Development and validation of a general approach to predict and quantify the synergism of anti-cancer drugs using experimental design and artificial neural networks.

[1]  L. Ruiz-Azuara,et al.  Casiopeina III-ia induces apoptosis in HCT-15 cells in vitro through caspase-dependent mechanisms and has antitumor effect in vivo , 2008, BioMetals.

[2]  Ericka Stricklin-Parker,et al.  Ann , 2005 .

[3]  Daniel Svozil,et al.  Introduction to multi-layer feed-forward neural networks , 1997 .

[4]  Berenbaum Mc What is synergy? , 1989, Pharmacological reviews.

[5]  P. Lohman,et al.  Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity. , 1984, Cancer research.

[6]  Jadwiga Indulska,et al.  Proceedings of IEEE International Conference on Networks , 1999 .

[7]  T. Chou,et al.  Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. , 2005, European journal of biochemistry.

[8]  Riccardo Leardi,et al.  Experimental design in chemistry: A tutorial. , 2009, Analytica chimica acta.

[9]  C. I. Bliss THE TOXICITY OF POISONS APPLIED JOINTLY1 , 1939 .

[10]  Ting-Chao Chou,et al.  Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies , 2006, Pharmacological Reviews.

[11]  W. Greco,et al.  The search for synergy: a critical review from a response surface perspective. , 1995, Pharmacological reviews.

[12]  T Chou,et al.  Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition. , 1974, Molecular pharmacology.

[13]  A. Eastman,et al.  Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum(II). , 1988, Biochemistry.

[14]  J. Havel,et al.  Laser desorption ionization of red phosphorus clusters and their use for mass calibration in time-of-flight mass spectrometry. , 2009, Rapid communications in mass spectrometry : RCM.

[15]  Deniz Baş,et al.  Modeling and optimization I: Usability of response surface methodology , 2007 .

[16]  J Desmyter,et al.  Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. , 1988, Journal of virological methods.

[17]  Y. Pommier,et al.  Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. , 2002, Cancer research.

[18]  C. Castellano,et al.  Synthesis, structural characterization, formation constants and in vitro cytotoxicity of phenanthroline and imidazolidine-2-thione copper(II) complexes. , 2011, Journal of inorganic biochemistry.

[19]  T. Chou Drug combination studies and their synergy quantification using the Chou-Talalay method. , 2010, Cancer research.

[20]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[21]  Martin A. Riedmiller,et al.  A direct adaptive method for faster backpropagation learning: the RPROP algorithm , 1993, IEEE International Conference on Neural Networks.

[22]  S. D. Jong,et al.  Handbook of Chemometrics and Qualimetrics , 1998 .

[23]  C. Castellano,et al.  Mixed-1,10-phenanthroline-Cu(II) complexes: synthesis, cytotoxic activity versus hematological and solid tumor cells and complex formation equilibria with glutathione. , 2012, Journal of inorganic biochemistry.

[24]  Johanna Smeyers-Verbeke,et al.  Handbook of Chemometrics and Qualimetrics: Part A , 1997 .

[25]  Peter Gluchowski,et al.  F , 1934, The Herodotus Encyclopedia.

[26]  T. Chou,et al.  Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. , 1984, Advances in enzyme regulation.

[27]  I A Basheer,et al.  Artificial neural networks: fundamentals, computing, design, and application. , 2000, Journal of microbiological methods.