Improved AI-based segmentation of apical and basal slices from clinical cine CMR

Current artificial intelligence (AI) algorithms for short-axis cardiac magnetic resonance (CMR) segmentation achieve human performance for slices situated in the middle of the heart. However, an oftenoverlooked fact is that segmentation of the basal and apical slices is more difficult. During manual analysis, differences in the basal segmentations have been reported as one of the major sources of disagreement in human interobserver variability. In this work, we aim to investigate the performance of AI algorithms in segmenting basal and apical slices and design strategies to improve their segmentation. We trained all our models on a large dataset of clinical CMR studies obtained from two NHS hospitals (n=4,228) and evaluated them against two external datasets: ACDC (n=100) and M&Ms (n=321). Using manual segmentations as a reference, CMR slices were assigned to one of four regions: non-cardiac, base, middle, and apex. Using the ‘nnU-Net’ framework as a baseline, we investigated two different approaches to reduce the segmentation performance gap between cardiac regions: (1) non-uniform batch sampling, which allows us to choose how often images from different regions are seen during training; and (2) a cardiac-region classification model followed by three (i.e. base, middle, and apex) region-specific segmentation models. We show that the classification and segmentation approach was best at reducing the performance gap across all datasets. We also show that improvements in the classification performance can subsequently lead to a significantly better performance in the segmentation task.