Efficient synthesis and chiral separation of 11C-labeled ibuprofen assisted by DMSO for imaging of in vivo behavior of the individual isomers by positron emission tomography.

[1]  Ming-Rong Zhang,et al.  Tetrabutylammonium fluoride-promoted α-[11C]methylation of α-arylesters: a simple and robust method for the preparation of 11C-labeled ibuprofen , 2010 .

[2]  H. Onoe,et al.  General method for the (11)C-labeling of 2-arylpropionic acids and their esters: construction of a PET tracer library for a study of biological events involved in COXs expression. , 2010, Chemistry.

[3]  Paul Blum,et al.  Use of a Robust Dehydrogenase from an Archael Hyperthermophile in Asymmetric Catalysis−Dynamic Reductive Kinetic Resolution Entry into (S)-Profens , 2010, Journal of the American Chemical Society.

[4]  Peng Li,et al.  Chiral separation of ibuprofen and chiral pharmacokinetics in healthy chinese volunteers , 2010, European Journal of Drug Metabolism and Pharmacokinetics.

[5]  Douglas W Mahoney,et al.  Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) and the role of ethanol and radioactive concentration. , 2009, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[6]  H. Kung,et al.  Studies into radiolytic decomposition of fluorine-18 labeled radiopharmaceuticals for positron emission tomography. , 2009, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[7]  T. V. RajanBabu,et al.  Efficient, selective, and green: catalyst tuning for highly enantioselective reactions of ethylene. , 2008, Organic letters.

[8]  D. Fradelizi,et al.  Ultrasound and Doppler micro-imaging in a model of rheumatoid arthritis in mice , 2008, Annals of the rheumatic diseases.

[9]  R. M. Fawdry Radiolysis of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) and the role of reductant stabilisers. , 2007, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[10]  B. List,et al.  Catalytic asymmetric hydrogenation of aldehydes. , 2007, Chemical communications.

[11]  Fatima S. Khwaja,et al.  The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells. , 2007, Cancer research.

[12]  F. Russel,et al.  Interaction of Nonsteroidal Anti-Inflammatory Drugs with Multidrug Resistance Protein (MRP) 2/ABCC2- and MRP4/ABCC4-Mediated Methotrexate Transport , 2007, Journal of Pharmacology and Experimental Therapeutics.

[13]  P. Schubiger,et al.  Automated no-carrier-added synthesis of [1-11C]-labeled D- and L-enantiomers of lactic acid. , 2006, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[14]  D. Belmont,et al.  A novel asymmetric synthesis of tritium and carbon‐14 labeled (R)‐ibuprofen , 2006 .

[15]  Haoran Sun,et al.  Anhydrous tetrabutylammonium fluoride. , 2005, Journal of the American Chemical Society.

[16]  R. Nakao,et al.  Stability of 11C-labeled PET radiopharmaceuticals. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[17]  H. Kroemer,et al.  The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. , 2004, Blood.

[18]  S. Kaehler,et al.  Dexibuprofen: pharmacology, therapeutic uses and safety , 2003, InflammoPharmacology.

[19]  Valentina Gelfanova,et al.  Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß42 by Inhibiting Rho , 2003, Science.

[20]  A. Wunder,et al.  Albumin-Based Drug Delivery as Novel Therapeutic Approach for Rheumatoid Arthritis1 , 2003, The Journal of Immunology.

[21]  U. Gunten Ozonation of drinking water: part I. Oxidation kinetics and product formation. , 2003 .

[22]  R. Colin Garner,et al.  Big physics, small doses: the use of AMS and PET in human microdosing of development drugs , 2003, Nature Reviews Drug Discovery.

[23]  Gun-Young Park,et al.  Oxidation of pharmaceuticals during ozonation and advanced oxidation processes. , 2003, Environmental science & technology.

[24]  L. Benet,et al.  Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. , 2002, Chemical research in toxicology.

[25]  L. Goossen Asymmetric hydrovinylation: new perspectives through use of modular ligand systems. , 2002, Angewandte Chemie.

[26]  W. Knowles Asymmetric hydrogenations (Nobel lecture). , 2002, Angewandte Chemie.

[27]  Ryoji Noyori,et al.  Asymmetric catalysis: science and opportunities (Nobel lecture). , 2002, Angewandte Chemie.

