Interleukin‐12 inhibits eosinophil differentiation from bone marrow stem cells in an interferon‐γ‐dependent manner in a mouse model of asthma

Background  Intrapulmonary administration of IL‐12 has been shown to inhibit the number of eosinophils in lung murine models of asthma, but the precise mechanism of this inhibition has not been reported. The purpose of this study was to examine whether IL‐12 treatment inhibits bone marrow eosinophilopoiesis, and to elucidate the role of IFN‐γ in this process.

[1]  J. Reimann,et al.  IL-12/IL-18-Dependent IFN-γ Release by Murine Dendritic Cells1 , 2001, The Journal of Immunology.

[2]  J. Lötvall,et al.  Eosinophilopoiesis in A Murine Model of Allergic Airway Eosinophilia: Involvement of Bone Marrow IL-5 and IL-5 Receptor α1 , 2000, The Journal of Immunology.

[3]  M. Jordana,et al.  IL‐12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure , 2000, Allergy.

[4]  M. Kurimoto,et al.  Identification of IFN-γ-Producing Cells in IL-12/IL-18-Treated Mice , 1999 .

[5]  P. O'Byrne,et al.  Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice. , 1999, American journal of respiratory cell and molecular biology.

[6]  S. Stafford,et al.  A novel Lyn-binding peptide inhibitor blocks eosinophil differentiation, survival, and airway eosinophilic inflammation. , 1999, Journal of immunology.

[7]  S. Holgate,et al.  The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma , 1999, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[8]  P. O'Byrne,et al.  Regulation of IL–5 and IL–5 Receptor Expression in the Bone Marrow of Allergic Asthmatics , 1999, International Archives of Allergy and Immunology.

[9]  J. Tavernier,et al.  Eosinophil Development and Bone Marrow and Tissue Eosinophils in Atopic Asthma , 1999, International Archives of Allergy and Immunology.

[10]  R. Egan,et al.  Interleukin-5 expression in the bone marrow of sensitized Balb/c mice after allergen challenge. , 1998, American journal of respiratory and critical care medicine.

[11]  E. Gelfand,et al.  Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice. , 1998, The Journal of allergy and clinical immunology.

[12]  Klaus Eichmann,et al.  Murine Macrophages Secrete Interferon γ upon Combined Stimulation with Interleukin (IL)-12 and IL-18: A Novel Pathway of Autocrine Macrophage Activation , 1998, The Journal of experimental medicine.

[13]  P. O'Byrne,et al.  Allergen challenge increases cell traffic between bone marrow and lung. , 1998, American journal of respiratory cell and molecular biology.

[14]  P. O'Byrne,et al.  Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. , 1997, The Journal of clinical investigation.

[15]  S. Rangwala,et al.  Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. , 1997, Journal of immunology.

[16]  B. Vargaftig,et al.  Rapid increase in bone-marrow eosinophil production and responses to eosinopoietic interleukins triggered by intranasal allergen challenge. , 1997, American journal of respiratory cell and molecular biology.

[17]  G. Gleich,et al.  Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. , 1997, The American journal of physiology.

[18]  P. O'Byrne,et al.  Bone marrow progenitors in allergic airways diseases: studies in canine and human models. , 1997, International archives of allergy and immunology.

[19]  A. Nakao,et al.  Interleukin-12 prevents antigen-induced eosinophil recruitment into mouse airways. , 1996, American journal of respiratory and critical care medicine.

[20]  D. Holbert,et al.  Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses. , 1996, Journal of immunology.

[21]  P. O'Byrne,et al.  Allergen-induced increase in bone marrow progenitors in airway hyperresponsive dogs: regulation by a serum hemopoietic factor. , 1996, American journal of respiratory cell and molecular biology.

[22]  R. Pauwels,et al.  Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. , 1996, American journal of respiratory and critical care medicine.

