IgA cold agglutinins recognize Pr and Sa antigens expressed on glycophorins

Three cases of IgAκ cold agglutinins (CAs) were studied. One had anti‐Pr1 specificity, one had anti‐Pra, and one had anti‐Sa. The CAs recognize O‐glycans of glycophorins. The findings supplement previous data on anti‐Pr1 specificities of four IgAκ CAs. Because all IgA kappa CAs described recognize O‐glycans of glycophorins, a close association between the CA IgA isotype and specificities for O‐glycans becomes apparent. It is unlikely, however, that the striking association reflects interrelations between IgA CA structure and specificity, because anti‐Sa specificity and all anti‐Pr subspecificities were originally defined with IgM CAs.

[1]  H. Chaplin,et al.  Life‐threatening, antiglobulin test‐negative, acute autoimmune hemolytic anemia due to a non‐complement‐activating IgG1 kappa cold antibody with Pra specificity , 1990, Transfusion.

[2]  M. Klein,et al.  Isotype modulation of idiotypic expression in recombinant isotypic variants of MOPC 315. , 1990, Journal of immunology.

[3]  D. Roelcke.  Cold agglutination. , 1989, Transfusion medicine reviews.

[4]  R. Cronkhite,et al.  A novel idiotopic determinant on phosphorylcholine-binding immunoglobulins restricted to isotype and allotype. , 1986, Journal of Immunology.

[5]  Z. Ota,et al.  A monoclonal IgM/kappa cold agglutinin bearing a new anti-Sa subspecificity. , 1985, Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society.

[6]  J. Claflin,et al.  IgA isotype-restricted idiotypes associated with T15 Id+ PC antibodies. , 1985, Journal of immunology.

[7]  M. Hummel,et al.  Altered membrane sialoglycoproteins in human erythrocytes lacking the Gerbich blood group antigens. , 1985, Biological chemistry Hoppe-Seyler.

[8]  D. Roelcke,et al.  Characterization of various anti‐Pr cold agglutinins , 1984, Transfusion.

[9]  S. Rudikoff,et al.  Galactan-binding antibodies. Diversity and structure of idiotypes , 1983, The Journal of experimental medicine.

[10]  C. Berek,et al.  An idiotypic determinant formed by both immunoglobulin constant and variable regions , 1983, Nature.

[11]  W. Dahr,et al.  Studies on the Receptor Sites of the Monoclonal Anti-Pr and-Sa Cold Agglutinins , 1982 .

[12]  W. Dahr,et al.  Comparison of alkali-labile oligosaccharide chains of m and n blood-group glycopeptides from human erythrocyte membrane , 1980 .

[13]  W. Pruzanski,et al.  A new human monoclonal cold agglutinin Sa recognizing terminal N-acetylneuraminyl groups on the cell surface. , 1980, Blood.

[14]  D. Roelcke,et al.  Anti‐Pr3: Serological and Immunochemical Identification of a New Anti‐Pr Subspecificity , 1976, Vox sanguinis.

[15]  T. Feizi,et al.  Studies on the specificities of two IgM lambda cold agglutinins. , 1974, Immunology.

[16]  I. Brodsky,et al.  An IgA High‐Titer Cold Agglutinin with an Unusual Blood Group Specificity within the Pr Complex 1 , 1973, Vox sanguinis.

[17]  D. Roelcke,et al.  Modifications of N-acetylneuraminic acid and their influence on the antigen activity of erythrocyte glycoproteins. , 1972, European journal of biochemistry.

[18]  D. Roelcke.  [Peculiarities in the reactivity of a plasmacytoma-gamma A-paraprotein identical cold agglutinin]. , 1968, Klinische Wochenschrift.

[19]  B. Andersen,et al.  A cold agglutinin of the IgA class. , 1966, Journal of immunology.