Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models.

[1]  C. Lang,et al.  A randomized controlled trial of dapagliflozin on left ventricular hypertrophy in people with type two diabetes: the DAPA-LVH trial , 2020, European heart journal.

[2]  Weiqi Wang,et al.  Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction , 2020, Circulation research.

[3]  Shanshan Luo,et al.  A novel rhynchophylline analog, Y396, inhibits endothelial dysfunction induced by oxidative stress in diabetes through EGF receptor. , 2019, Antioxidants & redox signaling.

[4]  J. Shaw,et al.  Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. , 2019, Diabetes research and clinical practice.

[5]  T. Aitman,et al.  Camk2n1 Is a Negative Regulator of Blood Pressure, Left Ventricular Mass, Insulin Sensitivity, and Promotes Adiposity , 2019, Hypertension.

[6]  Xue Li,et al.  Gadofullerene Nanoparticles Reverse Dysfunctions of Pancreas and Improve Hepatic Insulin Resistance for Type 2 Diabetes Mellitus Treatment. , 2019, ACS nano.

[7]  Shanshan Liu,et al.  Pretreatment of ghrelin protects H9c2 cells against hypoxia/reoxygenation-induced cell death via PI3K/AKT and AMPK pathways , 2019, Artificial cells, nanomedicine, and biotechnology.

[8]  Xu Shen,et al.  Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice , 2019, Acta Pharmacologica Sinica.

[9]  Z. Younossi.  Non-alcoholic fatty liver disease - A global public health perspective. , 2019, Journal of hepatology.

[10]  M. Netea,et al.  Firing Up Glycolysis: BCG Vaccination Effects on Type 1 Diabetes Mellitus , 2018, Trends in Endocrinology & Metabolism.

[11]  Dan Liu,et al.  Nuciferine ameliorates hepatic steatosis in high‐fat diet/streptozocin‐induced diabetic mice through a PPARα/PPARγ coactivator‐1α pathway , 2018, British journal of pharmacology.

[12]  Xu Lin,et al.  Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet‐induced insulin‐resistant mice , 2018, Hepatology.

[13]  Chun Fang,et al.  Ubiquitin‐Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6 , 2018, Hepatology.

[14]  Nam Hoon Kim,et al.  Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha‐2‐HS‐glycoprotein , 2018, Journal of pineal research.

[15]  Lei Yang,et al.  C-Phycocyanin inhibits hepatic gluconeogenesis and increases glycogen synthesis via activating Akt and AMPK in insulin resistance hepatocytes. , 2018, Food & function.

[16]  Huijun Sun,et al.  Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway , 2017, Pharmacological research.

[17]  Justin Lee,et al.  PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism , 2017, Molecular metabolism.

[18]  Huadong Liu,et al.  Akt activation: A potential strategy to ameliorate insulin resistance. , 2017, Diabetes research and clinical practice.

[19]  D. Accili,et al.  Biochemical and cellular properties of insulin receptor signalling , 2017, Nature Reviews Molecular Cell Biology.

[20]  M. Birnbaum,et al.  Unraveling the Regulation of Hepatic Metabolism by Insulin , 2017, Trends in Endocrinology & Metabolism.

[21]  William J. Israelsen,et al.  Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction , 2017, Nature Medicine.

[22]  B. Geng,et al.  NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway , 2017, Diabetes.

[23]  S. Chakraborty,et al.  Hyperglycemia‐ and hyperinsulinemia‐induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[24]  Chang-An Geng,et al.  Chemical and biological comparison of different sections of Uncaria rhynchophylla (Gou-Teng) , 2017, European journal of mass spectrometry.

[25]  Wei Ying,et al.  Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance , 2016, Cell.

[26]  Hongbo Song,et al.  The potential beneficial effects of phenolic compounds isolated from A. pilosa Ledeb on insulin-resistant hepatic HepG2 cells. , 2016, Food & function.

[27]  G. Sweeney,et al.  Lipocalin-2 inhibits autophagy and induces insulin resistance in H9c2 cells , 2016, Molecular and Cellular Endocrinology.

[28]  Hongliang Li,et al.  Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling , 2016, Nature Communications.

[29]  M. Kohno,et al.  Targeting the ERK signaling pathway as a potential treatment for insulin resistance and type 2 diabetes. , 2016, American journal of physiology. Endocrinology and metabolism.

[30]  Wenbo Tang,et al.  Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation. , 2016, Antioxidants & redox signaling.

[31]  Hongbo Song,et al.  Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK , 2015 .

[32]  Hai-Jian Sun,et al.  Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes. , 2015, Clinical science.

