Vitamin D deficiency and age at menarche: a prospective study.

BACKGROUND Early menarche is a risk factor for cardiometabolic disease and cancer. Latitude, which influences sun exposure, is inversely related to age at menarche. This association might be related to vitamin D, but to our knowledge it has not been investigated in prospective epidemiologic studies. OBJECTIVE We studied the association between vitamin D status and the occurrence of menarche in a prospective study in girls from Bogota, Colombia. DESIGN We measured plasma 25-hydroxyvitamin D [25(OH)D] concentrations in a random sample of 242 girls (mean ± SD age: 8.8 ± 1.6 y) and followed them for a median of 30 mo. Girls were asked periodically about the occurrence and date of menarche. Baseline 25(OH)D concentrations were categorized as <50 nmol/L (deficient), ≥50 and <75 nmol/L, or ≥75 nmol/L (sufficient). The incidence of menarche was compared between groups by using time-to-event analyses. RESULTS A total of 57% of girls in the vitamin D-deficient group reached menarche during follow-up compared with 23% of girls in the vitamin D-sufficient group (P-trend = 0.0004). The estimated mean (±SE) ages at menarche in the same groups were 11.8 ± 0.2 y and 12.6 ± 0.2 y, respectively (P = 0.0009). After adjustment for baseline age and BMI-for-age z score in a Cox proportional hazards model, the probability of menarche was twice as high in vitamin D-deficient girls than in girls who were vitamin D-sufficient (HR: 2.05; 95% CI: 1.03, 4.07; P = 0.04). Similar results were obtained in girls aged ≥9 y at baseline (HR: 2.39; 95% CI: 1.14, 5.00; P = 0.02). CONCLUSION Vitamin D deficiency is associated with earlier menarche.

[1]  C. Mølgaard,et al.  Estimation of the dietary requirement for vitamin D in healthy adolescent white girls. , 2011, The American journal of clinical nutrition.

[2]  A. Wiley.  Milk Intake and Total Dairy Consumption: Associations with Early Menarche in NHANES 1999-2004 , 2011, PloS one.

[3]  R. Lewis,et al.  25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. , 2010, The Journal of clinical endocrinology and metabolism.

[4]  W. Willett,et al.  Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. , 2010, The American journal of clinical nutrition.

[5]  Christian Gieger,et al.  Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies , 2010, Nature Genetics.

[6]  J. Toppari,et al.  Trends in puberty timing in humans and environmental modifiers , 2010, Molecular and Cellular Endocrinology.

[7]  F. Clavel-Chapelon,et al.  Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition , 2010, International journal of cancer.

[8]  J. Argente,et al.  Increased circulating adiponectin levels and decreased leptin/soluble leptin receptor ratio throughout puberty in female ballet dancers: association with body composition and the delay in puberty. , 2010, European journal of endocrinology.

[9]  R. Jorde,et al.  Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. , 2010, American journal of epidemiology.

[10]  F. Hu,et al.  Age at menarche and risk of type 2 diabetes: results from 2 large prospective cohort studies. , 2010, American journal of epidemiology.

[11]  S. Sharp,et al.  Early age at menarche associated with cardiovascular disease and mortality. , 2009, The Journal of clinical endocrinology and metabolism.

[12]  M. Mora-Plazas,et al.  Provision of a school snack is associated with vitamin B-12 status, linear growth, and morbidity in children from Bogota, Colombia. , 2009, The Journal of nutrition.

[13]  J. Chavarro,et al.  Growing up under generalized violence: an ecological study of homicide rates and secular trends in age at menarche in Colombia, 1940s-1980s. , 2009, Economics and human biology.

[14]  G. Maskarinec,et al.  Association of Leptin, 25-Hydroxyvitamin D, and Parathyroid Hormone in Women , 2009, Nutrition and cancer.

[15]  S. Radovick,et al.  Pubertal Development and Menarche , 2008, Annals of the New York Academy of Sciences.

