Deriving heart period variability from blood pressure waveforms.

International standards for calculating heart period variability (HPV) from a series of R-wave intervals (R-R) in an electrocardiographic (ECG) recording have been widely accepted. It is possible, and potentially useful in various settings, to use systolic blood pressure waveform intervals to estimate HPV, but the validity of HPV derived from blood pressure (BP) waveforms has not been established. To test the reliability between BP- and ECG-derived HPV indexes, we evaluated data from 234 healthy adults in four studies of HPV reactivity to stress. Study conditions included resting baseline, arithmetic, Stroop test, speech presentation, and orthostatic tilt. Continuous ECG and BP recordings were sampled at a rate of 500 Hz, scored by the same methods, and used to calculate heart rate and time- and frequency-domain measures of HPV. Overall, reliability between the two methods was very high for computing heart rate and HPV indexes. High-frequency HPV indexes were somewhat less reliably computed. In conclusion, in healthy adults, with the use of appropriate methods, BP waveforms can produce reliable indexes of HPV.

[1]  P A Shapiro,et al.  Hostility, Gender, and Cardiac Autonomic Control , 2001, Psychosomatic medicine.

[2]  N Chhina,et al.  Changes in pulse transit time and pulse rate as markers of arousal from sleep in normal subjects. , 1994, Clinical science.

[3]  R. Edelberg,et al.  Comparison of finger plethysmograph to ECG in the measurement of heart rate variability. , 2002, Psychophysiology.

[4]  W. Riley,et al.  Arterial stiffness: a new cardiovascular risk factor? , 1994, American journal of epidemiology.

[5]  J. Blacher,et al.  Stiffness of carotid artery wall material and blood pressure in humans: application to antihypertensive therapy and stroke prevention. , 2000, Stroke.

[6]  M. Turiel,et al.  Power Spectral Analysis of Heart Rate and Arterial Pressure Variabilities as a Marker of Sympatho‐Vagal Interaction in Man and Conscious Dog , 1986, Circulation research.

[7]  J. Strackee,et al.  Comparing Spectra of a Series of Point Events Particularly for Heart Rate Variability Data , 1984, IEEE Transactions on Biomedical Engineering.

[8]  J. Blacher,et al.  Increased Arterial Distensibility in Postmenopausal Hypertensive Women with and Without Hormone Replacement Therapy after Acute Administration of the Ace Inhibitor Moexipril , 1998, Cardiovascular Drugs and Therapy.

[9]  R. González,et al.  Comparison of the heart rate variability parameters obtained from the electrocardiogram and the blood pressure wave. , 1998, Journal of medical engineering & technology.

[10]  Hostility, gender, and cardiac autonomic control. , 1999 .

[11]  Torsten Husén,et al.  A methodological study , 1959 .

[12]  A. Szabo,et al.  The combined effects of orthostatic and mental stress on heart rate, T-wave amplitude, and pulse transit time , 2004, European Journal of Applied Physiology and Occupational Physiology.

[13]  M. Safar,et al.  Peripheral haemodynamic effects of smoking in habitual smokers. A methodological study , 2004, European Journal of Clinical Pharmacology.

[14]  D. Mant.  Prevention , 1994, The Lancet.

[15]  J. Furedy,et al.  Effects of psychological and physiological challenges on heart rate, T-wave amplitude, and pulse-transit time. , 1996, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[16]  D. O'Leary.  Autonomic mechanisms of muscle metaboreflex control of heart rate. , 1993, Journal of applied physiology.

[17]  J. Fleiss.  The design and analysis of clinical experiments , 1987 .

[18]  M. Safar,et al.  Early arterial modifications in young patients with borderline hypertension , 1989, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

[19]  F. Harris.  On the use of windows for harmonic analysis with the discrete Fourier transform , 1978, Proceedings of the IEEE.

[20]  T. Kamarck,et al.  Reliable measures of behaviorally-evoked cardiovascular reactivity from a PC-based test battery: results from student and community samples. , 1992, Psychophysiology.

[21]  A. Malliani,et al.  Heart rate variability. Standards of measurement, physiological interpretation, and clinical use , 1996 .

[22]  G. Breithardt,et al.  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996 .