Response: too much BCR-ABL to live on, but too little BCR-ABL to die on?

The mechanistic understanding of persistence of leukemic stem cells during tyrosine kinase inhibitor therapy is an important unmet prerequisite for targeting residual CML and eradicating the disease. Unfortunately, the rarity of BCR-ABL–positive cells during major and complete molecular remission

[1]  F. Guilhot,et al.  BCR-ABL expression in leukemic progenitors and primitive stem cells of patients with chronic myeloid leukemia. , 2012, Blood.

[2]  A. Neubauer,et al.  Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib. , 2012, Blood.

[3]  R. Bhatia,et al.  Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment. , 2011, Blood.

[4]  A. Bennaceur-Griscelli,et al.  Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease. , 2011, Blood.

[5]  B. Druker,et al.  Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity. , 2011, The Journal of clinical investigation.

[6]  Youngho Seo,et al.  Selective activation of p53-mediated tumour suppression in high-grade tumours , 2010, Nature.

[7]  Philippe Rousselot,et al.  Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. , 2010, The Lancet. Oncology.

[8]  G. Evan,et al.  Distinct thresholds govern Myc's biological output in vivo. , 2008, Cancer cell.

[9]  M. Deininger,et al.  Can we afford to let sleeping dogs lie? , 2005, Blood.

[10]  X. H. Wang,et al.  Variable transcription of BCR-ABL by Ph+ cells arising from hematopoietic progenitors in chronic myeloid leukemia. , 1994, Blood.

[11]  B. Zehnbauer,et al.  BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia. , 1993, Blood.