Review article: management issues in acid-related disorders in the elderly

The population of Japan is rapidly ageing and this, along with the Westernization of the diet, is expected to increase the prevalence of gastro-oesophageal reflux disease. Issues that call for attention by Asian gastroenterologists in the management of gastro-oesophageal reflux disease in the geriatric population include functional changes associated with ageing, such as a lower sensitivity to acid stimulation or pain leading to more atypical presenting symptoms vs. greater severity of disease, common swallowing problems, polypharmacy, and the slower metabolism of the drugs by the kidney. The optimal management of acid-related disorders in the elderly will need to adequately address all these issues.

[1]  K. Torén,et al.  Trends in overweight and obesity from 1985 to 2002 in Göteborg, West Sweden , 2005, International Journal of Obesity.

[2]  D. Graham,et al.  Obesity Is an Independent Risk Factor for GERD Symptoms and Erosive Esophagitis , 2005, The American Journal of Gastroenterology.

[3]  K. Turnheim.  Pharmacokinetic dosage guidelines for elderly subjects , 2005, Expert opinion on drug metabolism & toxicology.

[4]  H. Adachi,et al.  Trends in Nutritional Intake and Serum Cholesterol Levels over 40 Years in Tanushimaru, Japanese Men , 2005, Journal of epidemiology.

[5]  C. Ahn,et al.  Prevalence of obesity in Korea , 2005, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[6]  J. Newton,et al.  Changes in upper gastrointestinal physiology with age , 2004, Mechanisms of Ageing and Development.

[7]  D. Yadav,et al.  Gastrostomy, esophagitis, and gastrointestinal bleeding in older adults. , 2004, Journal of the American Medical Directors Association.

[8]  Hiroshi Shimokata,et al.  Prevention of Gastroesophageal Reflux Using an Application of Half‐Solid Nutrients in Patients with Percutaneous Endoscopic Gastrostomy Feeding , 2004, Journal of the American Geriatrics Society.

[9]  H. Redmond,et al.  Nasogastric intubation causes gastroesophageal reflux in patients undergoing elective laparotomy. , 2001, Surgery.

[10]  E. El-Omar,et al.  Helicobacter pylori gastritis and gastric physiology. , 2000, Gastroenterology clinics of North America.

[11]  H. Garewal,et al.  Symptom severity and oesophageal chemosensitivity to acid in older and young patients with gastro-oesophageal reflux. , 2000, Age and ageing.

[12]  O. Kawamura,et al.  Helicobacter pylori infection correlates with severity of reflux esophagitis: with manometry findings , 1999, Journal of Gastroenterology.

[13]  T. Akamatsu,et al.  Changes in seroepidemiological pattern of Helicobacter pylori and hepatitis A virus over the last 20 years in Japan , 1999, American Journal of Gastroenterology.

[14]  Y. Kinoshita,et al.  Relationship between severity and symptoms of reflux oesophagitis in elderly patients in Japan , 1998, Journal of gastroenterology and hepatology.

[15]  K. Balan,et al.  Gastroesophageal reflux in patients fed by percutaneous endoscopic gastrostomy (PEG) : Detection by a simple scintigraphic method , 1998 .

[16]  H T Hatoum,et al.  Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis. A prospective observational cohort study. , 1996, Archives of internal medicine.

[17]  R. Johnsen,et al.  Non-ulcer dyspepsia and peptic ulcer: the distribution in a population and their relation to risk factors. , 1996, Gut.

[18]  A. Blower,et al.  Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. , 1987, Gut.

[19]  A. Pilotto.  Aging and upper gastrointestinal disorders. , 2004, Best practice & research. Clinical gastroenterology.

[20]  V. Stanghellini.  Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). , 1999, Scandinavian journal of gastroenterology. Supplement.