Genetics of Alcoholism

Recently, the first genome-wide searches for genes predisposing to or protecting against the development of alcohol dependence in humans have been carried out. Genetic studies in animal models of alcohol-related behaviors have also identified candidate chromosomal regions and potential candidate genes that can be tested in human populations.

[1]  C. Robert Cloninger,et al.  Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. , 1981, Archives of general psychiatry.

[2]  H. Pétursson,et al.  A Genetic Linkage Study of the D2 Dopamine Receptor Locus in Heavy Drinking and Alcoholism , 1996, British Journal of Psychiatry.

[3]  J. Long,et al.  A functionally deficient DRD2 variant [Ser311Cys] is not linked to alcoholism and substance abuse. , 1998, Alcohol.

[4]  P. McGuffin,et al.  Platelet monoamine oxidase (MAO) activity: evidence for a single major locus. , 1984, American journal of human genetics.

[5]  K. Neiswanger,et al.  Association and linkage studies of the TAQI A1 allele at the dopamine D2 receptor gene in samples of female and male alcoholics. , 1995, American journal of medical genetics.

[6]  K. Kendler,et al.  Stressful life events and genetic liability to major depression: genetic control of exposure to the environment? , 1997, Psychological Medicine.

[7]  P. Manowitz,et al.  Arylsulfatase A variants in patients with alcoholism. , 1984, Alcoholism, clinical and experimental research.

[8]  C. Robert Cloninger,et al.  Maternal inheritance of alcohol abuse. Cross-fostering analysis of adopted women. , 1981, Archives of general psychiatry.

[9]  H. Neville,et al.  Language processing in men at risk for alcoholism: an event-related potential study. , 1985, Alcohol.

[10]  A. Heath Genetic Influences on Alcoholism Risk: A Review of Adoption and Twin Studies. , 1995 .

[11]  R. Kessler,et al.  A population-based twin study of alcoholism in women. , 1992, JAMA.

[12]  H. Begleiter,et al.  Brain Dysfunction and Alcohol , 1983 .

[13]  C. C. Chen,et al.  Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. , 1999, American journal of human genetics.

[14]  J. Feighner,et al.  Diagnostic criteria for use in psychiatric research. , 1972, Archives of general psychiatry.

[15]  M. Schuckit,et al.  A study of alcoholism in half siblings. , 1972, The American journal of psychiatry.

[16]  N Risch,et al.  The Future of Genetic Studies of Complex Human Diseases , 1996, Science.

[17]  R. Murray,et al.  Current genetic and biological approaches to alcoholism. , 1983, Psychiatric developments.

[18]  D. Botstein,et al.  Construction of a genetic linkage map in man using restriction fragment length polymorphisms. , 1980, American journal of human genetics.

[19]  R. Corsico,et al.  Association of HLA antigens with alcoholic disease. , 1988, Journal of studies on alcohol.

[20]  R. Elston,et al.  Possible linkage between alcoholism and esterase-D. , 1988, Journal of studies on alcohol.

[21]  Ting-kai Li,et al.  Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. , 1994, Alcoholism, clinical and experimental research.

[22]  K. Syndulko,et al.  D2 dopamine receptor TaqI A alleles in medically ill alcoholic and nonalcoholic patients. , 1994, Alcohol and alcoholism.

[23]  C. Wolff,et al.  Distribution of HLA histocompatibility antigens, ABO blood groups and Rh antigens in alcoholic liver disease. , 1979, Gut.

[24]  S. Hodge,et al.  The information contained in multiple sibling pairs , 1984, Genetic epidemiology.

[25]  K. Kendler,et al.  Boundaries of major depression: an evaluation of DSM-IV criteria. , 1998, The American journal of psychiatry.

[26]  B. Rabin,et al.  Suggestive evidence of genetic linkage between alcoholism and the MNS blood group. , 1988, Alcoholism, clinical and experimental research.

[27]  Daniel L. Koller,et al.  A family-based analysis of the association of the dopamine D2 receptor (DRD2) with alcoholism. , 1998, Alcoholism, clinical and experimental research.

[28]  M. Schuckit FAMILY HISTORY AND HALF‐SIBLING RESEARCH IN ALCOHOLISM * , 1972, Annals of the New York Academy of Sciences.

[29]  J. Rice,et al.  Genome-wide search for genes affecting the risk for alcohol dependence. , 1998, American journal of medical genetics.

