Sphingosine-1-phosphate: an enigmatic signalling lipid

[1]  Darrell R. Abernethy,et al.  International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels , 2003, Pharmacological Reviews.

[2]  H. Riezman,et al.  Lcb4p Is a Key Regulator of Ceramide Synthesis from Exogenous Long Chain Sphingoid Base in Saccharomyces cerevisiae* , 2003, The Journal of Biological Chemistry.

[3]  A. Kihara,et al.  Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2* , 2003, The Journal of Biological Chemistry.

[4]  M. Vadas,et al.  The Nucleotide-binding Site of Human Sphingosine Kinase 1* , 2002, The Journal of Biological Chemistry.

[5]  R. Lester,et al.  Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes , 2002, FEBS letters.

[6]  J. P. Hobson,et al.  Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. , 2002, Experimental cell research.

[7]  Weicheng Wu,et al.  Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases , 2002, Molecular and Cellular Biology.

[8]  B. Berk,et al.  Transactivation of Vascular Endothelial Growth Factor (VEGF) Receptor Flk-1/KDR Is Involved in Sphingosine 1-Phosphate-stimulated Phosphorylation of Akt and Endothelial Nitric-oxide Synthase (eNOS)* , 2002, The Journal of Biological Chemistry.

[9]  E. Goetzl,et al.  Cutting Edge: Suppression of T Cell Chemotaxis by Sphingosine 1-Phosphate1 , 2002, The Journal of Immunology.

[10]  V. Brinkmann,et al.  FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. , 2002, Current opinion in immunology.

[11]  Korey R. Johnson,et al.  PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane , 2002, The Journal of Biological Chemistry.

[12]  S. Milstien,et al.  Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis , 2002, The Journal of cell biology.

[13]  T. Okada,et al.  Identification and Characterization of RPK118, a Novel Sphingosine Kinase-1-binding Protein* , 2002, The Journal of Biological Chemistry.

[14]  S. Milstien,et al.  Cloning and Characterization of a Protein Kinase A Anchoring Protein (AKAP)-related Protein That Interacts with and Regulates Sphingosine Kinase 1 Activity* , 2002, The Journal of Biological Chemistry.

[15]  Yusuf A. Hannun,et al.  The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind* , 2002, The Journal of Biological Chemistry.

[16]  S. Milstien,et al.  Sphingosine 1-Phosphate, a Key Cell Signaling Molecule* , 2002, The Journal of Biological Chemistry.

[17]  Alfred H. Merrill,et al.  De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway* , 2002, The Journal of Biological Chemistry.

[18]  J. Chun,et al.  Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3* , 2002, The Journal of Biological Chemistry.

[19]  R. Kolesnick.  The therapeutic potential of modulating the ceramide/sphingomyelin pathway. , 2002, The Journal of clinical investigation.

[20]  Michael D. Davis,et al.  The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors* , 2002, The Journal of Biological Chemistry.

[21]  Kevin R. Lynch,et al.  International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature , 2002, Pharmacological Reviews.

[22]  S. Spiegel,et al.  Lipid mediators of angiogenesis and the signalling pathways they initiate. , 2002, Biochimica et biophysica acta.

[23]  K. Lynch,et al.  Lysophospholipid receptor nomenclature. , 2002, Biochimica et biophysica acta.

[24]  A. Melendez,et al.  Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells* , 2002, The Journal of Biological Chemistry.

[25]  H. Rosen,et al.  Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists , 2002, Science.

[26]  Chen-Yong Lin,et al.  Sphingosine 1-Phosphate, Present in Serum-derived Lipoproteins, Activates Matriptase* , 2002, The Journal of Biological Chemistry.

[27]  S. Milstien,et al.  Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase* , 2002, The Journal of Biological Chemistry.

[28]  J. Gamble,et al.  Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling* , 2002, The Journal of Biological Chemistry.

[29]  M. Maceyka,et al.  Sphingosine kinases: a novel family of lipid kinases. , 2002, Progress in nucleic acid research and molecular biology.

[30]  J. P. Hobson,et al.  EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[31]  T. Hla,et al.  Lysophospholipids--Receptor Revelations , 2001, Science.

[32]  J. P. Hobson,et al.  The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. , 2001, Biochemical Society transactions.

[33]  G. Li,et al.  Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. , 2001, Development.

[34]  A. Verin,et al.  Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. , 2001, The Journal of clinical investigation.

[35]  G P Sapkota,et al.  Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. , 2001, Molecular cell.

[36]  Junsuke Igarashi,et al.  Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase β , 2001, The Journal of Biological Chemistry.

[37]  A. Bielawska,et al.  Biochemical Characterization of the Reverse Activity of Rat Brain Ceramidase , 2001, The Journal of Biological Chemistry.

[38]  K. Jakobs,et al.  Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors. , 2001, Life sciences.

[39]  Y. Hannun,et al.  Induction of Apoptosis through B-cell Receptor Cross-linking Occurs via de Novo Generated C16-Ceramide and Involves Mitochondria* , 2001, The Journal of Biological Chemistry.

[40]  S. Chae,et al.  Sphingosine 1-Phosphate-induced Endothelial Cell Migration Requires the Expression of EDG-1 and EDG-3 Receptors and Rho-dependent Activation of αvβ3- and β1-containing Integrins* , 2001, The Journal of Biological Chemistry.

[41]  K. Cunningham,et al.  Calcium Influx and Signaling in Yeast Stimulated by Intracellular Sphingosine 1-Phosphate Accumulation* , 2001, The Journal of Biological Chemistry.

[42]  A. Hetherington,et al.  Drought-induced guard cell signal transduction involves sphingosine-1-phosphate , 2001, Nature.

