Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions.
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M Geyer | B. Peterlin | M. Geyer | O. Fackler | A. Alberts | B M Peterlin | O T Fackler | W Luo | A S Alberts | W. Luo
[1] C. Cheng‐Mayer,et al. Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques , 1996, Current Biology.
[2] R. Treisman,et al. Activation of RhoA and SAPK/JNK signalling pathways by the RhoA‐specific exchange factor mNET1 , 1998, The EMBO journal.
[3] J. Kuriyan,et al. Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement , 1997, Nature.
[4] J. Skowroński,et al. Altered T cell activation and development in transgenic mice expressing the HIV‐1 nef gene. , 1993, The EMBO journal.
[5] R. Treisman,et al. The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF , 1995, Cell.
[6] M. Karin,et al. Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs , 1995, Cell.
[7] C. Cheng‐Mayer,et al. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. , 1994, Immunity.
[8] A. Abo,et al. CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1 , 1996, Current Biology.
[9] J. Garcia,et al. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef , 1991, Nature.
[10] R. Flavell,et al. The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes , 1998, The Journal of experimental medicine.
[11] D. Trono,et al. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis , 1995, Journal of virology.
[12] J. Frost,et al. Differential Effects of PAK1-activating Mutations Reveal Activity-dependent and -independent Effects on Cytoskeletal Regulation* , 1998, The Journal of Biological Chemistry.
[13] M. Foti,et al. Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes , 1998, The EMBO journal.
[14] J. S. Sullivan,et al. Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients , 1995, Science.
[15] B. Chait,et al. Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain , 1996, Cell.
[16] A. Guimond,et al. Nef Harbors a Major Determinant of Pathogenicity for an AIDS-like Disease Induced by HIV-1 in Transgenic Mice , 1998, Cell.
[17] John L. Sullivan,et al. Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection , 1995 .
[18] R. Desrosiers,et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS , 1991, Cell.
[19] C. Cheng‐Mayer,et al. A Conserved Domain and Membrane Targeting of Nef from HIV and SIV Are Required for Association with a Cellular Serine Kinase Activity (*) , 1995, The Journal of Biological Chemistry.
[20] O. Danos,et al. Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell , 1995, Journal of virology.
[21] W. Parks,et al. Human Immunodeficiency Virus Type 1 Genome Activation Induced by Human T-Cell Leukemia Virus Type 1 Tax Protein Is through Cooperation of NF-κB and Tat , 1998, Journal of Virology.
[22] L. Zon,et al. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun , 1994, Nature.
[23] K. Tedford,et al. Vav links antigen-receptor signaling to the actin cytoskeleton. , 1998, Seminars in immunology.
[24] P. Cossart,et al. Interaction of invasive bacteria with host signaling pathways. , 1998, Current opinion in cell biology.
[25] K. Schuebel,et al. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. , 1996, Oncogene.
[26] F. Nappi,et al. gag, vif, and nef Genes Contribute to the Homologous Viral Interference Induced by a Nonproducer Human Immunodeficiency Virus Type 1 (HIV-1) Variant: Identification of Novel HIV-1-Inhibiting Viral Protein Mutants , 1998, Journal of Virology.
[27] R. Perona,et al. Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases* , 1998, The Journal of Biological Chemistry.
[28] M. Way,et al. Viral manipulations of the actin cytoskeleton. , 1997, Trends in microbiology.
[29] G. Aldrovandi,et al. Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity , 1994, Journal of virology.
[30] P. Crespo,et al. The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway , 1995, Cell.
[31] C. Cheng‐Mayer,et al. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. , 1996, Virology.
[32] Mario Stevenson,et al. SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1* , 1997, The Journal of Biological Chemistry.
[33] J. Wu,et al. Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. , 1996, Immunity.
[34] K. Schuebel,et al. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product , 1997, Nature.
[35] D. Cowburn,et al. A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV‐1 Nef protein. , 1995, The EMBO journal.
