Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations.

[1]  Hiroyuki Yamamoto,et al.  BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes , 2005, Oncogene.

[2]  E. Sacco,et al.  Familial and hereditary prostate cancer by definition in an italian surgical series: clinical features and outcome. , 2005, European urology.

[3]  G. Wilding,et al.  Induction of AP‐1 activity by androgen activation of the androgen receptor in LNCaP human prostate carcinoma cells , 2005, The Prostate.

[4]  T. Rebbeck.  Genetics, disparities, and prostate cancer. , 2005, LDI issue brief.

[5]  D. Troyer,et al.  Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation. , 2005, Endocrine-related cancer.

[6]  I. Sesterhenn,et al.  World health organization classifications of tumours. pathology and genetics of tumours of the urinary system and male genital organs , 2005 .

[7]  D. Stern.  More than a Marker… Phosphorylated Akt in Prostate Carcinoma , 2004, Clinical Cancer Research.

[8]  P. Scardino,et al.  High Levels of Phosphorylated Form of Akt-1 in Prostate Cancer and Non-Neoplastic Prostate Tissues Are Strong Predictors of Biochemical Recurrence , 2004, Clinical Cancer Research.

[9]  C. Mol,et al.  Switching on kinases: oncogenic activation of BRAF and the PDGFR family , 2004, Nature Reviews Cancer.

[10]  R. Meacham,et al.  Mitogen Activated Protein kinase signal transduction pathways in the prostate , 2004, Cell Communication and Signaling.

[11]  D. Barford,et al.  Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF , 2004, Cell.

[12]  S. Cross,et al.  Distinct patterns of microsatellite instability are seen in tumours of the urinary tract , 2003, Oncogene.

[13]  Andrew D Sharrocks,et al.  Transcriptional regulation by the MAP kinase signaling cascades. , 2003, Gene.

[14]  C. Pritchard,et al.  Raf proteins and cancer: B-Raf is identified as a mutational target. , 2003, Biochimica et biophysica acta.

[15]  Kun-Liang Guan,et al.  Mechanisms of regulating the Raf kinase family. , 2003, Cellular signalling.

[16]  F. Sommerer,et al.  Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma , 2003, Gut.

[17]  P. Ladenson,et al.  BRAF mutation in papillary thyroid carcinoma. , 2003, Journal of the National Cancer Institute.

[18]  Yuri E Nikiforov,et al.  High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. , 2003, Cancer research.

[19]  P. Peltomäki.  Role of DNA mismatch repair defects in the pathogenesis of human cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  Richard Wooster,et al.  BRAF and RAS mutations in human lung cancer and melanoma. , 2002, Cancer research.

[21]  M. Meyerson,et al.  Missense mutations of the BRAF gene in human lung adenocarcinoma. , 2002, Cancer research.

[22]  M. Stratton,et al.  Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. , 2002, Cancer research.

[23]  R. Knuechel,et al.  Histologic-Genetic Mapping by Allele-Specific PCR Reveals Intraurothelial Spread of p53 Mutant Tumor Clones , 2002, Laboratory Investigation.

[24]  K. Kinzler,et al.  Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status , 2002, Nature.

[25]  L. Van Aelst,et al.  The RASputin effect. , 2002, Genes & development.

[26]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[27]  C. Pilarsky,et al.  No evidence for involvement of beta-catenin and APC in urothelial carcinomas. , 2002, International journal of oncology.

[28]  D. Troyer,et al.  Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[29]  D. Parkin,et al.  Global cancer statistics in the year 2000. , 2001, The Lancet. Oncology.

[30]  H. Moch,et al.  Tissue microarray (TMA) technology: miniaturized pathology archives for high‐throughput in situ studies , 2001, The Journal of pathology.

[31]  M Bolla,et al.  EAU guidelines on prostate cancer. , 2001, European urology.

[32]  K. Guan,et al.  Positive and negative regulation of Raf kinase activity and function by phosphorylation , 2001, The EMBO journal.

[33]  A. Papatsoris,et al.  Molecular 'palpation' of BPH: a tale of MAPK signalling? , 2001, Trends in molecular medicine.

[34]  H. Grönberg,et al.  Low frequency of microsatellite instability in hereditary prostate cancer , 2001, BJU international.

[35]  A. Tannapfel,et al.  Frequency of p16INK4A alterations and k-ras mutations in intrahepatic cholangiocarcinoma of the liver , 2000, Gut.

[36]  M E Hammond,et al.  Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. , 2000, Archives of pathology & laboratory medicine.

[37]  L. Sobin,et al.  World Health Organization classification of tumors , 2000, Cancer.

[38]  O. Bratt.  Hereditary prostate cancer , 2000, BJU international.

[39]  L. Luttrell,et al.  Activation of extracellular signal-regulated kinase in human prostate cancer. , 1999, The Journal of urology.

[40]  M. Kattan,et al.  Postoperative nomogram for disease recurrence after radical prostatectomy for prostate cancer. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[41]  H. Frierson,et al.  Activation of mitogen-activated protein kinase associated with prostate cancer progression. , 1999, Cancer research.

[42]  S Srivastava,et al.  A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. , 1998, Cancer research.

[43]  D. Carter.  TNM Classification of Malignant Tumors , 1998 .

[44]  J. Rüschoff,et al.  Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. , 1997, Cancer research.

[45]  A. Whittemore,et al.  Genetic predisposition to prostate cancer: Possible explanations for ethnic differences in risk , 1997, The Prostate.

[46]  T. Smyrk,et al.  Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review , 1996, Cancer.

[47]  H. Lynch,et al.  Extracolonic cancer in hereditary nonpolyposis colorectal cancer , 1993, Cancer.

[48]  T. Smyrk,et al.  Hereditary nonpolyposis colorectal cancer--Lynch syndromes I and II. , 1988, Gastroenterology clinics of North America.

[49]  S. Hinrichs,et al.  Structural evidence for the authenticity of the human retinoblastoma gene. , 1987, Science.

[50]  A. Knudson.  Mutation and cancer: statistical study of retinoblastoma. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[51]  A. S. Warthin.  HEREDITY WITH REFERENCE TO CARCINOMA: AS SHOWN BY THE STUDY OF THE CASES EXAMINED IN THE PATHOLOGICAL LABORATORY OF THE UNIVERSITY OF MICHIGAN, 1895-1913 , 1913 .

[52]  Diagnostic Pathology BioMed Central Review , 2006 .

[53]  R. Knuechel,et al.  Microdissection for detecting genetic aberrations in early and advanced human urinary bladder cancer. , 2005, Methods in molecular biology.

[54]  R. Knuechel,et al.  Deletions of chromosomes 9 and 8p in histologically normal urothelium of patients with bladder cancer. , 2005, European urology.

[55]  J. Rüschoff,et al.  Detection of microsatellite instability in human colorectal carcinomas using a non-radioactive PCR-based screening technique , 2004, Virchows Archiv.

[56]  Daniel Gioeli,et al.  Ras signaling in prostate cancer progression , 2004, Journal of cellular biochemistry.

[57]  R. Knuechel,et al.  No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract. , 2004, Oncology reports.

[58]  P. Meltzer,et al.  High frequency of BRAF mutations in nevi , 2003, Nature Genetics.

[59]  R. Scott,et al.  Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds. , 2001, American journal of human genetics.

[60]  T H Beaty,et al.  Family history and the risk of prostate cancer , 1990, The Prostate.