STUDIES HAVE RARELY BEEN REPORTED of changes in the corneal epithelium in buphthalmic animals. Fox and Babinol found a sharp increase in cornified corneal epithelial cells in the buphthalmic rabbit, using the Giesma stain. Huber and Smith2 reported an increase in cornification of bovine bulbar conjunctival epithelium associated with vitamin A deficiency. Both of these reports are very brief. This study is an amplification of the work of Fox and Babino.1 various clinical procedures for the of test, some early cases are very difficult to diagnose accurately. This study on changes in the corneal epithelium of the rabbit was undertaken as part of our program of studies on diagnosis and to better determine the underly-ing causes of buphthalmia in the rabbit. It is anticipated that the findings may be applied to the more significant problem of glaucoma in man.
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