[36] C. Cheng‐Mayer,et al. Human immunodeficiency virus type 1 Nef associates with a cellular serine kinase in T lymphocytes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[37] A. Hall,et al. Rho GTPases and the actin cytoskeleton. , 1998, Science.
[38] G. Nolan,et al. Host Control of HIV-1 Parasitism in T Cells by the Nuclear Factor of Activated T Cells , 1998, Cell.
[39] D. Richman,et al. The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation. , 1995, Virology.
[40] J. Skowroński,et al. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling , 1997, The EMBO journal.
[41] D. Baltimore,et al. Proline‐rich (PxxP) motifs in HIV‐1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down‐regulation of CD4. , 1995, The EMBO journal.
[42] A. Rice,et al. Tat-Associated Kinase, TAK, Activity Is Regulated by Distinct Mechanisms in Peripheral Blood Lymphocytes and Promonocytic Cell Lines , 1998, Journal of Virology.
[43] R. Treisman,et al. The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c‐fos transcription in response to UV light. , 1996, The EMBO journal.
[44] J. Marsh,et al. Human immunodeficiency virus type 1 Nef associates with a member of the p21-activated kinase family , 1996, Journal of virology.
[45] G. Bokoch,et al. Membrane targeting of p21‐activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells , 1998, The EMBO journal.
[46] M. Greenberg,et al. The SH3 domain‐binding surface and an acidic motif in HIV‐1 Nef regulate trafficking of class I MHC complexes , 1998, The EMBO journal.
[47] S. Arold,et al. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. , 1997, Structure.
[48] M. Greenberg,et al. Co‐localization of HIV‐1 Nef with the AP‐2 adaptor protein complex correlates with Nef‐induced CD4 down‐regulation , 1997, The EMBO journal.
[49] S. Arold,et al. RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. , 1998, Biochemistry.
[50] P. Luciw,et al. Role of the SH3-Ligand Domain of Simian Immunodeficiency Virus Nef in Interaction with Nef-Associated Kinase and Simian AIDS in Rhesus Macaques , 1998, Journal of Virology.
[51] J. Penninger,et al. Vav Regulates Peptide-specific Apoptosis in Thymocytes , 1998, The Journal of experimental medicine.
[52] F. Lemonnier,et al. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein , 1996, Nature Medicine.
[53] Steven G. Deeks,et al. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans , 1999, Nature Medicine.
[54] W C Greene,et al. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef , 1995, Journal of virology.
[55] F. Brodsky,et al. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. , 1998, Immunity.
[56] S. Le Gall,et al. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. , 1998, Immunity.
[57] M. Vihinen,et al. SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase. , 1998, Virology.
[58] S. Bagrodia,et al. Cytoskeletal Reorganization by G Protein-Coupled Receptors Is Dependent on Phosphoinositide 3-Kinase γ, a Rac Guanosine Exchange Factor, and Rac , 1998, Molecular and Cellular Biology.
[59] L. Lim,et al. A Conserved Negative Regulatory Region in αPAK: Inhibition of PAK Kinases Reveals Their Morphological Roles Downstream of Cdc42 and Rac1 , 1998, Molecular and Cellular Biology.
[60] J. Garcia,et al. The association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependent , 1996, Journal of virology.
[61] S. Grzesiek,et al. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase , 1996, Nature Structural Biology.
[62] O. Hobert,et al. Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction. , 1994, The Journal of biological chemistry.
[63] M. Karin,et al. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. , 1998, Immunity.
[64] C. Der,et al. Lck regulates Vav activation of members of the Rho family of GTPases , 1997, Molecular and cellular biology.
[65] K. Schuebel,et al. Phosphorylation‐dependent and constitutive activation of Rho proteins by wild‐type and oncogenic Vav‐2 , 1998, The EMBO journal.
[66] R. Desrosiers,et al. A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation , 1997, Journal of virology.