[30]  M. Schuckit,et al.  A simultaneous evaluation of multiple markers of ethanol/placebo challenges in sons of alcoholics and controls. , 1988, Archives of general psychiatry.

[31]  H. Begleiter,et al.  Event-related brain potentials in boys at risk for alcoholism. , 1984, Science.

[32]  H J Edenberg,et al.  Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. , 1989, The Journal of clinical investigation.

[33]  D. Crabb,et al.  The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. , 1996, The Journal of clinical investigation.

[34]  J. Long,et al.  Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. , 1998, American journal of medical genetics.

[35]  S. Higuchi Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. , 1994, Alcohol and alcoholism (Oxford, Oxfordshire). Supplement.

[36]  K. Lange,et al.  The affected-pedigree-member method of linkage analysis. , 1988, American journal of human genetics.

[37]  D. W. Goodwin,et al.  Alcoholism and depression in adopted-out daughters of alcoholics. , 1977, Archives of general psychiatry.

[38]  B. Tabakoff,et al.  Differences in platelet enzyme activity between alcoholics and nonalcoholics. , 1988, The New England journal of medicine.

[39]  R. Murray,et al.  Association between variants at the GABAAβ2, GABAAα6 and GABAAγ2 gene cluster and alcohol dependence in a Scottish population , 1999, Molecular Psychiatry.

[40]  R. Kessler,et al.  A twin-family study of alcoholism in women. , 1994, The American journal of psychiatry.

[41]  M. Smith,et al.  Genetics of human alcohol and aldehyde dehydrogenases. , 1986, Advances in human genetics.

[42]  Ting-kai Li,et al.  Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents. , 1998, Critical reviews in neurobiology.

[43]  J Blangero,et al.  Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. II. Alcoholism and event-related potentials. , 1999, American journal of human genetics.

[44]  Christian Lüscher,et al.  G Protein-Coupled Inwardly Rectifying K+ Channels (GIRKs) Mediate Postsynaptic but Not Presynaptic Transmitter Actions in Hippocampal Neurons , 1997, Neuron.

[45]  D. Murphy,et al.  Changes in platelet monoamine oxidase activity during abstinence. , 1981, Journal of studies on alcohol.

[46]  A. Roe The Adult Adjustment of Children of Alcoholic Parents Raised in Foster-Homes , 1944 .

[47]  C. Robert Cloninger,et al.  Etiologic heterogeneity in alcoholism , 1987, Genetic epidemiology.

[48]  R. Murray,et al.  Association Analysis of Sequence Variants of the GABAAα6, β2, and γ2 Gene Cluster and Alcohol Dependence , 1999 .

[49]  J. Haines,et al.  Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11) and DNA polymorphism. , 1988, Genomics.

[50]  J. Nurnberger,et al.  A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. , 1994, Journal of studies on alcohol.

[51]  D. Doniach,et al.  Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease. , 1976, British medical journal.

[52]  C. Robert Cloninger,et al.  Genetic heterogeneity and the classification of alcoholism. , 1988, Advances in alcohol & substance abuse.

[53]  L. Bierut,et al.  Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men , 1997, Psychological Medicine.

[54]  K. Kendler,et al.  Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. , 1999, The American journal of psychiatry.

[55]  H. Eklund,et al.  3 Alcohol Dehydrogenases , 1975 .

[56]  Y. F. Wang,et al.  Polymorphism of ADH and ALDH genes among four ethnic groups in China and effects upon the risk for alcoholism. , 1997, Alcoholism, clinical and experimental research.

[57]  Ting-kai Li,et al.  Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. , 1991, American journal of human genetics.

[58]  R. Fauchet,et al.  HLA antigens in chronic alcoholic pancreatitis. , 2008, Tissue antigens.

[59]  J. P. Martin,et al.  Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? , 1999, Alcohol.

[60]  W J Ewens,et al.  The TDT and other family-based tests for linkage disequilibrium and association. , 1996, American journal of human genetics.

[61]  C. Robert Cloninger,et al.  Replication of the Stockholm Adoption Study of alcoholism. Confirmatory cross-fostering analysis. , 1996, Archives of general psychiatry.

[62]  D. Lykken,et al.  Heterogeneity in the inheritance of alcoholism. A study of male and female twins. , 1991, Archives of general psychiatry.

[63]  R. Young,et al.  D2 dopamine receptor and GABAA receptor β3 subunit genes and alcoholism , 1998, Psychiatry Research.