About Estimating the Limit of Detection by the Signal to Noise Approach

The limit of detection (LOD) is an important figure of merit estimated in validation studies or when reporting the performances of an analytical method. While the very meaning of LOD is clear to anyone, its estimation is still matter of discussion. This explains the plethora of available approaches. However, the most popular are generally the simplest ones. Between these, it is worth mentioning the approach based on the signal to noise (S/N) ratio, included among those suggested by international guidelines such asthe United States Pharmacopeia, the European Pharmacopoeia and others. This contribution attempts evaluating if this approach could be replaced by that based on the standard error of estimate, sy/x.

[1]  G. Scollary,et al.  A statistical overview of standard (IUPAC and ACS) and new procedures for determining the limits of detection and quantification: Application to voltammetric and stripping techniques (Technical Report) , 1997 .

[2]  W. Huber.  Basic calculations about the limit of detection and its optimal determination , 2003 .

[3]  Majid Rezayi,et al.  Limit of detection and limit of quantification development procedures for organochlorine pesticides analysis in water and sediment matrices , 2013, Chemistry Central Journal.

[4]  Barbara Brunetti,et al.  Presenting Analytical Performances of Electrochemical Sensors. Some Suggestions , 2013 .

[5]  Edward Voigtman,et al.  Limits of detection and decision. Part 3 , 2008 .

[6]  Klaus Danzer,et al.  Analytical Chemistry: Theoretical and Metrological Fundamentals , 2006 .

[7]  Lloyd A. Currie,et al.  DETECTION : INTERNATIONAL UPDATE, AND SOME EMERGING DI-LEMMAS INVOLVING CALIBRATION, THE BLANK, AND MULTIPLE DETECTION DECISIONS , 1997 .

[8]  Edward Voigtman.  Limits of detection and decision. Part 2 , 2008 .

[9]  Linfield Brown,et al.  Limit of Detection , 2002 .

[10]  Michael Thompson,et al.  Towards an uncertainty paradigm of detection capability , 2013 .

[11]  B. Brunetti,et al.  About literature information on functional relationships and limits of detection: may authors improve their statements? , 2012, Accreditation and Quality Assurance.

[12]  B. Brunetti,et al.  About estimating the limit of detection of heteroscedastic analytical systems. , 2009, Analytica chimica acta.

[13]  A. McNaught,et al.  Compendium of chemical terminology. IUPAC recommendations , 1997 .

[14]  Edward Voigtman,et al.  Limits of detection and decision. Part 4 , 2008 .

[15]  Eric R. Ziegel,et al.  Statistics and Chemometrics for Analytical Chemistry , 2004, Technometrics.

[16]  James N. Miller,et al.  Basic statistical methods for analytical chemistry. Part I. Statistics of repeated measurements. A review , 1988 .

[17]  K. T. Abraham,et al.  True detection limits in an experimental linearly heteroscedastic system. Part 1 , 2011 .

[18]  Davor Z Antanasijević,et al.  Review: the approaches for estimation of limit of detection for ICP-MS trace analysis of arsenic. , 2012, Talanta.

[19]  Edward Voigtman,et al.  Limits of detection and decision. Part 1 , 2008 .

[20]  R. Filipek,et al.  Comparison of different approaches to the description of the detection limit of ion-selective electrodes , 2010 .

[21]  L. Currie.  Some case studies of skewed (and other ab-normal) data distributions arising in low-level environmental research , 2001, Fresenius' journal of analytical chemistry.

[22]  Ramón Huerta,et al.  Estimation of the limit of detection using information theory measures. , 2014, Analytica chimica acta.

[23]  B. M. Golam Kibria,et al.  Methods for Testing Population Signal-to-Noise Ratio , 2014, Commun. Stat. Simul. Comput..

[24]  L. P. Eksperiandova,et al.  Once again about determination and detection limits , 2010 .

[25]  James N. Miller.  Basic statistical methods for Analytical Chemistry. Part 2. Calibration and regression methods. A review , 1991 .

[26]  Alankar Shrivastava,et al.  Methods for the determination of limit of detection and limit of quantitation of the analytical methods , 2011 .

[27]  E. Voigtman,et al.  Statistical properties of limit of detection test statistics. , 2003, Talanta.