[23]  F. Finkelman,et al.  Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice , 1995, The Journal of experimental medicine.

[24]  D. Broide,et al.  Eosinophilic inflammation is associated with elevation of interleukin-5 in the airways of patients with spontaneous symptomatic asthma. , 1995, The Journal of allergy and clinical immunology.

[25]  R. Egan,et al.  Effects of an antibody to interleukin-5 in a monkey model of asthma. , 1995, American journal of respiratory and critical care medicine.

[26]  P. O'Byrne,et al.  Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs. , 1995, International archives of allergy and immunology.

[27]  B. Ryffel,et al.  The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo , 1995, The Journal of experimental medicine.

[28]  D. Carvajal,et al.  Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen. , 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

[29]  R. Pauwels,et al.  Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. , 1995, American journal of respiratory cell and molecular biology.

[30]  P. O'Byrne,et al.  Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs and the effect of inhaled budesonide on these parameters. , 1994, American journal of respiratory cell and molecular biology.

[31]  A. Nakao,et al.  IFN-alpha inhibits antigen-induced eosinophil and CD4+ T cell recruitment into tissue. , 1994, Journal of immunology.

[32]  F. Finkelman,et al.  Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. , 1994, Journal of immunology.

[33]  H. Nakajima,et al.  Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea. , 1993, The American review of respiratory disease.

[34]  S. Durham,et al.  Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. , 1993, The Journal of allergy and clinical immunology.

[35]  G. Trinchieri,et al.  Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells , 1993, The Journal of experimental medicine.

[36]  H. Nakajima,et al.  Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells , 1993, The Journal of experimental medicine.

[37]  G. Trinchieri,et al.  Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers , 1991, The Journal of experimental medicine.

[38]  G. Gleich,et al.  Human eosinophil major basic protein induces airway constriction and airway hyperresponsiveness in primates. , 1991, The Journal of clinical investigation.

[39]  T. Suda,et al.  Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor , 1988, The Journal of experimental medicine.

[40]  N. Yamaguchi,et al.  T Cell‐Replacing Factor (TRF)/Interleukin 5 (IL‐5): Molecular and Functional Properties , 1988, Immunological reviews.

[41]  C. Sanderson,et al.  Molecular and Cellular Biology of Eosinophil Differentiation Factor (Interleukin‐5) and its Effects on Human and Mouse B Cells , 1988, Immunological reviews.

[42]  G. Gleich,et al.  The eosinophil and the pathophysiology of asthma. , 1986, The Journal of allergy and clinical immunology.

[43]  J. Reimann,et al.  IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells. , 2001, Journal of immunology.

[44]  M. V. Van Scott,et al.  Mucosal IL-12 inhibits airway reactivity to methacholine and respiratory failure in murine asthma. , 2000, Experimental lung research.

[45]  M. V. Van Scott,et al.  Mucosal IL-12 is more effective than systemic IL-12 in augmenting IFN-gamma expression and inhibiting allergic lung eosinophilia in murine lungs. , 2000, Experimental lung research.

[46]  H. Kuo,et al.  Upregulation of IL-5 receptor expression on bone marrow-derived CD34+ cells from patients with asthma. , 1999, Changgeng yi xue za zhi.

[47]  M. Kurimoto,et al.  Identification of IFN-gamma-producing cells in IL-12/IL-18-treated mice. , 1999, Cellular immunology.

[48]  P. O'Byrne,et al.  Changes in bone marrow inflammatory cell progenitors after inhaled allergen in asthmatic subjects. , 1998, American journal of respiratory and critical care medicine.

[49]  U. Verma,et al.  Interleukin-12 (IL-12) alone or in synergistic combination with IL-2 for in vitro activation of human bone marrow: differential effects at different time points. , 1995, Bone marrow transplantation.

[50]  D. Hyde,et al.  Eosinophils cause acute edematous injury in isolated perfused rat lungs. , 1990, The American review of respiratory disease.