[33]  J. Gautier,et al.  Metabolic roles of PGC-1α and its implications for type 2 diabetes. , 2015, Diabetes & metabolism.

[34]  Yi-Zhun Zhu,et al.  The Novel Analogue of Hirsutine as an Anti-Hypertension and Vasodilatary Agent Both In Vitro and In Vivo , 2015, PloS one.

[35]  S. Tangvarasittichai.  Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. , 2015, World journal of diabetes.

[36]  Stephan M. Winkler,et al.  Identification of novel insulin mimetic drugs by quantitative total internal reflection fluorescence (TIRF) microscopy , 2014, British journal of pharmacology.

[37]  W. Jia,et al.  Berberine Promotes Glucose Consumption Independently of AMP-Activated Protein Kinase Activation , 2014, PloS one.

[38]  Melissa M. Thomas,et al.  AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice , 2014, Diabetologia.

[39]  Jenny J. Yang,et al.  Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity , 2014, Diabetes.

[40]  R. Mackenzie,et al.  Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes , 2014, Diabetes, metabolic syndrome and obesity : targets and therapy.

[41]  Yuan Zhang,et al.  Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling , 2014, Diabetes.

[42]  M. White,et al.  Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance , 2013, Diabetes.

[43]  Jing Li,et al.  Berberine improves insulin resistance in cardiomyocytes via activation of 5'-adenosine monophosphate-activated protein kinase. , 2013, Metabolism: clinical and experimental.

[44]  Yi-Chun Zhu,et al.  Hydrogen sulfide treatment promotes glucose uptake by increasing insulin receptor sensitivity and ameliorates kidney lesions in type 2 diabetes. , 2013, Antioxidants & redox signaling.

[45]  Michalis D. Mantzaris,et al.  Insulin resistance: an adaptive mechanism becomes maladaptive in the current environment - an evolutionary perspective. , 2013, Metabolism: clinical and experimental.

[46]  G. Pan,et al.  A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies. , 2013, Fitoterapia.

[47]  F. Schütz,et al.  Hepatic glucose sensing is required to preserve β cell glucose competence. , 2013, The Journal of clinical investigation.

[48]  M. Gu,et al.  Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice , 2013, Diabetes.

[49]  Alan R. Saltiel,et al.  Regulation of glucose transport by insulin: traffic control of GLUT4 , 2012, Nature Reviews Molecular Cell Biology.

[50]  D. Hardie,et al.  AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.

[51]  Nan Jiang,et al.  Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. , 2012, The Journal of clinical investigation.

[52]  C. Deng,et al.  Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. , 2011, The Journal of clinical investigation.

[53]  Y. Zhu,et al.  Protective effects of novel single compound, Hirsutine on hypoxic neonatal rat cardiomyocytes. , 2011, European journal of pharmacology.

[54]  Gaochao Zhou,et al.  AMPK: an emerging drug target for diabetes and the metabolic syndrome. , 2009, Cell metabolism.

[55]  H. Tilg,et al.  Insulin resistance, inflammation, and non-alcoholic fatty liver disease , 2008, Trends in Endocrinology & Metabolism.

[56]  B. Kemp,et al.  AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5 , 2008, Diabetes.

[57]  B. Morio,et al.  Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. , 2008, The Journal of clinical investigation.

[58]  Q. Zhai,et al.  SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. , 2007, Cell metabolism.

[59]  B. Spiegelman,et al.  AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.

[60]  R. Heine,et al.  Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats , 2005, Diabetologia.

[61]  B. Ahrén,et al.  The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. , 2004, Diabetes.

[62]  A. Butte,et al.  Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[63]  F. Leonetti,et al.  Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity. , 2003, Obesity research.

[64]  B. Thorens,et al.  Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. , 2002, American journal of physiology. Endocrinology and metabolism.

[65]  H. Spitznagel,et al.  Substrate Metabolism, Hormone Interaction, and Angiotensin-Converting Enzyme Inhibitors in Left Ventricular Hypertrophy , 1996, Diabetes.

[66]  R. Govers.  Cellular regulation of glucose uptake by glucose transporter GLUT4. , 2014, Advances in Clinical Chemistry.

[67]  Jianping Ye,et al.  Berberine improves glucose metabolism through induction of glycolysis. , 2008, American journal of physiology. Endocrinology and metabolism.

[68]  Wen De-hui.  Effects of Ramulus Uncariae et Uncus on High-fat-fed Obese Rats , 2006 .

[69]  Xiaohui Xie,et al.  Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. , 2004, Proceedings of the National Academy of Sciences of the United States of America.