[16]  R. Sharpe,et al.  Public Health Implications of Altered Puberty Timing , 2008, Pediatrics.

[17]  G. B. Buck Louis,et al.  Environmental Factors and Puberty Timing: Expert Panel Research Needs , 2008, Pediatrics.

[18]  Setting Brazil.  Establishing a standard definition for child overweight and obesity worldwide: international survey. , 2008 .

[19]  M. Onis,et al.  Development of a WHO Growth Reference for School-Aged Children and adolescents/Mise Au Point D'une Reference De Croissance Pour Les Enfants D'age Scolaire et Les Adolescents/ Elaboracion De Valores De Referencia De la OMS Para El Crecimiento De Escolares Y Adolescentes , 2007 .

[20]  M. Holick.  Vitamin D deficiency. , 2007, The New England journal of medicine.

[21]  Joyce M. Lee,et al.  Weight Status in Young Girls and the Onset of Puberty , 2007, Pediatrics.

[22]  R. Wood,et al.  Vitamin D status and the metabolic syndrome. , 2006, Nutrition reviews.

[23]  T. Grivas,et al.  Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes , 2006, Scoliosis.

[24]  C. Cowell,et al.  Growth, bone mass, and vitamin D status of Chinese adolescent girls 3 y after withdrawal of milk supplementation. , 2006, The American journal of clinical nutrition.

[25]  R. Millsap,et al.  Early Puberty and Adolescent Pregnancy: The Influence of Alcohol Use , 2005, Pediatrics.

[26]  E. Demerath,et al.  Heritability of age at menarche in girls from the Fels Longitudinal Study. , 2005, American journal of physical anthropology.

[27]  J. McGrath,et al.  Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain , 2005, Journal of Chemical Neuroanatomy.

[28]  R. Rizzoli,et al.  Interaction between calcium intake and menarcheal age on bone mass gain: an eight-year follow-up study from prepuberty to postmenarche. , 2005, The Journal of clinical endocrinology and metabolism.

[29]  Steven A. Smith,et al.  Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. , 2005, Journal of chemical neuroanatomy.

[30]  J. Toppari,et al.  The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. , 2003, Endocrine reviews.

[31]  L. Birch,et al.  Percent body fat at age 5 predicts earlier pubertal development among girls at age 9. , 2003, Pediatrics.

[32]  H. Itoh,et al.  Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin. , 2000, The Journal of clinical investigation.

[33]  J. Escalada,et al.  Regulation of Gonadal and Somatotropic Axis by Chronic Intraventricular Infusion of Insulin-Like Growth Factor 1 Antibody at the Initiation of Puberty in Male Rats , 1999, Neuroendocrinology.

[34]  B. Zemel,et al.  Evaluation of methodology for nutritional assessment in children: anthropometry, body composition, and energy expenditure. , 1997, Annual review of nutrition.

[35]  S. Radovick,et al.  Regulation of gonadotropin-releasing hormone (GnRH) gene expression by insulin-like growth factor I in a cultured GnRH-expressing neuronal cell line. , 1997, Molecular endocrinology.

[36]  J. Flier,et al.  Leptin accelerates the onset of puberty in normal female mice. , 1997, The Journal of clinical investigation.

[37]  S. Ojeda,et al.  Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. , 1996, Endocrinology.

[38]  W. van Mechelen,et al.  Rapid maturation in adolescence results in greater obesity in adulthood: the Amsterdam Growth and Health Study. , 1996, The American journal of clinical nutrition.

[39]  A. Bonen.  Recreational Exercise Does Not Impair Menstrual Cycles: A Prospective Study , 1992, International journal of sports medicine.

[40]  S. Yuasa,et al.  Age at menarche, age at menopause, height and obesity as risk factors for breast cancer: Associations and interactions in an international case‐control study , 1990, International journal of cancer.

[41]  M. Holick,et al.  Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. , 1988, The Journal of clinical endocrinology and metabolism.