[43]  Y. Hannun,et al.  Role for de Novo Sphingoid Base Biosynthesis in the Heat-induced Transient Cell Cycle Arrest of Saccharomyces cerevisiae * , 2001, The Journal of Biological Chemistry.

[44]  J. P. Hobson,et al.  Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility , 2001, Science.

[45]  S. Milstien,et al.  Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells , 2001, Journal of neurochemistry.

[46]  D. Mastronarde,et al.  Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[47]  T. Michel,et al.  Sphingosine 1-Phosphate and Isoform-specific Activation of Phosphoinositide 3-Kinase (cid:1) EVIDENCE FOR DIVERGENCE AND CONVERGENCE OF RECEPTOR-REGULATED ENDOTHELIAL NITRIC-OXIDE SYNTHASE SIGNALING PATHWAYS* , 2001 .

[48]  N. Sugimoto,et al.  Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3 , 2000 .

[49]  J. Gamble,et al.  An oncogenic role of sphingosine kinase , 2000, Current Biology.

[50]  J. P. Hobson,et al.  Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. , 2000, The Journal of clinical investigation.

[51]  J. Vermeesch,et al.  Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). , 2000, Biochimica et biophysica acta.

[52]  D. Stainier,et al.  A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development , 2000, Nature.

[53]  W. Driever.  Developmental biology: Bringing two hearts together , 2000, Nature.

[54]  S. Spiegel,et al.  Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[55]  G. van Meer,et al.  Sphingolipid transport in eukaryotic cells. , 2000, Biochimica et biophysica acta.

[56]  H. Riezman,et al.  Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae , 2000, The EMBO journal.

[57]  Y. Hannun,et al.  Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis* , 2000, The Journal of Biological Chemistry.

[58]  K. Jakobs,et al.  Role of sphingosine kinase in Ca2+ signalling by epidermal growth factor receptor , 1999, FEBS letters.

[59]  S. Spiegel,et al.  Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival , 1999, The Journal of cell biology.

[60]  K. Claffey,et al.  Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate , 1999, Cell.

[61]  L. Obeid,et al.  The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. , 1999, The Biochemical journal.

[62]  Y. Hannun,et al.  Ceramide and apoptosis. , 1999, Trends in biochemical sciences.

[63]  W. Heideman,et al.  TheDPL1Gene Is Involved in Mediating the Response to Nutrient Deprivation inSaccharomyces cerevisiae , 1999 .

[64]  W. Heideman,et al.  The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. , 1999, Molecular cell biology research communications : MCBRC.

[65]  G. Carman,et al.  Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. , 1999, The Biochemical journal.

[66]  R. Penner,et al.  Calcium Release-activated Calcium Current (I CRAC) Is a Direct Target for Sphingosine* , 1998, The Journal of Biological Chemistry.

[67]  S. Spiegel,et al.  Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase* , 1998, The Journal of Biological Chemistry.

[68]  R. Clément,et al.  Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways. , 1998, Glycobiology.

[69]  M. Skrzypek,et al.  The LCB4 (YOR171c) and LCB5(YLR260w) Genes of Saccharomyces Encode Sphingoid Long Chain Base Kinases* , 1998, The Journal of Biological Chemistry.

[70]  A. Hall,et al.  G Proteins and Small GTPases: Distant Relatives Keep in Touch , 1998, Science.

[71]  Chunyi Zhang,et al.  Sphingosine kinase‐mediated Ca2+ signalling by G‐protein‐coupled receptors , 1998, The EMBO journal.

[72]  C. H. Liu,et al.  Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. , 1998, Science.

[73]  J. Zhou,et al.  Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. , 1998, Biochemical and biophysical research communications.

[74]  J. Broach,et al.  Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[75]  Y. Hannun,et al.  Identification and Characterization of Saccharomyces cerevisiae Dihydrosphingosine-1-phosphate Phosphatase* , 1997, The Journal of Biological Chemistry.

[76]  G. van Echten-Deckert,et al.  Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum , 1997, FEBS letters.

[77]  S. Garrett,et al.  The BST1 Gene of Saccharomyces cerevisiaeIs the Sphingosine-1-phosphate Lyase* , 1997, The Journal of Biological Chemistry.

[78]  R. Lester,et al.  Identification of a Saccharomyces Gene,LCB3, Necessary for Incorporation of Exogenous Long Chain Bases into Sphingolipids* , 1997, The Journal of Biological Chemistry.

[79]  K. Sandhoff,et al.  cis-4-Methylsphingosine Decreases Sphingolipid Biosynthesis by Specifically Interfering with Serine Palmitoyltransferase Activity in Primary Cultured Neurons* , 1997, The Journal of Biological Chemistry.

[80]  G. Carman,et al.  Identification of a novel phosphatase sequence motif , 1997, Protein science : a publication of the Protein Society.

[81]  Y. Hannun.  Functions of Ceramide in Coordinating Cellular Responses to Stress , 1996, Science.

[82]  S. Spiegel,et al.  Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate , 1996, Nature.

[83]  J. Kinet,et al.  Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor , 1996, Nature.

[84]  K. Scotto,et al.  Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals , 1995, Cell.

[85]  D. Gill,et al.  Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. , 1994, The Journal of biological chemistry.

[86]  S. Spiegel,et al.  Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. , 1994, The Journal of biological chemistry.

[87]  S. Spiegel,et al.  Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens , 1993, Nature.

[88]  S. Spiegel,et al.  Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation , 1991, The Journal of cell biology.

[89]  D. Gill,et al.  Intracellular calcium release mediated by sphingosine derivatives generated in cells. , 1990, Science.

[90]  B. Stieger,et al.  Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. , 1990, The Journal of biological chemistry.

[91]  W. Stoffel,et al.  Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate. , 1970, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.