Drug Users’ Willingness to Encourage Social, Sexual, and Drug Network Members to Receive an HIV Vaccine: A Social Network Analysis

This study examined feasibility of peer-based promotion of HIV vaccination and dyadic correlates to vaccine encouragement in risk- and non-risk networks of drug users (n = 433) in the US. Data were collected on HIV vaccine attitudes, risk compensation intentions, likelihood of encouraging vaccination, and recent (past 6 months) risk (i.e. involving sex and/or injecting drugs) and non-risk (i.e. involving co-usage of noninjected drugs and/or social support) relationships. Willingness to encourage HIV vaccination was reported in 521 and 555 risk- and non-risk relationships, respectively. However, 37 % expressed hesitancy, typically due to fear of side effects or social concerns. Encouragement was often motivated by perceived HIV risk, though 9 % were motivated by risk compensation intentions. In non-risk partnerships, encouragement was associated with drug co-usage, and in risk relationships, with perceived vaccine acceptability and encouragement by the partner. Network-based HIV vaccine promotion may be a successful strategy, but risk compensation intentions should be explored.

[1]  Z. Šidák Rectangular Confidence Regions for the Means of Multivariate Normal Distributions , 1967 .

[2]  D. Kerrigan,et al.  Local understanding of an HIV vaccine and its relationship with HIV-related stigma in the Dominican Republic , 2007, AIDS care.

[3]  Martin Fishbein,et al.  An integrative model for behavioral prediction and its application to health promotion. , 2009 .

[4]  M. G. Fonseca,et al.  Modeling HIV Vaccines in Brazil: Assessing the Impact of a Future HIV Vaccine on Reducing New Infections, Mortality and Number of People Receiving ARV , 2010, PloS one.

[5]  L. Swartz,et al.  Community Members' Perceptions of Enablers and Inhibitors to Participation in HIV Vaccine Trials , 2006 .

[6]  T. Valente,et al.  Using Social Networks to Recruit an HIV Vaccine Preparedness Cohort , 2009, Journal of acquired immune deficiency syndromes.

[7]  Danielle S. Seiden,et al.  HIV vaccine acceptability among women at risk: perceived barriers and facilitators to future HIV vaccine uptake. , 2005, AIDS education and prevention : official publication of the International Society for AIDS Education.

[8]  C. del Rio,et al.  Socioecological influences on community involvement in HIV vaccine research. , 2011, Vaccine.

[9]  Alden S. Klovdahl,et al.  Mapping a social network of heterosexuals at high risk for HIV infection , 1994, AIDS.

[10]  H. Meissner,et al.  Conceptual framework for behavioral and social science in HIV vaccine clinical research. , 2011, Vaccine.

[11]  N. Duan,et al.  Differences in HIV vaccine acceptability between genders , 2008, AIDS care.

[12]  C. Logie,et al.  HIV vaccine acceptability and culturally appropriate dissemination among sexually diverse Aboriginal peoples in Canada , 2012, Global public health.

[13]  Karen M. Kuntz,et al.  The Impact of a Partially Effective HIV Vaccine on a Population of Intravenous Drug Users in Bangkok, Thailand: A Dynamic Model , 2002, Journal of acquired immune deficiency syndromes.

[14]  W. Cunningham,et al.  Future HIV Vaccine Acceptability Among Young Adults in South Africa , 2010, Health education & behavior : the official publication of the Society for Public Health Education.

[15]  R. Remien,et al.  Stigma in the HIV/AIDS epidemic: a review of the literature and recommendations for the way forward , 2008, AIDS.

[16]  Gary L. Kreps,et al.  The Community Liaison Program: a health education pilot program to increase minority awareness of HIV and acceptance of HIV vaccine trials. , 2012, Health education research.

[17]  C. del Rio,et al.  Promoting HIV Vaccine Research in African American Communities: Does the Theory of Reasoned Action Explain Potential Outcomes of Involvement? , 2007, Challenge.

