Suspended micro-ring resonator for enhanced biomolecule detection sensitivity

Silicon micro-ring biosensors demonstrate great potential for high sensitivity and multiplexed lab-on-chip systems. In this work, we characterize the sensing performance of suspended TM-mode silicon micro-ring resonators, 5 μm in radius, and demonstrate an enhanced sensitivity to molecular binding on the ring after suspension. In the TM-mode, the overall field intensity exists primarily outside of the waveguide core, with high electric field intensities present near the top and bottom surfaces. In traditional micro-ring resonators, only the top surface of the ring is available for surface analyte attachment, while the electric field intensity near the bottom surface dissipates by leaking into the underlying silicon dioxide substrate. In our approach, we suspend the TM-micro ring resonators in order to increase the surface area for binding events and increase the light-matter interaction with analytes. The suspended rings demonstrate excellent mechanical stability to multiple rinsing, soaking and nitrogen drying steps during the sensing procedure. We show that the resonance shift achieved by the suspended micro-rings after attachment of small chemical molecules and DNA is at least twice that of micro-rings supported by the silicon dioxide substrate.

[1]  L. Gervais,et al.  Microfluidic Chips for Point‐of‐Care Immunodiagnostics , 2011, Advanced materials.

[2]  Muzammil Iqbal,et al.  Characterization of the evanescent field profile and bound mass sensitivity of a label-free silicon photonic microring resonator biosensing platform. , 2010, Biosensors & bioelectronics.

[3]  Neil Genzlinger A. and Q , 2006 .

[4]  A Densmore,et al.  Label-free biosensor array based on silicon-on-insulator ring resonators addressed using a WDM approach. , 2010, Optics letters.

[5]  Steven G. Johnson,et al.  Perturbation theory for Maxwell's equations with shifting material boundaries. , 2002, Physical review. E, Statistical, nonlinear, and soft matter physics.

[6]  Feng Liang,et al.  Scalable photonic crystal chips for high sensitivity protein detection. , 2013, Optics express.

[7]  Samuel K Sia,et al.  Commercialization of microfluidic point-of-care diagnostic devices. , 2012, Lab on a chip.

[8]  P. Dumon,et al.  Silicon microring resonators , 2012 .

[9]  Steven G. Johnson,et al.  Photonic Crystals: Molding the Flow of Light , 1995 .

[10]  R. Baets,et al.  Multiplexed Antibody Detection With an Array of Silicon-on-Insulator Microring Resonators , 2009, IEEE Photonics Journal.

[11]  Lan Yang,et al.  Review Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices , 2012 .

[12]  Muzammil Iqbal,et al.  Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[13]  W. Marsden I and J , 2012 .

[14]  J. B. Rodriguez,et al.  Silicon-on-insulator spectrometers with integrated GaInAsSb photodiodes for wide-band spectroscopy from 1510 to 2300 nm. , 2013, Optics express.

[15]  Qianfan Xu,et al.  Silicon microring resonators with 1.5-μm radius , 2008 .

[16]  Guo-Qiang Lo,et al.  Silicon-based optoelectronic integrated circuit for label-free bio/chemical sensor. , 2013, Optics express.

[17]  Wei Shi,et al.  Silicon photonic micro-disk resonators for label-free biosensing. , 2013, Optics express.

[18]  S. Weiss,et al.  Guided mode biosensor based on grating coupled porous silicon waveguide. , 2011, Optics express.