol Poisoning. Ad Hoc Committee. , 1999, Journal of toxicology. Clinical toxicology.

[3]  M. Shannon.  Toxicology reviews: fomepizole--a new antidote. , 1998, Pediatric emergency care.

[4]  K. McMartin,et al.  Treatment of methanol poisoning with intravenous 4-methylpyrazole. , 1997, Annals of emergency medicine.

[5]  R. Chabali.  Diagnostic use of anion and osmolal gaps in pediatric emergency medicine. , 1997, Pediatric emergency care.

[6]  T. Litovitz,et al.  1998 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. , 1999, The American journal of emergency medicine.

[7]  R. Garnier,et al.  Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. , 1988, The New England journal of medicine.

[8]  D. Feinfeld,et al.  Clearance of ethylene glycol by kidneys and hemodialysis. , 1987, Journal of toxicology. Clinical toxicology.

[9]  P. Gabow,et al.  Organic acids in ethylene glycol intoxication. , 1986, Annals of internal medicine.

[10]  A. Manoguerra,et al.  Short-term hemodialysis in childhood ethylene glycol poisoning. , 1986, The Journal of pediatrics.

[11]  R. Garnier,et al.  4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. , 1986, Journal of toxicology. Clinical toxicology.

[12]  W. Keane,et al.  Ethylene glycol poisoning: pharmacokinetics during therapy with ethanol and hemodialysis. , 1981, The New England journal of medicine.

[13]  K. Lindros,et al.  Ethanol‐induced hypoglycaemia in man: its suppression by the alcohol dehydrogenase inhibitor 4‐methylpyrazole , 1977, European journal of clinical investigation.