Improved growth performance by type 2 porcine reproductive and respiratory syndrome virus (PRRSV)-based modified live vaccine in a herd with concurrent circulation of type 1 and type 2 PRRSV

The objective of this study was to evaluate type 2 porcine reproductive and respiratory syndrome virus (PRRSV)-based modified live vaccine in a herd with concurrent circulation of type 1 and type 2 PRRSV. Type 2 PRRSV-based modified live vaccine improved average daily gain by 48.24 grams/pig/day (631.17 grams/pig/day in the vaccinated group vs 582.93 grams/pig/day in the unvaccinated group; P < 0.05). Pathological examination indicated that the vaccination effectively reduced microscopic lung lesions compared with the control animals. The protection of this vaccine against type 1 and type 2 PRRSV provides clinical control of co-infection with both genotypes under field conditions.

[1]  Dongyou Liu,et al.  Syndrome Virus Nucleocapsid Protein Porcine Reproductive and Respiratory Carboxy-Terminal Beta-Strand of the Antigenic Importance of the , 2001 .

[2]  C. Chae,et al.  Nucleotide sequence analysis of Vietnamese highly pathogenic porcine reproductive and respiratory syndrome virus from 2013 to 2014 based on the NSP2 and ORF5 coding regions , 2015, Archives of Virology.

[3]  C. Chae,et al.  Cross-protection of a new type 2 porcine reproductive and respiratory syndrome virus (PRRSV) modified live vaccine (Fostera PRRS) against heterologous type 1 PRRSV challenge in growing pigs. , 2015, Veterinary microbiology.

[4]  Su-Jin Park,et al.  Comparison of Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Modified Live Vaccines against Heterologous Type 1 and Type 2 PRRSV Challenge in Growing Pigs , 2015, Clinical and Vaccine Immunology.

[5]  C. Chae,et al.  Evaluation of the efficacy of a new modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Fostera PRRS) against heterologous PRRSV challenge. , 2014, Veterinary microbiology.

[6]  C. Chae,et al.  Comparison of the virulence of European and North American genotypes of porcine reproductive and respiratory syndrome virus in experimentally infected pigs. , 2013, Veterinary journal.

[7]  Trevor Wennblom,et al.  Molecular epidemiology of PRRSV: a phylogenetic perspective. , 2010, Virus research.

[8]  K. Yoon,et al.  Molecular characterization of recent Korean porcine reproductive and respiratory syndrome (PRRS) viruses and comparison to other Asian PRRS viruses. , 2006, Veterinary microbiology.

[9]  F. Osorio,et al.  Role of neutralizing antibodies in PRRSV protective immunity. , 2004, Veterinary immunology and immunopathology.

[10]  M. Torremorell,et al.  Detection of U.S., Lelystad, and European-Like Porcine Reproductive and Respiratory Syndrome Viruses and Relative Quantitation in Boar Semen and Serum Samples by Real-Time PCR , 2004, Journal of Clinical Microbiology.

[11]  P. Halbur,et al.  Comparison of the Antigen Distribution of Two US Porcine Reproductive and Respiratory Syndrome Virus Isolates with that of the Lelystad Virus , 1996 .

[12]  P. Halbur,et al.  Comparison of the Pathogenicity of Two US Porcine Reproductive and Respiratory Syndrome Virus Isolates with that of the Lelystad Virus , 1995, Veterinary pathology.