PICK1 modulates glycolysis and angiogenesis of hypoxic endothelial cells by regulating iron homeostasis.

[1]  Zhi Luo,et al.  Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway , 2022, Cellular and Molecular Life Sciences.

[2]  V. B. Marques,et al.  Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models. , 2022, Biochimica et biophysica acta. General subjects.

[3]  B. Brodin,et al.  Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers , 2022, Fluids and barriers of the CNS.

[4]  Yuchuan Peng,et al.  FSC231 alleviates paclitaxel‐induced neuralgia by inhibiting the interactions between PICK1 and GluA2 and activates GSK‐3β and ERK1/2 , 2021, Brain and behavior.

[5]  M. Zhang,et al.  miR-615-3p promotes the epithelial-mesenchymal transition and metastasis of breast cancer by targeting PICK1/TGFBRI axis , 2020, Journal of experimental & clinical cancer research : CR.

[6]  En-Sheng Ji,et al.  Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia. , 2020, Life sciences.

[7]  Yanmin Zhang,et al.  Inhibitory effect of taspine derivative TAD1822-7 on tumor cell growth and angiogenesis via suppression of EphrinB2 and related signaling pathways , 2019, Acta pharmaceutica.

[8]  Atique U. Ahmed,et al.  HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma , 2019, Cell reports.

[9]  En-Sheng Ji,et al.  Hydrogen Gas Alleviates Chronic Intermittent Hypoxia-Induced Renal Injury through Reducing Iron Overload , 2019, Molecules.

[10]  P. Carmeliet,et al.  Metabolic Pathways Fueling the Endothelial Cell Drive. , 2019, Annual review of physiology.

[11]  Dan Li,et al.  PICK1 Deficiency Induces Autophagy Dysfunction via Lysosomal Impairment and Amplifies Sepsis-Induced Acute Lung Injury , 2018, Mediators of inflammation.

[12]  Anika Saxena,et al.  PDZscape: a comprehensive PDZ-protein database , 2018, BMC Bioinform..

[13]  Liang Han,et al.  PFKFB3 promotes proliferation, migration and angiogenesis in nasopharyngeal carcinoma , 2017, Journal of Cancer.

[14]  Z. Li,et al.  Atorvastatin protects the proliferative ability of human umbilical vein endothelial cells inhibited by angiotensin II by changing mitochondrial energy metabolism , 2017, International journal of molecular medicine.

[15]  A. Bygrave,et al.  PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 α-appendage and dynamin , 2017, The Journal of cell biology.

[16]  J. Pablos,et al.  Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions , 2017, Scientific Reports.

[17]  Freya J. I. Fowkes,et al.  Peripheral artery disease: epidemiology and global perspectives , 2017, Nature Reviews Cardiology.

[18]  Yin Wang,et al.  Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases , 2016, Neurochemistry International.

[19]  Wenjie Wang,et al.  A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway. , 2016, Oncology reports.

[20]  F. Dai,et al.  Farrerol inhibited angiogenesis through Akt/mTOR, Erk and Jak2/Stat3 signal pathway. , 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[21]  D. Tang,et al.  Ferroptosis: process and function , 2016, Cell Death and Differentiation.

[22]  Y. Yonemitsu,et al.  Therapeutic angiogenesis: recent and future prospects of gene therapy in peripheral artery disease. , 2014, Current gene therapy.

[23]  P. Carmeliet,et al.  Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. , 2014, Cell metabolism.

[24]  Peter Carmeliet,et al.  Role of endothelial cell metabolism in vessel sprouting. , 2013, Cell metabolism.

[25]  E. Hermans,et al.  Protein interacting with C kinase and neurological disorders , 2013, Synapse.

[26]  P. Carmeliet,et al.  Role of PFKFB3-Driven Glycolysis in Vessel Sprouting , 2013, Cell.

[27]  B. Annex,et al.  Therapeutic angiogenesis for critical limb ischaemia , 2013, Nature Reviews Cardiology.

[28]  W. Schaper,et al.  Arteriogenesis versus angiogenesis in peripheral artery disease , 2012, Diabetes/metabolism research and reviews.

[29]  E. Weinberg.  The hazards of iron loading. , 2010, Metallomics : integrated biometal science.

[30]  Harel Weinstein,et al.  Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD , 2009, Proceedings of the National Academy of Sciences.

[31]  R. S. Johnson,et al.  Biology of HIF-1α , 2008, Cell Death and Differentiation.

[32]  J. G. Hanley.  PICK1: a multi-talented modulator of AMPA receptor trafficking. , 2008, Pharmacology & therapeutics.

[33]  Jun Xia,et al.  Structure and Function of PICK1 , 2007, Neurosignals.

[34]  Aleksander S Popel,et al.  A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1α , 2006, Journal of Cell Science.

[35]  G. Semenza,et al.  Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1) , 2005, The Journal of pathology.

[36]  G. Semenza,et al.  Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. , 2005, Blood.

[37]  N. Morioka,et al.  Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice , 2004, Pain.

[38]  Geoffrey C Gurtner,et al.  Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 , 2004, Nature Medicine.

[39]  Christopher J. Schofield,et al.  Oxygen sensing by HIF hydroxylases , 2004, Nature Reviews Molecular Cell Biology.

[40]  J. Caro,et al.  Hypoxic regulation of the 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase gene family (PFKFB‐1–4) expression in vivo , 2003, FEBS letters.

[41]  R. Huganir,et al.  Requirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression , 2003, Science.

[42]  X. Tong,et al.  Iron deficiency can upregulate expression of transferrin receptor at both the mRNA and protein level , 2002, British journal of haematology.

[43]  D. Mottet,et al.  ERK activation upon hypoxia: involvement in HIF‐1 activation , 2000, FEBS letters.

[44]  W. Stoorvogel,et al.  Biochemical analysis of distinct Rab5- and Rab11-positive endosomes along the transferrin pathway. , 1999, Journal of cell science.

[45]  C. Lok,et al.  Identification of a Hypoxia Response Element in the Transferrin Receptor Gene* , 1999, The Journal of Biological Chemistry.

[46]  L. Bianchi,et al.  Transferrin Receptor Induction by Hypoxia , 1999, The Journal of Biological Chemistry.

[47]  Yuichi Makino,et al.  Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway* , 1999, The Journal of Biological Chemistry.

[48]  R. Sakakibara,et al.  Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase. , 1997, Journal of biochemistry.

[49]  M. Zerial,et al.  Rab11 regulates recycling through the pericentriolar recycling endosome , 1996, The Journal of cell biology.

[50]  M. Hentze,et al.  Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J Staudinger,et al.  PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system , 1995, The Journal of cell biology.

[52]  E. Schaftingen,et al.  A kinetic study of pyrophosphate: fructose-6-phosphate phosphotransferase from potato tubers. Application to a microassay of fructose 2,6-bisphosphate. , 1982, European journal of biochemistry.

[53]  A. Ahluwalia,et al.  Critical role of hypoxia sensor--HIF-1α in VEGF gene activation. Implications for angiogenesis and tissue injury healing. , 2012, Current medicinal chemistry.