Non-linear robust identification using evolutionary algorithms: Application to a biomedical process

This work describes a new methodology for robust identification (RI), meaning the identification of the parameters of a model and the characterization of uncertainties. The alternative proposed handles non-linear models and can take into account the different properties demanded by the model. The indicator that leads the identification process is the identification error (IE), that is, the difference between experimental data and model response. In particular, the methodology obtains the feasible parameter set (FPS, set of parameter values which satisfy a bounded IE) and a nominal model in a non-linear identification problem. To impose different properties on the model, several norms of the IE are used and bounded simultaneously. This improves the model quality, but increases the problem complexity. The methodology proposes that the RI problem is transformed into a multimodal optimization problem with an infinite number of global minima which constitute the FPS. For the optimization task, a special genetic algorithm (@e-GA), inspired by Multiobjective Evolutionary Algorithms, is presented. This algorithm characterizes the FPS by means of a discrete set of models well distributed along the FPS. Finally, an application for a biomedical model which shows the blockage that a given drug produces on the ionic currents of a cardiac cell is presented to illustrate the methodology.