The Anterior Cingulate and Error Avoidance

The precise role of the anterior cingulate cortex in monitoring, evaluating, and correcting behavior remains unclear despite numerous theories and much empirical data implicating it in cognitive control. The present event-related functional magnetic resonance imaging study was able to separate monitoring from error-specific functions by allowing subjects to reject a trial so as to avoid errors. Cingulate and left dorsolateral prefrontal activity was greatest on rejection trials but comparable for correct and error trials, whereas an error-specific response was observed in bilateral insula. A dissociation was also observed between the cingulate and the nucleus accumbens with the latter more active for error than reject trials. These results reveal that the functional role of the cingulate is not particular to errors but instead is related to an evaluative function concerned with on-line behavioral adjustment in the service of avoiding losses.

[1]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[2]  E. Donchin,et al.  Event-related brain potentials and error-related processing: an analysis of incorrect responses to go and no-go stimuli. , 1996, Psychophysiology.

[3]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[4]  Peter Dayan,et al.  A Neural Substrate of Prediction and Reward , 1997, Science.

[5]  M. Carrasco,et al.  The contribution of covert attention to the set-size and eccentricity effects in visual search. , 1998, Journal of experimental psychology. Human perception and performance.

[6]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[7]  T. Paus,et al.  Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies , 1998, Neuroreport.

[8]  S. Rauch,et al.  The counting stroop: An interference task specialized for functional neuroimaging—validation study with functional MRI , 1998, Human brain mapping.

[9]  E. Stein,et al.  Right hemispheric dominance of inhibitory control: an event-related functional MRI study. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[10]  A. Turken,et al.  Response selection in the human anterior cingulate cortex , 1999, Nature Neuroscience.

[11]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[12]  K. Kiehl,et al.  Error processing and the rostral anterior cingulate: an event-related fMRI study. , 2000, Psychophysiology.

[13]  R. Knight,et al.  Prefrontal–cingulate interactions in action monitoring , 2000, Nature Neuroscience.

[14]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[15]  H. Critchley,et al.  Neuroanatomical basis for first- and second-order representations of bodily states , 2001, Nature Neuroscience.

[16]  D. Kahneman,et al.  Functional Imaging of Neural Responses to Expectancy and Experience of Monetary Gains and Losses tasks with monetary payoffs , 2001 .

[17]  Brian Knutson,et al.  Dissociation of reward anticipation and outcome with event-related fMRI , 2001, Neuroreport.

[18]  Clay B. Holroyd,et al.  Why is there an ERN/Ne on correct trials? Response representations, stimulus-related components, and the theory of error-processing , 2001, Biological Psychology.

[19]  T. Paus.  Primate anterior cingulate cortex: Where motor control, drive and cognition interface , 2001, Nature Reviews Neuroscience.

[20]  W. Gehring,et al.  Functions of the Medial Frontal Cortex in the Processing of Conflict and Errors , 2001, The Journal of Neuroscience.

[21]  Bruce D. McCandliss,et al.  Testing the Efficiency and Independence of Attentional Networks , 2002, Journal of Cognitive Neuroscience.

[22]  Clay B. Holroyd,et al.  The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. , 2002, Psychological review.

[23]  H. Critchley,et al.  Fear Conditioning in Humans The Influence of Awareness and Autonomic Arousal on Functional Neuroanatomy , 2002, Neuron.

[24]  A. Turken,et al.  Dissociation between conflict detection and error monitoring in the human anterior cingulate cortex , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[25]  H. Garavan,et al.  Dissociable Executive Functions in the Dynamic Control of Behavior: Inhibition, Error Detection, and Correction , 2002, NeuroImage.

[26]  H Garavan,et al.  A midline dissociation between error-processing and response-conflict monitoring , 2003, NeuroImage.

[27]  Hugh Garavan,et al.  Individual differences in error processing: a review and reanalysis of three event-related fMRI studies using the GO/NOGO task. , 2004, Cerebral cortex.

[28]  H. Critchley.  The human cortex responds to an interoceptive challenge. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[29]  H. Critchley,et al.  Neural systems supporting interoceptive awareness , 2004, Nature Neuroscience.

[30]  Jonathan D. Cohen,et al.  Conflict monitoring and anterior cingulate cortex: an update , 2004, Trends in Cognitive Sciences.

[31]  Jonathan D. Cohen,et al.  Anterior Cingulate Conflict Monitoring and Adjustments in Control , 2004, Science.

[32]  D. Yves von Cramon,et al.  Neuroimaging of Performance Monitoring: Error Detection and Beyond , 2004, Cortex.

[33]  Julie C. Stout,et al.  Neurocognitive insights into substance abuse , 2005, Trends in Cognitive Sciences.

[34]  Joshua W. Brown,et al.  Learned Predictions of Error Likelihood in the Anterior Cingulate Cortex , 2005, Science.