Transformation Oncogenic Signaling during Cell Protein Levels Reflect a Nexus ofkip 1 p 27 Molecular Bases of Disease

[1]  A. Lorenzini,et al.  53BP1 contributes to a robust genomic stability in human fibroblasts , 2011, Aging.

[2]  Cheng-Wei Wu,et al.  The B56γ3 Regulatory Subunit of Protein Phosphatase 2A (PP2A) Regulates S Phase-specific Nuclear Accumulation of PP2A and the G1 to S Transition* , 2010, The Journal of Biological Chemistry.

[3]  M. Resh,et al.  Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27 deficient mice with growth-factor induced oligodendrogliomas , 2009, Oncogene.

[4]  S. Jhanwar,et al.  Retinoblastoma Has Properties of a Cone Precursor Tumor and Depends Upon Cone-Specific MDM2 Signaling , 2009, Cell.

[5]  W. Hahn,et al.  Multiple pathways regulated by the tumor suppressor PP2A in transformation. , 2008, Trends in molecular medicine.

[6]  G. Longton,et al.  p27kip1 Deficiency Impairs G2/M Arrest in Response to DNA Damage, Leading to an Increase in Genetic Instability , 2007, Molecular and Cellular Biology.

[7]  W. Hahn,et al.  Structural Basis of PP2A Inhibition by Small t Antigen , 2007, PLoS biology.

[8]  W. Hahn,et al.  The Tumor Suppressor PP2A Aβ Regulates the RalA GTPase , 2007, Cell.

[9]  Jennifer B. Old,et al.  Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis , 2007, The EMBO journal.

[10]  G. Stein,et al.  Cooperation between p27 and p107 during Endochondral Ossification Suggests a Genetic Pathway Controlled by p27 and p130 , 2007, Molecular and Cellular Biology.

[11]  James M. Roberts,et al.  Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer , 2006, Proceedings of the National Academy of Sciences.

[12]  James M. Roberts,et al.  A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. , 2006, Genes & development.

[13]  J. Pipas,et al.  SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation , 2005, Oncogene.

[14]  Xuedong Liu,et al.  Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling , 2005, Molecular and Cellular Biology.

[15]  S. Rafii,et al.  p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. Viale,et al.  Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[17]  T. Akagi Oncogenic transformation of human cells: shortcomings of rodent model systems. , 2004, Trends in molecular medicine.

[18]  W. Hahn,et al.  Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56γ Knockdown , 2004, Cancer Research.

[19]  R. Weinberg,et al.  Species- and cell type-specific requirements for cellular transformation. , 2004, Cancer cell.

[20]  F. Traganos,et al.  Noncatalytic Requirement for Cyclin A-cdk2 in p27 Turnover , 2004, Molecular and Cellular Biology.

[21]  K. Rundell,et al.  Cellular Targets of the SV40 Small-t Antigen in Human Cell Transformation , 2004, Cell cycle.

[22]  Joseph R. Nevins,et al.  A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells , 2004, Nature Cell Biology.

[23]  H. Hanafusa,et al.  Human Diploid Fibroblasts are Refractory to Oncogene-Mediated Transformation , 2004, Cell cycle.

[24]  W. Hahn,et al.  Identification of specific PP2A complexes involved in human cell transformation. , 2004, Cancer cell.

[25]  H. Hanafusa,et al.  Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[26]  W. Hahn,et al.  Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. , 2003, Cancer cell.

[27]  P. Pandolfi,et al.  p27 deficiency desensitizes Rb−/− cells to signals that trigger apoptosis during pituitary tumor development , 2003, Oncogene.

[28]  G. Hannon,et al.  Transformation of normal human cells in the absence of telomerase activation. , 2002, Cancer cell.

[29]  Alfonso Bellacosa,et al.  Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer , 2002, Nature Medicine.

[30]  Carlos L. Arteaga,et al.  PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization , 2002, Nature Medicine.

[31]  Takashi Tsuruo,et al.  Akt-dependent Phosphorylation of p27Kip1Promotes Binding to 14-3-3 and Cytoplasmic Localization* , 2002, The Journal of Biological Chemistry.

[32]  A. Koff,et al.  Rho Activity Can Alter the Translation of p27 mRNA and Is Important for RasV12-induced Transformation in a Manner Dependent on p27 Status* , 2002, The Journal of Biological Chemistry.

[33]  Robert A. Weinberg,et al.  Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation , 2002, Molecular and Cellular Biology.

[34]  J. Slingerland,et al.  PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest , 2002, Nature Medicine.

[35]  K. Rundell,et al.  Critical role for SV40 small-t antigen in human cell transformation. , 2001, Virology.

[36]  F. Alt,et al.  Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. , 2000, Genes & development.

[37]  W. Ansorge,et al.  Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27 , 1999, The EMBO journal.

[38]  B. Hemmings,et al.  Regulation of protein kinase cascades by protein phosphatase 2A. , 1999, Trends in biochemical sciences.

[39]  M. Mumby,et al.  Identification of Structural Elements Involved in the Interaction of Simian Virus 40 Small Tumor Antigen with Protein Phosphatase 2A* , 1998, The Journal of Biological Chemistry.

[40]  R. Yeung,et al.  Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Matusik,et al.  Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. , 1998, Laboratory investigation; a journal of technical methods and pathology.

[42]  N. Bouck,et al.  A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays , 1996, Journal of virology.

[43]  R. Matusik,et al.  Prostate cancer in a transgenic mouse. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[44]  M. Mumby,et al.  Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation , 1994, Journal of virology.

[45]  M. Mumby,et al.  The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation , 1993, Cell.

[46]  M. Mumby,et al.  Control of protein phosphatase 2A by simian virus 40 small-t antigen , 1991, Molecular and cellular biology.

[47]  M. Mumby,et al.  Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen , 1991, Molecular and cellular biology.

[48]  J. Sambrook,et al.  Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells , 1978, Cell.

[49]  N. Bouck,et al.  New region of the simian virus 40 genome required for efficient viral transformation. , 1978, Proceedings of the National Academy of Sciences of the United States of America.