Investigation of MR image distortion for radiotherapy treatment planning of prostate cancer

MR imaging based treatment planning for radiotherapy of prostate cancer is limited due to MR imaging system related geometrical distortions, especially for patients with large body sizes. On our 0.23 T open scanner equipped with the gradient distortion correction (GDC) software, the residual image distortions after the GDC were <5 mm within the central 36 cm x 36 cm area for a standard 48 cm field of view (FOV). In order to use MR imaging alone for treatment planning the effect of residual MR distortions on external patient contour determination, especially for the peripheral regions outside the 36 cm x 36 cm area, must be investigated and corrected. In this work, we performed phantom measurements to quantify MR system related residual geometric distortions after the GDC and the effective FOV. Our results show that for patients with larger lateral dimensions (>36 cm), the differences in patient external contours between distortion-free CT images and GDC-corrected MR images were 1-2 cm because of the combination of greater gradient distortion and loss of field homogeneity away from the isocentre and the uncertainties in patient setup during CT and MRI scans. The measured distortion maps were used to perform point-by-point corrections for patients with large dimensions inside the effective FOV. Using the point-by-point method, the geometrical distortion after the GDC were reduced to <3 mm for external contour determination and the effective FOV was expanded from 36 cm to 42 cm.

[1]  M van Herk,et al.  Definition of the prostate in CT and MRI: a multi-observer study. , 1999, International journal of radiation oncology, biology, physics.

[2]  T E Schultheiss,et al.  Dose escalation with 3D conformal treatment: five year outcomes, treatment optimization, and future directions. , 1998, International journal of radiation oncology, biology, physics.

[3]  L Chen,et al.  Dosimetric evaluation of MRI-based treatment planning for prostate cancer , 2004, Physics in medicine and biology.

[4]  E Bellon,et al.  The contribution of magnetic resonance imaging to the three-dimensional treatment planning of localized prostate cancer. , 1999, International journal of radiation oncology, biology, physics.

[5]  G. Marchal,et al.  On the problem of geometric distortion in magnetic resonance images for stereotactic neurosurgery. , 1994, Magnetic resonance imaging.

[6]  Richard Pötter,et al.  Aspects of MR Image Distortions in Radiotherapy Treatment Planning , 2001, Strahlentherapie und Onkologie.

[7]  G Starkschall,et al.  Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[8]  J. Michael Fitzpatrick,et al.  Geometrical image transformation to compensate for MRI distortions , 1990, Medical Imaging: Image Processing.

[9]  G. Hanks Progress in 3D conformal radiation treatment of prostate cancer. , 1999, Acta oncologica.

[10]  Alan Pollack,et al.  MRI-based treatment planning for radiotherapy: dosimetric verification for prostate IMRT. , 2004, International journal of radiation oncology, biology, physics.

[11]  A Pollack,et al.  Prostate cancer treatment with radiotherapy: maturing methods that minimize morbidity. , 1999, Seminars in oncology.

[12]  E Kanal,et al.  A comparison between magnetic resonance imaging and computed tomography for stereotactic coordinate determination. , 1992, Neurosurgery.

[13]  Steve Webb,et al.  Radiotherapy treatment planning of prostate cancer using magnetic resonance imaging alone. , 2003, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[14]  Benjamin Movsas,et al.  MRI simulation: effect of gradient distortions on three-dimensional prostate cancer plans. , 2002, International journal of radiation oncology, biology, physics.

[15]  A W Beavis,et al.  Radiotherapy treatment planning of brain tumours using MRI alone. , 1998, The British journal of radiology.

[16]  H. Hricak,et al.  Prostate volumes defined by magnetic resonance imaging and computerized tomographic scans for three-dimensional conformal radiotherapy. , 1996, International journal of radiation oncology, biology, physics.

[17]  L. Schad,et al.  Three dimensional image correlation of CT, MR, and PET studies in radiotherapy treatment planning of brain tumors. , 1987, Journal of computer assisted tomography.

[18]  William R. Fair,et al.  DOSE ESCALATION WITH THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY AFFECTS THE OUTCOME IN PROSTATE CANCER , 1998 .

[19]  Wan-Yuo Guo,et al.  Invited. Application of MR in stereotactic radiosurgery , 1998 .

[20]  S Napel,et al.  Quantifying MRI geometric distortion in tissue , 1994, Magnetic resonance in medicine.