Neighborhood Disadvantage and Breast Cancer–Specific Survival

Key Points Question Is living in a disadvantaged neighborhood associated with breast cancer–specific survival in a majority-minority population? Findings In this cohort study of 5027 patients with breast cancer, neighborhood disadvantage was associated with shorter breast cancer–specific survival. This finding was noted after adjusting for individual-level sociodemographic, comorbidity, breast cancer risk factor, access to care, tumor, and National Comprehensive Cancer Network guideline-concordant treatment characteristics. Meaning The findings of this study suggest unaccounted mechanisms associated with breast cancer–specific survival, such as unmeasured social and access to care barriers, and lays the foundation for future research evaluating whether neighborhood disadvantage leads to more aggressive tumor biologic factors through the accumulation of social and environmental stressors.