[18]  Prevalence of HIV and risky sexual behaviors among rural drug users: does age matter? , 2012, Annals of epidemiology.

[19]  Kumanan Wilson,et al.  Barriers to participating in an HIV vaccine trial: a systematic review , 2004, AIDS.

[20]  R. Crosby,et al.  Emerging theories in health promotion practice and research , 2002 .

[21]  R. Gulakowski,et al.  Assessing the Attitudes, Knowledge, and Awareness of HIV Vaccine Research Among Adults in the United States , 2005, Journal of acquired immune deficiency syndromes.

[22]  P. Pitisuttithum,et al.  Behavioral and Social Issues Among Volunteers in a Preventive HIV Vaccine Trial in Thailand , 2005, Journal of acquired immune deficiency syndromes.

[23]  D. Swendeman,et al.  Posttrial HIV Vaccine Adoption: Concerns, Motivators, and Intentions Among Persons at Risk For HIV , 2004, Journal of acquired immune deficiency syndromes.

[24]  J. Havens,et al.  Network Structure and the Risk for HIV Transmission Among Rural Drug Users , 2013, AIDS and Behavior.

[25]  J. Stover,et al.  The impact of an AIDS vaccine in developing countries: a new model and initial results. , 2007, Health affairs.

[26]  P. Newman,et al.  Preventive HIV vaccine acceptability and behavioral risk compensation among high-risk men who have sex with men and transgenders in Thailand. , 2010, Vaccine.

[27]  Carl A. Kallgren,et al.  A focus theory of normative conduct: Recycling the concept of norms to reduce littering in public places. , 1990 .

[28]  J. Havens,et al.  Transition from first illicit drug use to first injection drug use among rural Appalachian drug users: a cross-sectional comparison and retrospective survival analysis. , 2012, Addiction.

[29]  C. Logie,et al.  HIV vaccine acceptability: a systematic review and meta-analysis , 2010, AIDS.

[30]  M. Quayle,et al.  Local Knowledge and Experiences of Vaccination: Implications for HIV-Preventive Vaccine Trials in South Africa , 2007, Health education & behavior : the official publication of the Society for Public Health Education.

[31]  N. Duan,et al.  Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES). , 2009, Health services research.

[32]  R. Rothenberg,et al.  Sociometric risk networks and risk for HIV infection. , 1997, American journal of public health.

[33]  S Q Muth,et al.  Social networks in disease transmission: the Colorado Springs Study. , 1995, NIDA research monograph.

[34]  D. Owens,et al.  The potential impact of an HIV vaccine with rapidly waning protection on the epidemic in Southern Africa: examining the RV144 trial results. , 2011, Vaccine.

[35]  N. Duan,et al.  HIV risk and prevention in a post-vaccine context. , 2004, Vaccine.

[36]  D. Owens,et al.  Predicting the Impact of a Partially Effective HIV Vaccine and Subsequent Risk Behavior Change on the Heterosexual HIV Epidemic in Low- and Middle-Income Countries: A South African Example , 2007, Journal of acquired immune deficiency syndromes.

[37]  P. Newman,et al.  A social vaccine? Social and structural contexts of HIV vaccine acceptability among most-at-risk populations in Thailand , 2012, Global public health.

[38]  J. Havens,et al.  Individual and network factors associated with prevalent hepatitis C infection among rural Appalachian injection drug users. , 2013, American journal of public health.

[39]  C. Logie,et al.  "Speaking the dialect": understanding public discourse in the aftermath of an HIV vaccine trial shutdown. , 2011, American journal of public health.

[40]  Ronald H Gray,et al.  Stochastic simulation of the impact of antiretroviral therapy and HIV vaccines on HIV transmission; Rakai, Uganda , 2003, AIDS.

[41]  J. Tappero,et al.  Lack of increased HIV risk behavior among injection drug users participating in the AIDSVAX®B/E HIV vaccine trial in Bangkok, Thailand , 2004, AIDS.