[28]  Rong Wang,et al.  A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity , 2001, Nature.

[29]  Gerd Geisslinger,et al.  Cyclooxygenase‐independent actions of cyclooxygenase inhibitors , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  W. Lindner,et al.  Separation of enantiomers: needs, challenges, perspectives. , 2001, Journal of chromatography. A.

[31]  C. Sonntag,et al.  Reactions of phenol-OH-adduct radicals. Phenoxyl radical formation by water elimination vs. oxidation by dioxygen , 2001 .

[32]  M E Phelps,et al.  Positron emission tomography provides molecular imaging of biological processes. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[33]  J. Woodward,et al.  Detection of Transient Intermediates in the Photochemical Reaction of Hydrogen Peroxide with Dimethyl sulfoxide by Time-Resolved EPR Techniques , 2000 .

[34]  C. Crudden,et al.  Catalytic Asymmetric Hydrocarboxylation and Hydrohydroxymethylation. A Two-Step Approach to the Enantioselective Functionalization of Vinylarenes , 1999 .

[35]  J. Clark,et al.  The effect of basicity on fluorodenitration reactions using tetramethylammonium salts , 1999 .

[36]  M. Naruszewicz,et al.  Ibuprofen protects low density lipoproteins against oxidative modification. , 1999, Life sciences.

[37]  G Geisslinger,et al.  Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: a key enzyme in the inversion metabolism of ibuprofen. , 1997, Molecular pharmacology.

[38]  W. Oppolzer,et al.  Asymmetric synthesis of ibuprofen via diastereoselective alkylation of a homochiral N-acylbornanesultam , 1997 .

[39]  Y. Tsuda,et al.  Stereoselective pharmacokinetics of ibuprofen in rats: effect of enantiomer-enantiomer interaction in plasma protein binding. , 1997, Chirality.

[40]  M. Eandi,et al.  Preliminary pharmacokinetic study of ibuprofen enantiomers after administration of a new oral formulation (ibuprofen arginine) to healthy male volunteers. , 1997, Chirality.

[41]  Y. Tsuda,et al.  Stereoselectivity and enantiomer-enantiomer interactions in the binding of ibuprofen to human serum albumin. , 1997, Chirality.

[42]  K. Nozaki,et al.  Highly Efficient Enantioselective Synthesis of Optically Active Carboxylic Acids by Ru(OCOCH3)2[(S)-H8-BINAP] , 1996 .

[43]  Xian-Ming Pan,et al.  Oxidation of benzene by the OH radical. A product and pulse radiolysis study in oxygenated aqueous solution , 1993 .

[44]  A. Fadel Optically Active Arylpropionic Acids from the Stereoselective Alkylation of Chiral Imide Enolates1 , 1992 .

[45]  K. M. Subramanian Cardiac blood-pool tracers. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[46]  S. Cox,et al.  Pharmacokinetics of the R(−) and S(+) Enantiomers of Ibuprofen in the Serum and Synovial Fluid of Arthritis Patients , 1991, Journal of clinical pharmacology.

[47]  H. Alper,et al.  Asymmetric synthesis of acids by the palladium-catalyzed hydrocarboxylation of olefins in the presence of (R)-(-)- or (S)-(+)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate , 1990 .

[48]  P. McCay,et al.  Spin trapping of ibuprofen radicals: evidence that ibuprofen is a hydroxyl radical scavenger. , 1990, Free radical research communications.

[49]  M. Eberhardt,et al.  The reaction of OH radicals with dimethyl sulfoxide. A comparative study of Fenton's reagent and the radiolysis of aqueous dimethyl sulfoxide solutions , 1988 .

[50]  A. Wolf,et al.  Fluorine-18-N-methylspiroperidol: radiolytic decomposition as a consequence of high specific activity and high dose levels. , 1987, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[51]  K. Asmus,et al.  Primary processes in the reaction of OH·-radicals with sulphoxides , 1980 .

[52]  S. Adams,et al.  Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (—)‐isomer , 1976, The Journal of pharmacy and pharmacology.

[53]  J. Mialocq,et al.  Flash photolysis of dimethylsulphoxide , 1974 .

[54]  T Y Shen,et al.  Perspectives in nonsteroidal anti-inflammatory agents. , 1972, Angewandte Chemie.