Characterization of DNA-Nanopore Interactions by Molecular Dynamics

A major challenge in using solid-state nanopores for DNA detection and sequencing is the molecular selectivity and sensitivity resolution through proper control of DNA-nanopore interface. This paper explores the interaction mechanisms between DNA and nanopores through molecular dynamics simulations. The DNA translocation dynamics through nanopores of various diameters and under various applied biasvoltages are characterized. Such property-function relationship can be used for the optimal designs of the lab-on-chip DNA diagnostic devices.

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