Acoustic streaming induced elimination of nonspecifically bound proteins from a surface acoustic wave biosensor: Mechanism prediction using fluid-structure interaction models

Biosensors typically operate in liquid media for detection of biomarkers and suffer from fouling resulting from nonspecific binding of protein molecules to the device surface. In the current work, using a coupled field finite element fluid-structure interaction simulation, we have identified that fluid motion induced by high intensity sound waves, such as those propagating in these sensors, can lead to the efficient removal of the nonspecifically bound proteins thereby eliminating sensor fouling. We present a computational analysis of the acoustic-streaming phenomenon induced biofouling elimination by surface acoustic-waves (SAWs) propagating on a lithium niobate piezoelectric crystal. The transient solutions generated from the developed coupled field fluid solid interaction model are utilized to predict trends in acoustic-streaming induced forces for varying design parameters such as voltage intensity, device frequency, fluid viscosity, and density. We utilize these model predictions to compute the vario...

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