Antihemophilic factor 8 in hemophilia. Use of concentrates to permit major surgery.

Seven surgical procedures were successfully performed on five patients suffering from classic hemophilia. Hemostasis was maintained by the use of three factor VIII concentrates: cryoprecipitate, American National Red Cross high-purity concentrate, and a lyophilized glycine-precipitated fraction. Significant hemorrhage occurred twice, in each instance when the patient's factor VIII levels fell below 20% of normal. The availability of satisfactory concentrates of factor VIII permits consideration of elective surgical procedures in the hemophiliac. It should be emphasized, however, that such operations should be undertaken only if the indications are unequivocal and the necessary clinical and laboratory facilities are available.

[1]  I. Nilsson,et al.  Treatment of hemophilia A with human antihemophilic globulin. , 2009, Acta medica Scandinavica.

[2]  E. Shanbrom,et al.  Experimental prophylaxis of severe hemophilia with a factor VIII concentrate. , 1969, JAMA.

[3]  E. Bowie,et al.  Disappearance Rates of Coagulation Factors: Transfusion Studies in Factor‐Deficient Patients , 1967, Transfusion.

[4]  C. Abildgaard,et al.  Treatment of hemophilia with glycine-precipitated factor 8. , 1966, The New England journal of medicine.

[5]  V. Marder,et al.  Major surgery in classic hemophilia using fraction I: Experience in twelve operations and review of the literature , 1966 .

[6]  J. Pool,et al.  Production of high-potency concentrates of antihemophilic globulin in a closed-bag system. , 1965, The New England journal of medicine.

[7]  H. Roberts,et al.  CLINICAL USE OF A NEW GLYCINE‐PRECIPITATED ANTIHEMOPHILIC FRACTION , 1965, The American journal of the medical sciences.

[8]  K. Brinkhous,et al.  Purification of Antihemophilic Factor (Factor VIII) by Amino Acid Precipitation* , 1964, Thrombosis and Haemostasis.

[9]  R. R. Proctor,et al.  The partial thromboplastin time with kaolin. A simple screening test for first stage plasma clotting factor deficiencies. , 1961, American journal of clinical pathology.

[10]  A. Pavlovsky,et al.  The Use of Factor VIII Freed from Fibrinogen in the Treatment of Haemophilia Patients , 1961, British journal of haematology.

[11]  A. Silverstein.  Intracranial bleeding in hemophilia. , 1960, Transactions of the American Neurological Association.

[12]  M. B. Coventry,et al.  Survival of patient with hemophilia and fracture of femur. , 1959, The Journal of bone and joint surgery. American volume.

[13]  E. Bowie,et al.  The diagnosis of bleeding disorders , 1969 .

[14]  O. Ratnoff.  Treatment of hemorrhagic disorders , 1968 .

[15]  S. Puszkin,et al.  Purification of antihemophilic factor (AHF) for clinical and experimental use. , 1967, Thrombosis et diathesis haemorrhagica. Supplementum.

[16]  R. Biggs,et al.  Treatment of haemophilia and other coagulation disorders , 1966 .