Synthesis and insecticidal activities of novel spin‐labeled derivatives of camptothecin

Continuing our search for natural product based compounds for the control of Brontispa longissima larvae, eight spin-labeled camptothecin derivatives 7a–h and the intermediate 2 were first tested for their insecticidal activities against fifth-instar larvae of Brontispa longissima. Among all the tested compounds, especially compounds 7a and 2 showed promising insecticidal activities with the corrected mortality rates of 69.55% and 74.07% against fifth-instar larvae of B. longissima, respectively. The different insecticidal activity ranges of these compounds indicated that the variation of the structures of l-amino acids in these compounds markedly affected the activity profiles of this compound class, and some important SAR information has been revealed from it. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 22:687–691, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20734

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