Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers.

Commercial preparations of fire retardant brominated diphenyl ethers were tested along with bis (p-bromophenyl) ether and diphenyl ether for their ability to alter xenobiotic metabolism. The materials, 0.1 mmol/kg/day, were administered p.o. to male rats for 14 days. Pentabromodiphenyl and octabromodiphenyl ether preparations increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification, p-nitroanisole demethylation, NADPH-cytochrome c reductase, cytochrome P-450, liver weight, UDP-glucuronyltransferase and benzo[a]pyrene hydroxylase. Diphenyl ether increased only EPN detoxification and decabromodiphenyl ether only liver weight. Bis(p-bromophenyl) ether increased liver weight, cytochrome c reductase and cytochrome P-450. The data indicate that these materials are inducers of xenobiotic metabolism with activity dependent upon degree of bromination.

[1]  F. N. David,et al.  Principles and procedures of statistics. , 1961 .

[2]  K. L. Khanna,et al.  Polychlorinated biphenyl-induced alteration of biologic parameters in the rat. , 1974, Toxicology and applied pharmacology.

[3]  G. Carlson.  HALOGENATED BENZENES, EFFECT ON XENOBIOTIC METABOLISM AND THE TOXICITY OF OTHER CHEMICALS * , 1977, Annals of the New York Academy of Sciences.

[4]  D. Bickers,et al.  Polychlorinated biphenyls: comparative effects of high and low chlorine containing Aroclors on hepatic mixed function oxidase. , 1972, Research communications in chemical pathology and pharmacology.

[5]  E. Glover,et al.  Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene. , 1974, Molecular pharmacology.

[6]  D. Nebert,et al.  Substrate-inducible microsomal aryl hydroxylase in mammalian cell culture. I. Assay and properties of induced enzyme. , 1968, The Journal of biological chemistry.

[7]  D. Bickers,et al.  Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[8]  J. Goldstein,et al.  Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448. , 1977, Chemico-biological interactions.

[9]  K. Netter,et al.  The induction of hepatic microsomal metabolism in rats following acute administration of a mixture of polybrominated biphenyls. , 1976, Toxicology and applied pharmacology.

[10]  D. Ecobichon,et al.  The influence of pure polychlorinated biphenyl compounds on hepatic function in the rat. , 1974, Toxicology and applied pharmacology.

[11]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[12]  G. Carlson.  Protection against carbon tetrachloride-induced hepatotoxicity by pretreatment with methylmercury hydroxide. , 1975, Toxicology.

[13]  S. Kawano,et al.  Polychlorinated dibenzofurans--potent inducers of rat hepatic drug-metabolizing enzymes. , 1978, Japanese journal of pharmacology.

[14]  K. P. Dubois,et al.  Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats , 1966 .

[15]  G. Lucier,et al.  Microsomal rat liver UDP glucuronyltransferase: effects of piperonyl butoxide and other factors on enzyme activity. , 1971, Archives of biochemistry and biophysics.

[16]  G. Carlson,et al.  Effect of chlorinated benzenes on the metabolism of foreign organic compounds. , 1976, Toxicology and applied pharmacology.

[17]  V. J. Decarlo.  STUDIES ON BROMINATED CHEMICALS IN THE ENVIRONMENT , 1979, Annals of the New York Academy of Sciences.