Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function

[1]  Q. Anstee,et al.  A researcher's guide to preclinical mouse NASH models. , 2022, Nature metabolism.

[2]  D. Vertommen,et al.  The intra-mitochondrial O-GlcNAcylation system rapidly modulates OXPHOS function and ROS release in the heart , 2022, Communications Biology.

[3]  C. Hoppel,et al.  Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass , 2021, Scientific Reports.

[4]  Jie-Li Hu,et al.  O-GlcNAc modified-TIP60/KAT5 is required for PCK1 deficiency-induced HCC metastasis , 2021, Oncogene.

[5]  D. Guallar,et al.  A Simple, Rapid, and Cost-Effective Method for Loss-of-Function Assays in Pluripotent Cells. , 2021, Methods in molecular biology.

[6]  Liteng Lin,et al.  Sublethal heat stress-induced O-GlcNAcylation coordinates the Warburg effect to promote hepatocellular carcinoma recurrence and metastasis after thermal ablation. , 2021, Cancer letters.

[7]  M. Roden,et al.  The complex link between NAFLD and type 2 diabetes mellitus — mechanisms and treatments , 2021, Nature Reviews Gastroenterology & Hepatology.

[8]  Jennifer M Aldridge Whitehead,et al.  Prospective evaluation of the prevalence of non-alcoholic fatty liver disease and steatohepatitis in a large middle-aged US cohort. , 2021, Journal of hepatology.

[9]  M. Mcphail,et al.  Mitochondrial dysfunction as a mechanistic biomarker in patients with Non-Alcoholic fatty liver disease (NAFLD). , 2020, Mitochondrion.

[10]  Shelly C. Lu,et al.  Metabolic Landscape of the Mouse Liver by Quantitative 31P Nuclear Magnetic Resonance Analysis of the Phosphorome , 2020, Hepatology.

[11]  H. Liu,et al.  O-GlcNAcylation of SIX1 enhances its stability and promotes Hepatocellular Carcinoma Proliferation , 2020, Theranostics.

[12]  R. Meex,et al.  Mitochondrial Dysfunction is a Key Pathway that Links Saturated Fat Intake to the Development and Progression of NAFLD , 2020, Molecular nutrition & food research.

[13]  T. Lefebvre,et al.  Editorial: O-GlcNAcylation: Expanding the Frontiers , 2019, Front. Endocrinol..

[14]  D. Häussinger,et al.  O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy. , 2019, Journal of hepatology.

[15]  K. Cusi,et al.  From NASH to diabetes and from diabetes to NASH: Mechanisms and treatment options , 2019, JHEP reports.

[16]  Q. Gao,et al.  O‐GlcNAc transferase activates stem‐like cell potential in hepatocarcinoma through O‐GlcNAcylation of eukaryotic initiation factor 4E , 2019, Journal of cellular and molecular medicine.

[17]  Jun Yu,et al.  O-GlcNAc transferase suppresses necroptosis and liver fibrosis , 2019, bioRxiv.

[18]  Xiaoyong Yang,et al.  O-GlcNAc as an Integrator of Signaling Pathways , 2018, Front. Endocrinol..

[19]  X. Zhang,et al.  High glucose stimulates proliferative capacity of liver cancer cells possibly via O‐GlcNAcylation‐dependent transcriptional regulation of GJC1 , 2018, Journal of cellular physiology.

[20]  Fenglin Liu,et al.  O-GlcNAcylation of RACK1 promotes hepatocellular carcinogenesis. , 2018, Journal of hepatology.

[21]  M. Masouminia,et al.  Alcoholic hepatitis versus non-alcoholic steatohepatitis: Levels of expression of some proteins involved in tumorigenesis. , 2018, Experimental and molecular pathology.

[22]  J. Banales,et al.  O-GlcNAcylation: Undesired tripmate but an opportunity for treatment in NAFLD-HCC. , 2017, Journal of hepatology.

[23]  Jun Yu,et al.  O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress. , 2017, Journal of hepatology.

[24]  G. Shulman,et al.  Regulation of hepatic glucose metabolism in health and disease , 2017, Nature Reviews Endocrinology.

[25]  Xiaoyong Yang,et al.  Protein O-GlcNAcylation: emerging mechanisms and functions , 2017, Nature Reviews Molecular Cell Biology.

[26]  N. Zachara,et al.  Stress-induced O-GlcNAcylation: an adaptive process of injured cells. , 2017, Biochemical Society transactions.

[27]  G. Hart,et al.  Roles of O-GlcNAc in chronic diseases of aging. , 2016, Molecular aspects of medicine.

[28]  L. Henry,et al.  Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes , 2016, Hepatology.

[29]  R. Huganir,et al.  The nutrient sensor OGT in PVN neurons regulates feeding , 2016, Science.

[30]  Damien Y. Duveau,et al.  A small molecule that inhibits OGT activity in cells. , 2015, ACS chemical biology.

[31]  T. Issad,et al.  O‐GlcNAcylation of FoxO1 in pancreatic β cells promotes Akt inhibition through an IGFBP1‐mediated autocrine mechanism , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  D. Serra,et al.  Mitochondrial fatty acid oxidation in obesity. , 2013, Antioxidants & redox signaling.

[33]  G. Hart,et al.  Regulation of Insulin Receptor Substrate 1 (IRS-1)/AKT Kinase-mediated Insulin Signaling by O-Linked β-N-Acetylglucosamine in 3T3-L1 Adipocytes* , 2009, The Journal of Biological Chemistry.

[34]  W. V. So,et al.  Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance , 2008, Nature.

[35]  Rohit Kohli,et al.  Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[36]  O. Cummings,et al.  Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.

[37]  R. Karim,et al.  NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome , 2002, Hepatology.

[38]  G. Hart,et al.  The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[39]  C. Drevon,et al.  Eicosapentaenoic acid inhibits synthesis and secretion of triacylglycerols by cultured rat hepatocytes. , 1986, Biochimica et biophysica acta.

[40]  M. Horsch,et al.  N-acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of beta-N-acetylglucosaminidase. , 1991, European journal of biochemistry.