A Framework for Multiproduct Batch Plant Design with Environmental Consideration: Application to Protein Production

Abstract This paper presents a Discrete-Event Simulation (DES) model coupled with simple unit operations models for the solution of the design of multiproduct batch plants. The example of a protein production process serves as an illustration to show the effectiveness of the approach. The results obtained show that a plant configuration can be easily improved, only by changing the campaign policy or the storage strategy for instance. The major interest of the approach is that the use of local models for unit operations will allow the computation of an environmental index in combination with an economical indicator