In this study, high-performance organic light-emitting diodes (OLEDs) with a buffer layer of polytetrafluoroethylene (Teflon) are demonstrated. Compared with copper phthalocyanine (CuPc), a conventional buffer layer, Teflon shows a lower absorption in the wavelength from 200nm to 800nm. OLEDs with a Teflon layer and a CuPc buffer layer were fabricated under the same conditions, and their performances were compared. The results indicate that the OLEDs with a 1.5-nm-thick Teflon buffer layer had a markedly enhanced performance with an efficiency of 9.0cd/A at a current density of 100mA/cm2, while those with a 30-nm-thick CuPc buffer layer only showed an efficiency of 6.4cd/A at the same current density.