Low gas permeable and non-absorbent rubbery OSTE+ for pneumatic microvalves

In this paper we introduce a new polymer for use in microfluidic applications, based on the off-stoichiometric thiol-ene-epoxy (OSTE+) polymer system, but with rubbery properties. We characterize and benchmark the new polymer against PDMS. We demonstrate that Rubbery OSTE+: has more than 90% lower permeability to gases compared to PDMS, has little to no absorption of dissolved molecules, can be layer bonded in room temperature without the need for adhesives or plasma treatment, can be structured by standard micro-molding manufacturing, and shows similar performance as PDMS for pneumatic microvalves, albeit allowing handling of larger pressure.

[1]  Bruce K. Gale,et al.  Bubble inclusion and removal using PDMS membrane-based gas permeation for applications in pumping, valving and mixing in microfluidic devices , 2009 .

[2]  Laurent Francis,et al.  SUPERIOR DRY BONDING OF OFF-STOICHIOMETRY THIOL-ENEEPOXY (OSTE(+)) POLYMERS FOR HETEROGENEOUS MATERIALLABS-ON-CHIP , 2012 .

[3]  Niklas Sandström,et al.  RAPID FABRICATION OF OSTE+ MICROFLUIDIC DEVICES WITH LITHOGRAPHICALLY DEFINED HYDROPHOBIC/ HYDROPHILIC PATTERNS AND BIOCOMPATIBLE CHIP SEALING , 2013 .

[4]  Wouter van der Wijngaart,et al.  Beyond PDMS: off-stoichiometry thiol-ene (OSTE) based soft lithography for rapid prototyping of microfluidic devices. , 2011, Lab on a chip.

[5]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[6]  Paolo Bettotti,et al.  Dry adhesive bonding of nanoporous inorganic membranes to microfluidic devices using the OSTE(+) dual-cure polymer , 2013 .

[7]  T. Haraldsson,et al.  Ligation-based mutation detection and RCA in surface un-modified OSTE+ polymer microfluidic chambers , 2013, 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII).

[8]  G. Stemme,et al.  Robust microdevice manufacturing by direct lithography and adhesive-free bonding of off-stoichiometry thiol-ene-epoxy (OSTE+) polymer , 2013, 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII).