Spin echo 31P spectroscopic imaging in the human brain

Spectroscopic imaging of phosphorus metabolites in the human brain has been carried out with two data acquisition methods: by observation of the free induction decay (FID) signal and by a short spin echo sequence. The resultant spectral images and spatially resolved spectra are compared. Spin echo observation is found to provide spectra of superior quality, and by suitably selecting the sequence timing, no significant increase in T2 losses, as compared with the FID method, is encountered. 31P images with approximately 3.5 cm spatial resolution are obtained within times of 37 min at 2.0 T field strength. © 1990 Academic Press, Inc.

[1]  M. Weiner,et al.  Computer simulation of MRS localization techniques: An analysis of ISIS , 1989, Magnetic resonance in medicine.

[2]  Andrew A. Maudsley,et al.  Sensitivity in fourier imaging , 1986 .

[3]  M. Weiner,et al.  Application of image-guided surface coil P-31 MR spectroscopy to human liver, heart, and kidney. , 1988, Radiology.

[4]  B. Hubesch,et al.  Phosphorus‐31 magnetic resonance spectroscopy in humans by spectroscopic imaging: Localized spectroscopy and metabolite imaging , 1989, Magnetic resonance in medicine.

[5]  G A Holland,et al.  Integrated MR imaging and spectroscopy with chemical shift imaging of P-31 at 1.5 T: initial clinical experience. , 1988, Radiology.

[6]  Richard R. Ernst,et al.  Sensitivity and performance time in NMR imaging , 1979 .

[7]  Graeme M. Bydder,et al.  Localized phosphorus-31 NMR spectroscopy of normal and pathological human organs in vivo using phase-encoding techniques , 1987 .

[8]  Britton Chance,et al.  In vivo one-dimensional imaging of phosphorus metabolites by phosphorus-31 nuclear magnetic resonance. , 1983 .

[9]  J. E. Klein,et al.  Characterization of MR spectroscopic imaging of the human head and limb at 2.0 T. , 1988, Radiology.

[10]  G A Holland,et al.  A simple method for processing NMR spectra in which acquisition is delayed: Applications to in vivo localized 31P NMR spectra acquired using the DRESS technique , 1988, Magnetic resonance in medicine.

[11]  S K Hilal,et al.  In vivo MR spectroscopic imaging with P-31. Work in progress. , 1984, Radiology.

[12]  K. Uğurbil,et al.  NMR chemical shift imaging in three dimensions. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[13]  B. Ross,et al.  Lineshapes in phase-encoded spectroscopic imaging experiments , 1987 .

[14]  W. Perman,et al.  Spatially resolved high resolution spectroscopy by “four-dimensional” NMR , 1983 .

[15]  Truman R. Brown,et al.  The accuracy of quantification from 1D NMR spectra using the PIQABLE algorithm , 1989 .