Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae

ABSTRACT In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.

[1]  J. Guarro,et al.  Efficacy of Voriconazole in Treatment of Systemic Scedosporiosis in Neutropenic Mice , 2003, Antimicrobial Agents and Chemotherapy.

[2]  V. Rickerts,et al.  Successful treatment of disseminated mucormycosis with a combination of liposomal amphotericin B and posaconazole in a patient with acute myeloid leukaemia , 2006, Mycoses.

[3]  Clinical,et al.  Reference method for broth dilution antifungal susceptibility testing of filamentous fungi : Approved standard , 2008 .

[4]  V. Lorian.  Antibiotics in laboratory medicine , 2005 .

[5]  J. Graybill,et al.  In Vitro Activities of Posaconazole, Itraconazole, Voriconazole, Amphotericin B, and Fluconazole against 37 Clinical Isolates of Zygomycetes , 2002, Antimicrobial Agents and Chemotherapy.

[6]  E. Bruck,et al.  National Committee for Clinical Laboratory Standards. , 1980, Pediatrics.

[7]  M. Rinaldi,et al.  In Vitro Susceptibilities of 217 Clinical Isolates of Zygomycetes to Conventional and New Antifungal Agents , 2007, Antimicrobial Agents and Chemotherapy.

[8]  D. Kontoyiannis,et al.  Epidemiology and outcome of zygomycosis: a review of 929 reported cases. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  Thomas R Rogers,et al.  Treatment of zygomycosis: current and new options. , 2008, The Journal of antimicrobial chemotherapy.

[10]  A. Santinelli,et al.  Posaconazole Prophylaxis in Experimental Systemic Zygomycosis , 2006, Antimicrobial Agents and Chemotherapy.

[11]  Brad Spellberg,et al.  Novel Perspectives on Mucormycosis: Pathophysiology, Presentation, and Management , 2005, Clinical Microbiology Reviews.

[12]  J. Meis,et al.  Activity of Posaconazole in Treatment of Experimental Disseminated Zygomycosis , 2003, Antimicrobial Agents and Chemotherapy.

[13]  J. Ruiloba.  [Antimicrobial combinations]. , 1972, Gaceta medica de Mexico.

[14]  D. Kontoyiannis,et al.  Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[15]  V. Lorian.  Antibiotics in laboratory medicine. 3rd edition. , 1991 .

[16]  J. Perfect,et al.  Combination Antifungal Therapy , 2004, Antimicrobial Agents and Chemotherapy.

[17]  A. Sugar,et al.  Combination Antifungal Therapy in Treatment of Murine Pulmonary Mucormycosis: Roles of Quinolones and Azoles , 2000, Antimicrobial Agents and Chemotherapy.

[18]  M. Schuster,et al.  Posaconazole as Salvage Therapy for Zygomycosis , 2006, Antimicrobial Agents and Chemotherapy.