Regional and Temporal Nonuniformity of Shape and Wall Movement in the Normal Left Ventricle

Asymmetry of left ventricular (LV) shape and asynchrony of regional LV movement have been described in the normal human heart, but never correlated to each other. In 16 normal subjects, right anterior oblique ventriculography was used to obtain volumes, regional wall motion (centerline method) and curvature (windowed Fourier series approximation of contours) over the entire cardiac cycle. The apex had the greatest curvature, while the posterior wall had a negative end-diastolic curvature that decreased further at early-systole and became positive at end-systole. The anterior region had the greatest and the anteroapical region the least fractional shortening. Asynchrony was evident as a delayed contraction of the infero- and anteroapical regions, and as a greater rate of late-systolic shortening of the anterior wall than that of the apex. Shape changes and shortening were dyssynchronous in the apical regions where the greatest changes occurred at early diastole. Temporal and regional nonuniformity of shape and movement exists in normal subjects. Dyssynchrony between shape and regional contraction of the apical regions deserves further studies.

[1]  G. Mancini,et al.  Quantitative regional curvature analysis: an application of shape determination for the assessment of segmental left ventricular function in man. , 1987, American heart journal.

[2]  G. Hutchins,et al.  Catenoid Shape of the Interventricular Septum: Possible Cause of Idiopathic Hypertrophic Subaortic Stenosis , 1978, Circulation.

[3]  Frank E. Rademakers,et al.  Dissociation Between Left Ventricular Untwisting and Filling: Accentuation by Catecholamines , 1992, Circulation.

[4]  H D McIntosh,et al.  Assessment of regional myocardial performance from biplane coronary cineangiograms. , 1971, The American journal of cardiology.

[5]  D G Gibson,et al.  Analysis of left ventricular wall movement during isovolumic relaxation and its relation to coronary artery disease. , 1976, British heart journal.

[6]  H W Woo,et al.  Advantages and applications of the centerline method for characterizing regional ventricular function. , 1986, Circulation.

[7]  P D Clayton,et al.  The Characteristic Sequence for the Onset of Contraction in the Normal Human Left Ventricle , 1979, Circulation.

[8]  E R Bates,et al.  Quantitative regional curvature analysis: a prospective evaluation of ventricular shape and wall motion measurements. , 1988, American heart journal.

[9]  D G Gibson,et al.  Regional non-uniformity of left ventricular wall movement in man. , 1981, British heart journal.

[10]  A E Becker,et al.  Left ventricular fibre architecture in man. , 1981, British heart journal.

[11]  W L Maughan,et al.  Abnormalities of Dynamic Ventricular Shape Change in Patients With Aortic and Mitral Valvular Regurgitation: Assessment by Fourier Shape Analysis and Global Geometric Indexes , 1988, Circulation research.

[12]  Edward L. Bolson,et al.  MEASUREMENT OF ABNORMALITIES IN THE TIMING AND EXTENT OF MOTION FROM FRAME-BY-FRAME ANALYSIS OF CONTRAST LEFT VENTRICULOGRAMS. , 1983 .

[13]  B. Chaitman,et al.  Objective and Subjective Analysis of Left Ventricular Angiograms , 1975, Circulation.

[14]  R Beyar,et al.  Noninvasive quantification of left ventricular rotational deformation in normal humans using magnetic resonance imaging myocardial tagging. , 1990, Circulation.

[15]  D. Gibson,et al.  Limitations of two frame method for displaying regional left ventricular wall motion in man. , 1980, British heart journal.

[16]  S M Collins,et al.  Heterogeneity of left ventricular segmental wall thickening and excursion in 2-dimensional echocardiograms of normal human subjects. , 1983, The American journal of cardiology.

[17]  D. Brutsaert,et al.  Nonuniformity: a physiologic modulator of contraction and relaxation of the normal heart. , 1987, Journal of the American College of Cardiology.

[18]  M. Marcus,et al.  Temporal Heterogeneity of Myocardial Blood Flow in Anesthetized Dogs , 1975, Circulation.

[19]  D G Gibson,et al.  Continuous assessment of left ventricular shape in man. , 1975, British heart journal.

[20]  Maurizio Baroni,et al.  Digital curvature estimation for left ventricular shape analysis , 1992, Image Vis. Comput..

[21]  K Wildenthal,et al.  Geometrical studies of the left ventricle utilizing biplane cinefluorography. , 1969, Federation proceedings.

[22]  J W Covell,et al.  Regional Differences in Myocardial Performance in the Left Ventricle of the Dog , 1975, Circulation research.

[23]  M. Baroni,et al.  Model simulation of a curvature matching algorithm to assess systolic and diastolic LV wall motion , 1992, Proceedings Computers in Cardiology.

[24]  D G Gibson,et al.  Regional non-uniformity of wall dynamics in normal left ventricle. , 1981, British heart journal.