RandomForest Based Assessment of the hERG Channel Inhibition Potential for the Early Drug Cardiotoxicity Testing

[1]  C. G. Mohan,et al.  Computer-assisted methods in chemical toxicity prediction. , 2007, Mini reviews in medicinal chemistry.

[2]  Ajay N. Jain,et al.  Accurate and Interpretable Computational Modeling of Chemical Mutagenicity , 2008, J. Chem. Inf. Model..

[3]  Naomi L Kruhlak,et al.  Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans. Part A: use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities. , 2009, Regulatory toxicology and pharmacology : RTP.

[4]  Rory Curtis,et al.  A Novel Membrane Potential-Sensitive Fluorescent Dye Improves Cell-Based Assays for Ion Channels , 2002, Journal of biomolecular screening.

[5]  Luis G Valerio,et al.  In silico toxicology for the pharmaceutical sciences. , 2009, Toxicology and applied pharmacology.

[6]  Rita R. Patel,et al.  A High-Throughput HERG Potassium Channel Function Assay: An Old Assay with a New Look , 2002, Drug development and industrial pharmacy.

[7]  Cédric Merlot,et al.  Computational toxicology--a tool for early safety evaluation. , 2010, Drug discovery today.

[8]  E. Matthews,et al.  Prediction of drug-related cardiac adverse effects in humans--B: use of QSAR programs for early detection of drug-induced cardiac toxicities. , 2010, Regulatory toxicology and pharmacology : RTP.

[9]  Soo Sen Lee,et al.  Flux assays in high throughput screening of ion channels in drug discovery. , 2003, Assay and drug development technologies.

[10]  Ann M Richard,et al.  Exposure science and the U.S. EPA National Center for Computational Toxicology , 2010, Journal of Exposure Science and Environmental Epidemiology.

[11]  A. J. Pennington,et al.  [3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel? , 2001, European journal of pharmacology.

[12]  Jules C Hancox,et al.  Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes. , 2002, Journal of pharmacological and toxicological methods.

[13]  Naomi L Kruhlak,et al.  Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities. , 2009, Regulatory toxicology and pharmacology : RTP.

[14]  S. Polak,et al.  Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties , 2009, Journal of applied toxicology : JAT.

[15]  P. Negulescu,et al.  Cell-based assays and instrumentation for screening ion-channel targets. , 1999, Drug discovery today.

[16]  S. Polak,et al.  hERG in vitro interchange factors—development and verification , 2009, Toxicology mechanisms and methods.